Omega-3 fatty acids from fish oils and cardiovascular disease
Fish and fish oils contain the omega-3 fatty acids known as eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA). Epidemiological studies have shown an inverse relation between the dietary consumption of fish containing EPA/DHA and mortality from coronary heart disease. These relationships ha...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2004-08, Vol.263 (1-2), p.217-225 |
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| description | Fish and fish oils contain the omega-3 fatty acids known as eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA). Epidemiological studies have shown an inverse relation between the dietary consumption of fish containing EPA/DHA and mortality from coronary heart disease. These relationships have been substantiated from blood measures of omega-3 fatty acids including DHA as a physiological biomarker for omega-3 fatty acid status. Controlled intervention trials with fish oil supplements enriched in EPA/DHA have shown their potential to reduce mortality in post-myocardial infarction patients with a substantial reduction in the risk of sudden cardiac death. The cardioprotective effects of EPA/DHA are widespread, appear to act independently of blood cholesterol reduction, and are mediated by diverse mechanisms. Their overall effects include anti-arrhythmic, blood triglyceride-lowering, anti-thrombotic, anti-inflammatory, endothelial relaxation, plus others. Current dietary intakes of EPA/DHA in North America and elsewhere are well below those recommended by the American Heart Association for the management of patients with coronary heart disease. |
| doi_str_mv | 10.1023/B:MCBI.0000041863.11248.8d |
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Epidemiological studies have shown an inverse relation between the dietary consumption of fish containing EPA/DHA and mortality from coronary heart disease. These relationships have been substantiated from blood measures of omega-3 fatty acids including DHA as a physiological biomarker for omega-3 fatty acid status. Controlled intervention trials with fish oil supplements enriched in EPA/DHA have shown their potential to reduce mortality in post-myocardial infarction patients with a substantial reduction in the risk of sudden cardiac death. The cardioprotective effects of EPA/DHA are widespread, appear to act independently of blood cholesterol reduction, and are mediated by diverse mechanisms. Their overall effects include anti-arrhythmic, blood triglyceride-lowering, anti-thrombotic, anti-inflammatory, endothelial relaxation, plus others. 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Epidemiological studies have shown an inverse relation between the dietary consumption of fish containing EPA/DHA and mortality from coronary heart disease. These relationships have been substantiated from blood measures of omega-3 fatty acids including DHA as a physiological biomarker for omega-3 fatty acid status. Controlled intervention trials with fish oil supplements enriched in EPA/DHA have shown their potential to reduce mortality in post-myocardial infarction patients with a substantial reduction in the risk of sudden cardiac death. The cardioprotective effects of EPA/DHA are widespread, appear to act independently of blood cholesterol reduction, and are mediated by diverse mechanisms. Their overall effects include anti-arrhythmic, blood triglyceride-lowering, anti-thrombotic, anti-inflammatory, endothelial relaxation, plus others. Current dietary intakes of EPA/DHA in North America and elsewhere are well below those recommended by the American Heart Association for the management of patients with coronary heart disease.</description><subject>Blood</subject><subject>Cardiotonic Agents - administration & dosage</subject><subject>Cardiotonic Agents - chemistry</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - diet therapy</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Clinical Trials as Topic</subject><subject>Diet</subject><subject>Fatty acids</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fatty Acids, Omega-3 - blood</subject><subject>Fatty Acids, Omega-3 - chemistry</subject><subject>Fish</subject><subject>Fish oils</subject><subject>Fish Oils - administration & dosage</subject><subject>Fish Oils - chemistry</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Mental Disorders - 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Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holub, Darren J</au><au>Holub, Bruce J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Omega-3 fatty acids from fish oils and cardiovascular disease</atitle><jtitle>Molecular and cellular biochemistry</jtitle><addtitle>Mol Cell Biochem</addtitle><date>2004-08</date><risdate>2004</risdate><volume>263</volume><issue>1-2</issue><spage>217</spage><epage>225</epage><pages>217-225</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Fish and fish oils contain the omega-3 fatty acids known as eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA). Epidemiological studies have shown an inverse relation between the dietary consumption of fish containing EPA/DHA and mortality from coronary heart disease. These relationships have been substantiated from blood measures of omega-3 fatty acids including DHA as a physiological biomarker for omega-3 fatty acid status. Controlled intervention trials with fish oil supplements enriched in EPA/DHA have shown their potential to reduce mortality in post-myocardial infarction patients with a substantial reduction in the risk of sudden cardiac death. The cardioprotective effects of EPA/DHA are widespread, appear to act independently of blood cholesterol reduction, and are mediated by diverse mechanisms. Their overall effects include anti-arrhythmic, blood triglyceride-lowering, anti-thrombotic, anti-inflammatory, endothelial relaxation, plus others. Current dietary intakes of EPA/DHA in North America and elsewhere are well below those recommended by the American Heart Association for the management of patients with coronary heart disease.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>15524182</pmid><doi>10.1023/B:MCBI.0000041863.11248.8d</doi><tpages>9</tpages></addata></record> |
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| ispartof | Molecular and cellular biochemistry, 2004-08, Vol.263 (1-2), p.217-225 |
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| subjects | Blood Cardiotonic Agents - administration & dosage Cardiotonic Agents - chemistry Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - diet therapy Cardiovascular Diseases - epidemiology Cardiovascular Diseases - prevention & control Clinical Trials as Topic Diet Fatty acids Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - blood Fatty Acids, Omega-3 - chemistry Fish Fish oils Fish Oils - administration & dosage Fish Oils - chemistry Heart attacks Humans Mental Disorders - blood Mental Disorders - diet therapy Mental Disorders - etiology Molecular Structure Mortality Myocardial infarction Nutrition Risk Factors |
| title | Omega-3 fatty acids from fish oils and cardiovascular disease |
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