Glucocorticoids for the treatment of anaphylaxis: Cochrane systematic review
To cite this article: Choo KJL, Simons E, Sheikh A. Glucocorticoids for the treatment of anaphylaxis: Cochrane systematic review. Allergy 2010; 65: 1205-1211. Anaphylaxis is a serious hypersensitivity reaction that is rapid in onset and may result in death. A number of guidelines recommend glucocort...
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| Veröffentlicht in: | Allergy (Copenhagen) 2010-10, Vol.65 (10), p.1205-1211 |
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| description | To cite this article: Choo KJL, Simons E, Sheikh A. Glucocorticoids for the treatment of anaphylaxis: Cochrane systematic review. Allergy 2010; 65: 1205-1211. Anaphylaxis is a serious hypersensitivity reaction that is rapid in onset and may result in death. A number of guidelines recommend glucocorticoids for the treatment of people experiencing anaphylaxis. We sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, Issue 3), MEDLINE (Ovid) (1966 to September 2009), EMBASE (Ovid) (1988 to September 2009), CINAHL (EBSCOhost) (to September 2009) and The Science Citation Index Expanded (SCI-EXPANDED) (1945 to September 2009). We also searched the UK National Research Register and websites listing ongoing trials and contacted international experts in anaphylaxis in an attempt to locate unpublished material. We sought to include randomized and quasi-randomized controlled trials comparing glucocorticoids with any control (either placebo, adrenaline (epinephrine), an antihistamine, or any combination of these). Two authors independently assessed articles for inclusion. None of the 2496 reports identified satisfied the inclusion criteria. We conclude that there is no evidence from high-quality studies for the use of steroids in the emergency management of anaphylaxis. Therefore, we can neither support nor refute the use of these drugs for this purpose. |
| doi_str_mv | 10.1111/j.1398-9995.2010.02424.x |
| format | Article |
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Glucocorticoids for the treatment of anaphylaxis: Cochrane systematic review. Allergy 2010; 65: 1205-1211. Anaphylaxis is a serious hypersensitivity reaction that is rapid in onset and may result in death. A number of guidelines recommend glucocorticoids for the treatment of people experiencing anaphylaxis. We sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, Issue 3), MEDLINE (Ovid) (1966 to September 2009), EMBASE (Ovid) (1988 to September 2009), CINAHL (EBSCOhost) (to September 2009) and The Science Citation Index Expanded (SCI-EXPANDED) (1945 to September 2009). We also searched the UK National Research Register and websites listing ongoing trials and contacted international experts in anaphylaxis in an attempt to locate unpublished material. We sought to include randomized and quasi-randomized controlled trials comparing glucocorticoids with any control (either placebo, adrenaline (epinephrine), an antihistamine, or any combination of these). Two authors independently assessed articles for inclusion. None of the 2496 reports identified satisfied the inclusion criteria. We conclude that there is no evidence from high-quality studies for the use of steroids in the emergency management of anaphylaxis. Therefore, we can neither support nor refute the use of these drugs for this purpose.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/j.1398-9995.2010.02424.x</identifier><identifier>PMID: 20584003</identifier><identifier>CODEN: LLRGDY</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Allergies ; Anaphylaxis ; Anaphylaxis - complications ; Anaphylaxis - drug therapy ; Antihistamines ; Biological and medical sciences ; cochrane ; Controlled Clinical Trials as Topic ; Dermatology ; Drug Evaluation ; Drug therapy ; Drugs ; effectiveness ; Epinephrine ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Glucocorticoids ; Glucocorticoids - adverse effects ; Glucocorticoids - therapeutic use ; Humans ; Hypersensitivity ; Medical sciences ; Registries ; Reviews ; Risk Assessment ; Sarcoidosis. 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Glucocorticoids for the treatment of anaphylaxis: Cochrane systematic review. Allergy 2010; 65: 1205-1211. Anaphylaxis is a serious hypersensitivity reaction that is rapid in onset and may result in death. A number of guidelines recommend glucocorticoids for the treatment of people experiencing anaphylaxis. We sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, Issue 3), MEDLINE (Ovid) (1966 to September 2009), EMBASE (Ovid) (1988 to September 2009), CINAHL (EBSCOhost) (to September 2009) and The Science Citation Index Expanded (SCI-EXPANDED) (1945 to September 2009). We also searched the UK National Research Register and websites listing ongoing trials and contacted international experts in anaphylaxis in an attempt to locate unpublished material. We sought to include randomized and quasi-randomized controlled trials comparing glucocorticoids with any control (either placebo, adrenaline (epinephrine), an antihistamine, or any combination of these). Two authors independently assessed articles for inclusion. None of the 2496 reports identified satisfied the inclusion criteria. We conclude that there is no evidence from high-quality studies for the use of steroids in the emergency management of anaphylaxis. Therefore, we can neither support nor refute the use of these drugs for this purpose.</description><subject>Allergies</subject><subject>Anaphylaxis</subject><subject>Anaphylaxis - complications</subject><subject>Anaphylaxis - drug therapy</subject><subject>Antihistamines</subject><subject>Biological and medical sciences</subject><subject>cochrane</subject><subject>Controlled Clinical Trials as Topic</subject><subject>Dermatology</subject><subject>Drug Evaluation</subject><subject>Drug therapy</subject><subject>Drugs</subject><subject>effectiveness</subject><subject>Epinephrine</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Glucocorticoids</subject><subject>Glucocorticoids - adverse effects</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Medical sciences</subject><subject>Registries</subject><subject>Reviews</subject><subject>Risk Assessment</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Steroid hormones</subject><subject>Steroids</subject><subject>Systematic review</subject><subject>United Kingdom</subject><subject>United States</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1r2zAUhsXYaNNuf2ETg9ErZ_q0rEEvSujHwLCLttdCkY8WBzvKJHtN_v3kJu1gV9ONhc_zHr08CGFK5jSfr-s55boqtNZyzkj-S5hgYr57g2avg7dolieyEJJXp-gspTUhRDFNTtApI7IShPAZqm-70QUX4tC60DYJ-xDxsAI8RLBDD5sBB4_txm5X-87u2vQNL4JbRbsBnPZpgN7mJI7wu4Wn9-idt12CD8fvOXq8uX5Y3BX1j9vvi6u6cFIrUQBnTS6srWeV9sJqWzZL6sDrRjidJ65kSnjOGLVCgQZgy6YpiQQqfbmU_BxdHPZuY_g1QhpM3yYHXZdbhTGZSnKhKFEqk5__IddhjJtcziipNWOlmKDqALkYUorgzTa2vY17Q4mZfJu1mbSaSauZfJtn32aXox-P-8dlD81r8EVwBr4cAZuc7XwW59r0l-NMVlVJMnd54J7aDvb_XcBc1fV0y_lPh7y3wdifMb_xeJ9JTmjez5jifwAXK6Rv</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Choo, K.J.L</creator><creator>Simons, E</creator><creator>Sheikh, A</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>201010</creationdate><title>Glucocorticoids for the treatment of anaphylaxis: Cochrane systematic review</title><author>Choo, K.J.L ; Simons, E ; Sheikh, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5974-e32d0249af289f4a9a6db1cef9d4c9024c6274f3221a47e9ee2bdd605e15f6b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Allergies</topic><topic>Anaphylaxis</topic><topic>Anaphylaxis - complications</topic><topic>Anaphylaxis - drug therapy</topic><topic>Antihistamines</topic><topic>Biological and medical sciences</topic><topic>cochrane</topic><topic>Controlled Clinical Trials as Topic</topic><topic>Dermatology</topic><topic>Drug Evaluation</topic><topic>Drug therapy</topic><topic>Drugs</topic><topic>effectiveness</topic><topic>Epinephrine</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Glucocorticoids</topic><topic>Glucocorticoids - adverse effects</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Medical sciences</topic><topic>Registries</topic><topic>Reviews</topic><topic>Risk Assessment</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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Glucocorticoids for the treatment of anaphylaxis: Cochrane systematic review. Allergy 2010; 65: 1205-1211. Anaphylaxis is a serious hypersensitivity reaction that is rapid in onset and may result in death. A number of guidelines recommend glucocorticoids for the treatment of people experiencing anaphylaxis. We sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, Issue 3), MEDLINE (Ovid) (1966 to September 2009), EMBASE (Ovid) (1988 to September 2009), CINAHL (EBSCOhost) (to September 2009) and The Science Citation Index Expanded (SCI-EXPANDED) (1945 to September 2009). We also searched the UK National Research Register and websites listing ongoing trials and contacted international experts in anaphylaxis in an attempt to locate unpublished material. We sought to include randomized and quasi-randomized controlled trials comparing glucocorticoids with any control (either placebo, adrenaline (epinephrine), an antihistamine, or any combination of these). Two authors independently assessed articles for inclusion. None of the 2496 reports identified satisfied the inclusion criteria. We conclude that there is no evidence from high-quality studies for the use of steroids in the emergency management of anaphylaxis. Therefore, we can neither support nor refute the use of these drugs for this purpose.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>20584003</pmid><doi>10.1111/j.1398-9995.2010.02424.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Allergies Anaphylaxis Anaphylaxis - complications Anaphylaxis - drug therapy Antihistamines Biological and medical sciences cochrane Controlled Clinical Trials as Topic Dermatology Drug Evaluation Drug therapy Drugs effectiveness Epinephrine Fundamental and applied biological sciences. Psychology Fundamental immunology Glucocorticoids Glucocorticoids - adverse effects Glucocorticoids - therapeutic use Humans Hypersensitivity Medical sciences Registries Reviews Risk Assessment Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Steroid hormones Steroids Systematic review United Kingdom United States |
| title | Glucocorticoids for the treatment of anaphylaxis: Cochrane systematic review |
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