Phospholipases A

Phospholipase A(1) (PLA(1)) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA(1) enzymes. Where their function is known, PLA(1)s have been show...

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Veröffentlicht in:	International journal of molecular sciences 2011-01, Vol.12 (1), p.588-612
Hauptverfasser:	Richmond, Gregory S, Smith, Terry K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Lysophospholipids - metabolism Phospholipases A - metabolism Phospholipases A1 - metabolism Substrate Specificity Type C Phospholipases - metabolism
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creator	Richmond, Gregory S Smith, Terry K
description	Phospholipase A(1) (PLA(1)) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA(1) enzymes. Where their function is known, PLA(1)s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.
doi_str_mv	10.3390/ijms12010588
format	Article
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source	MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; PMC (PubMed Central); EZB-FREE-00999 freely available EZB journals
subjects	Animals Humans Lysophospholipids - metabolism Phospholipases A - metabolism Phospholipases A1 - metabolism Substrate Specificity Type C Phospholipases - metabolism
title	Phospholipases A
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