Geographical variations in the prevalence of atopic sensitization in six study sites across Canada

To cite this article: Chan‐Yeung M, Anthonisen NR, Becklake MR, Bowie D, Sonia Buist A, Dimich‐Ward H, Ernst P, Sears MR, Siersted HC, Sweet L, Van Til L, Manfreda J. Geographical variations in the prevalence of atopic sensitization in six study sites across Canada. Allergy 2010; 65: 1404–1413. Back...

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Veröffentlicht in:Allergy (Copenhagen) 2010-11, Vol.65 (11), p.1404-1413
Hauptverfasser: Chan‐Yeung, M., Anthonisen, N. R., Becklake, M. R., Bowie, D., Sonia Buist, A., Dimich‐Ward, H., Ernst, P., Sears, M. R., Siersted, H. C., Sweet, L., Van Til, L., Manfreda, J.
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container_end_page 1413
container_issue 11
container_start_page 1404
container_title Allergy (Copenhagen)
container_volume 65
creator Chan‐Yeung, M.
Anthonisen, N. R.
Becklake, M. R.
Bowie, D.
Sonia Buist, A.
Dimich‐Ward, H.
Ernst, P.
Sears, M. R.
Siersted, H. C.
Sweet, L.
Van Til, L.
Manfreda, J.
description To cite this article: Chan‐Yeung M, Anthonisen NR, Becklake MR, Bowie D, Sonia Buist A, Dimich‐Ward H, Ernst P, Sears MR, Siersted HC, Sweet L, Van Til L, Manfreda J. Geographical variations in the prevalence of atopic sensitization in six study sites across Canada. Allergy 2010; 65: 1404–1413. Background:  Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey‐1 (ECRHS‐1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to compare the results with some ECRHS‐1 centers. Methods:  Adults aged 20–44 years in six study sites across Canada underwent allergy skin testing using 14 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) cat, cockroach, grasses (Timothy grass, Kentucky grass), molds (Cladosporium herbarium, Alternaria alternata, Aspergillus fumigatus, Penicillium), trees (tree mix, birch, Olea europea), and common ragweed. Results:  The overall prevalence of atopy (skin test over 0 mm to any allergen) was 62.7%. There was significant geographical variation in the prevalence of atopy in the six study sites (lowest 55.6% [95% C.I.51.3–59.9] in Prince Edward Island, highest 66.0 [61.7–70.3] in Montreal) and of sensitization to each of the allergens tested even after adjustment for confounders. When the first eight of the nine allergens in the ECRHS were used to estimate the prevalence of atopic sensitization, the prevalence of atopy in Canada was 57% compared with 35.2% overall for centers in the ECRHS. The prevalence of atopy in Vancouver (57% [52.3–61.8]) was close to that of Portland, Oregon (52.1% [46.2–58.0]). Conclusion:  There was a significant variation in atopic sensitization among different study sites across Canada. The prevalence of atopic sensitization is relatively high in Canada compared with sites in the ECRHS and this may, in part, account for the high prevalence of asthma and asthma symptoms in Canada.
doi_str_mv 10.1111/j.1398-9995.2010.02399.x
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R. ; Becklake, M. R. ; Bowie, D. ; Sonia Buist, A. ; Dimich‐Ward, H. ; Ernst, P. ; Sears, M. R. ; Siersted, H. C. ; Sweet, L. ; Van Til, L. ; Manfreda, J.</creator><creatorcontrib>Chan‐Yeung, M. ; Anthonisen, N. R. ; Becklake, M. R. ; Bowie, D. ; Sonia Buist, A. ; Dimich‐Ward, H. ; Ernst, P. ; Sears, M. R. ; Siersted, H. C. ; Sweet, L. ; Van Til, L. ; Manfreda, J.</creatorcontrib><description>To cite this article: Chan‐Yeung M, Anthonisen NR, Becklake MR, Bowie D, Sonia Buist A, Dimich‐Ward H, Ernst P, Sears MR, Siersted HC, Sweet L, Van Til L, Manfreda J. Geographical variations in the prevalence of atopic sensitization in six study sites across Canada. Allergy 2010; 65: 1404–1413. Background:  Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey‐1 (ECRHS‐1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to compare the results with some ECRHS‐1 centers. Methods:  Adults aged 20–44 years in six study sites across Canada underwent allergy skin testing using 14 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) cat, cockroach, grasses (Timothy grass, Kentucky grass), molds (Cladosporium herbarium, Alternaria alternata, Aspergillus fumigatus, Penicillium), trees (tree mix, birch, Olea europea), and common ragweed. Results:  The overall prevalence of atopy (skin test over 0 mm to any allergen) was 62.7%. There was significant geographical variation in the prevalence of atopy in the six study sites (lowest 55.6% [95% C.I.51.3–59.9] in Prince Edward Island, highest 66.0 [61.7–70.3] in Montreal) and of sensitization to each of the allergens tested even after adjustment for confounders. When the first eight of the nine allergens in the ECRHS were used to estimate the prevalence of atopic sensitization, the prevalence of atopy in Canada was 57% compared with 35.2% overall for centers in the ECRHS. The prevalence of atopy in Vancouver (57% [52.3–61.8]) was close to that of Portland, Oregon (52.1% [46.2–58.0]). Conclusion:  There was a significant variation in atopic sensitization among different study sites across Canada. The prevalence of atopic sensitization is relatively high in Canada compared with sites in the ECRHS and this may, in part, account for the high prevalence of asthma and asthma symptoms in Canada.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/j.1398-9995.2010.02399.x</identifier><identifier>PMID: 20557300</identifier><identifier>CODEN: LLRGDY</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Age Distribution ; Allergens ; Allergies ; Alternaria alternata ; Animals ; Aspergillus fumigatus ; Asthma ; Asthma - epidemiology ; Atopy ; Biological and medical sciences ; Canada ; Canada - epidemiology ; Cladosporium ; Dermatology ; Dermatophagoides farinae ; Dermatophagoides pteronyssinus ; Diagnostic tests ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Geographical variations ; Grasses ; Humans ; Hypersensitivity ; Hypersensitivity, Immediate - epidemiology ; Islands ; Male ; Medical sciences ; Molds ; Olea europaea ; Penicillium ; Prevalence ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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R.</creatorcontrib><creatorcontrib>Becklake, M. R.</creatorcontrib><creatorcontrib>Bowie, D.</creatorcontrib><creatorcontrib>Sonia Buist, A.</creatorcontrib><creatorcontrib>Dimich‐Ward, H.</creatorcontrib><creatorcontrib>Ernst, P.</creatorcontrib><creatorcontrib>Sears, M. R.</creatorcontrib><creatorcontrib>Siersted, H. C.</creatorcontrib><creatorcontrib>Sweet, L.</creatorcontrib><creatorcontrib>Van Til, L.</creatorcontrib><creatorcontrib>Manfreda, J.</creatorcontrib><title>Geographical variations in the prevalence of atopic sensitization in six study sites across Canada</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>To cite this article: Chan‐Yeung M, Anthonisen NR, Becklake MR, Bowie D, Sonia Buist A, Dimich‐Ward H, Ernst P, Sears MR, Siersted HC, Sweet L, Van Til L, Manfreda J. Geographical variations in the prevalence of atopic sensitization in six study sites across Canada. Allergy 2010; 65: 1404–1413. Background:  Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey‐1 (ECRHS‐1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to compare the results with some ECRHS‐1 centers. Methods:  Adults aged 20–44 years in six study sites across Canada underwent allergy skin testing using 14 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) cat, cockroach, grasses (Timothy grass, Kentucky grass), molds (Cladosporium herbarium, Alternaria alternata, Aspergillus fumigatus, Penicillium), trees (tree mix, birch, Olea europea), and common ragweed. Results:  The overall prevalence of atopy (skin test over 0 mm to any allergen) was 62.7%. There was significant geographical variation in the prevalence of atopy in the six study sites (lowest 55.6% [95% C.I.51.3–59.9] in Prince Edward Island, highest 66.0 [61.7–70.3] in Montreal) and of sensitization to each of the allergens tested even after adjustment for confounders. When the first eight of the nine allergens in the ECRHS were used to estimate the prevalence of atopic sensitization, the prevalence of atopy in Canada was 57% compared with 35.2% overall for centers in the ECRHS. The prevalence of atopy in Vancouver (57% [52.3–61.8]) was close to that of Portland, Oregon (52.1% [46.2–58.0]). Conclusion:  There was a significant variation in atopic sensitization among different study sites across Canada. The prevalence of atopic sensitization is relatively high in Canada compared with sites in the ECRHS and this may, in part, account for the high prevalence of asthma and asthma symptoms in Canada.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Allergens</subject><subject>Allergies</subject><subject>Alternaria alternata</subject><subject>Animals</subject><subject>Aspergillus fumigatus</subject><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Atopy</subject><subject>Biological and medical sciences</subject><subject>Canada</subject><subject>Canada - epidemiology</subject><subject>Cladosporium</subject><subject>Dermatology</subject><subject>Dermatophagoides farinae</subject><subject>Dermatophagoides pteronyssinus</subject><subject>Diagnostic tests</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Geographical variations</subject><subject>Grasses</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Hypersensitivity, Immediate - epidemiology</subject><subject>Islands</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molds</subject><subject>Olea europaea</subject><subject>Penicillium</subject><subject>Prevalence</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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R.</creator><creator>Becklake, M. R.</creator><creator>Bowie, D.</creator><creator>Sonia Buist, A.</creator><creator>Dimich‐Ward, H.</creator><creator>Ernst, P.</creator><creator>Sears, M. R.</creator><creator>Siersted, H. C.</creator><creator>Sweet, L.</creator><creator>Van Til, L.</creator><creator>Manfreda, J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7SS</scope></search><sort><creationdate>201011</creationdate><title>Geographical variations in the prevalence of atopic sensitization in six study sites across Canada</title><author>Chan‐Yeung, M. ; Anthonisen, N. R. ; Becklake, M. R. ; Bowie, D. ; Sonia Buist, A. ; Dimich‐Ward, H. ; Ernst, P. ; Sears, M. R. ; Siersted, H. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Geographical variations</topic><topic>Grasses</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Hypersensitivity, Immediate - epidemiology</topic><topic>Islands</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molds</topic><topic>Olea europaea</topic><topic>Penicillium</topic><topic>Prevalence</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Skin</topic><topic>Skin Tests</topic><topic>Surveys and Questionnaires</topic><topic>Sweet taste</topic><topic>Trees</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan‐Yeung, M.</creatorcontrib><creatorcontrib>Anthonisen, N. R.</creatorcontrib><creatorcontrib>Becklake, M. 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R.</au><au>Bowie, D.</au><au>Sonia Buist, A.</au><au>Dimich‐Ward, H.</au><au>Ernst, P.</au><au>Sears, M. R.</au><au>Siersted, H. C.</au><au>Sweet, L.</au><au>Van Til, L.</au><au>Manfreda, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Geographical variations in the prevalence of atopic sensitization in six study sites across Canada</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2010-11</date><risdate>2010</risdate><volume>65</volume><issue>11</issue><spage>1404</spage><epage>1413</epage><pages>1404-1413</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><coden>LLRGDY</coden><abstract>To cite this article: Chan‐Yeung M, Anthonisen NR, Becklake MR, Bowie D, Sonia Buist A, Dimich‐Ward H, Ernst P, Sears MR, Siersted HC, Sweet L, Van Til L, Manfreda J. Geographical variations in the prevalence of atopic sensitization in six study sites across Canada. Allergy 2010; 65: 1404–1413. Background:  Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey‐1 (ECRHS‐1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to compare the results with some ECRHS‐1 centers. Methods:  Adults aged 20–44 years in six study sites across Canada underwent allergy skin testing using 14 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) cat, cockroach, grasses (Timothy grass, Kentucky grass), molds (Cladosporium herbarium, Alternaria alternata, Aspergillus fumigatus, Penicillium), trees (tree mix, birch, Olea europea), and common ragweed. Results:  The overall prevalence of atopy (skin test over 0 mm to any allergen) was 62.7%. There was significant geographical variation in the prevalence of atopy in the six study sites (lowest 55.6% [95% C.I.51.3–59.9] in Prince Edward Island, highest 66.0 [61.7–70.3] in Montreal) and of sensitization to each of the allergens tested even after adjustment for confounders. When the first eight of the nine allergens in the ECRHS were used to estimate the prevalence of atopic sensitization, the prevalence of atopy in Canada was 57% compared with 35.2% overall for centers in the ECRHS. The prevalence of atopy in Vancouver (57% [52.3–61.8]) was close to that of Portland, Oregon (52.1% [46.2–58.0]). Conclusion:  There was a significant variation in atopic sensitization among different study sites across Canada. The prevalence of atopic sensitization is relatively high in Canada compared with sites in the ECRHS and this may, in part, account for the high prevalence of asthma and asthma symptoms in Canada.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20557300</pmid><doi>10.1111/j.1398-9995.2010.02399.x</doi><tpages>10</tpages></addata></record>
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subjects Adult
Age Distribution
Allergens
Allergies
Alternaria alternata
Animals
Aspergillus fumigatus
Asthma
Asthma - epidemiology
Atopy
Biological and medical sciences
Canada
Canada - epidemiology
Cladosporium
Dermatology
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Diagnostic tests
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Geographical variations
Grasses
Humans
Hypersensitivity
Hypersensitivity, Immediate - epidemiology
Islands
Male
Medical sciences
Molds
Olea europaea
Penicillium
Prevalence
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Skin
Skin Tests
Surveys and Questionnaires
Sweet taste
Trees
Young Adult
title Geographical variations in the prevalence of atopic sensitization in six study sites across Canada
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