Outcomes of cardiac surgery in trisomy 18 patients
The objective was to clarify the outcomes of cardiac surgery in trisomy 18 patients. We analysed 34 consecutive trisomy 18 patients, of whom 21 were males, with cardiac complications. They were divided into patients who underwent cardiac surgery and those who were conservatively treated. We compared...
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| Veröffentlicht in: | Cardiology in the young 2011-04, Vol.21 (2), p.209-215 |
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| container_title | Cardiology in the young |
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| creator | Muneuchi, Jun Yamamoto, Junko Takahashi, Yasuhiko Watanabe, Mamie Yuge, Tetsuji Ohno, Takuro Imoto, Yutaka Sese, Akira Joo, Kunitaka |
| description | The objective was to clarify the outcomes of cardiac surgery in trisomy 18 patients.
We analysed 34 consecutive trisomy 18 patients, of whom 21 were males, with cardiac complications. They were divided into patients who underwent cardiac surgery and those who were conservatively treated. We compared rates of survival and discharge alive between two groups.
The surgery group included nine patients, with six males, who underwent cardiac surgery - intracardiac repair in three patients, pulmonary arterial banding in five patients, and ligation of the ductus in one patient - at median age of 2.2 months, ranging from 0.5 to 9.8, and with median weight of 2.6 kilograms, ranging from 1.5 to 3.2. Cardiac surgery and pre-operative assisted ventilation were hazardous factors leading to death. In the surgery group, cumulative survival rates at 1 month, 6 months, 12 months, and 24 months were 63%, 38%, 25%, and 22%, respectively, compared with 51%, 26%, 9%, and 9% in the conservative group. There was a significant difference (p = 0.002). The cumulative rates of discharge alive at 1 month, 3 months, and 6 months were 0%, 12%, and 65% in the surgery group, which did not differ from the conservative group (p = 0.80).
Cardiac surgery contributed to increased survival rate but not the rate of discharge alive in trisomy 18 patients. Cardiac surgery could not prevent all the trisomy 18 patients from death. The indication of cardiac surgery should be carefully individualised to improve the quality of life in trisomy 18 patients and concerned surrounding people. |
| doi_str_mv | 10.1017/S1047951110001848 |
| format | Article |
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We analysed 34 consecutive trisomy 18 patients, of whom 21 were males, with cardiac complications. They were divided into patients who underwent cardiac surgery and those who were conservatively treated. We compared rates of survival and discharge alive between two groups.
The surgery group included nine patients, with six males, who underwent cardiac surgery - intracardiac repair in three patients, pulmonary arterial banding in five patients, and ligation of the ductus in one patient - at median age of 2.2 months, ranging from 0.5 to 9.8, and with median weight of 2.6 kilograms, ranging from 1.5 to 3.2. Cardiac surgery and pre-operative assisted ventilation were hazardous factors leading to death. In the surgery group, cumulative survival rates at 1 month, 6 months, 12 months, and 24 months were 63%, 38%, 25%, and 22%, respectively, compared with 51%, 26%, 9%, and 9% in the conservative group. There was a significant difference (p = 0.002). The cumulative rates of discharge alive at 1 month, 3 months, and 6 months were 0%, 12%, and 65% in the surgery group, which did not differ from the conservative group (p = 0.80).
Cardiac surgery contributed to increased survival rate but not the rate of discharge alive in trisomy 18 patients. Cardiac surgery could not prevent all the trisomy 18 patients from death. The indication of cardiac surgery should be carefully individualised to improve the quality of life in trisomy 18 patients and concerned surrounding people.</description><identifier>ISSN: 1047-9511</identifier><identifier>EISSN: 1467-1107</identifier><identifier>DOI: 10.1017/S1047951110001848</identifier><identifier>PMID: 21205409</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Cardiac Surgical Procedures ; Chromosomes, Human, Pair 18 - genetics ; Data collection ; Female ; Heart Defects, Congenital - genetics ; Heart Defects, Congenital - mortality ; Heart Defects, Congenital - surgery ; Hospital Mortality - trends ; Humans ; Infant ; Infant, Newborn ; Japan - epidemiology ; Male ; Mortality ; Pulmonary arteries ; Retrospective Studies ; Statistical analysis ; Studies ; Surgery ; Survival Rate - trends ; Treatment Outcome ; Trisomy - genetics ; Ventilation</subject><ispartof>Cardiology in the young, 2011-04, Vol.21 (2), p.209-215</ispartof><rights>Copyright © Cambridge University Press 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-47558fe5607c90381a93decf311c43d0ce8af9afc6947a7c7f33d19a5fb458953</citedby><cites>FETCH-LOGICAL-c393t-47558fe5607c90381a93decf311c43d0ce8af9afc6947a7c7f33d19a5fb458953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21205409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muneuchi, Jun</creatorcontrib><creatorcontrib>Yamamoto, Junko</creatorcontrib><creatorcontrib>Takahashi, Yasuhiko</creatorcontrib><creatorcontrib>Watanabe, Mamie</creatorcontrib><creatorcontrib>Yuge, Tetsuji</creatorcontrib><creatorcontrib>Ohno, Takuro</creatorcontrib><creatorcontrib>Imoto, Yutaka</creatorcontrib><creatorcontrib>Sese, Akira</creatorcontrib><creatorcontrib>Joo, Kunitaka</creatorcontrib><title>Outcomes of cardiac surgery in trisomy 18 patients</title><title>Cardiology in the young</title><addtitle>Cardiol Young</addtitle><description>The objective was to clarify the outcomes of cardiac surgery in trisomy 18 patients.
We analysed 34 consecutive trisomy 18 patients, of whom 21 were males, with cardiac complications. They were divided into patients who underwent cardiac surgery and those who were conservatively treated. We compared rates of survival and discharge alive between two groups.
The surgery group included nine patients, with six males, who underwent cardiac surgery - intracardiac repair in three patients, pulmonary arterial banding in five patients, and ligation of the ductus in one patient - at median age of 2.2 months, ranging from 0.5 to 9.8, and with median weight of 2.6 kilograms, ranging from 1.5 to 3.2. Cardiac surgery and pre-operative assisted ventilation were hazardous factors leading to death. In the surgery group, cumulative survival rates at 1 month, 6 months, 12 months, and 24 months were 63%, 38%, 25%, and 22%, respectively, compared with 51%, 26%, 9%, and 9% in the conservative group. There was a significant difference (p = 0.002). The cumulative rates of discharge alive at 1 month, 3 months, and 6 months were 0%, 12%, and 65% in the surgery group, which did not differ from the conservative group (p = 0.80).
Cardiac surgery contributed to increased survival rate but not the rate of discharge alive in trisomy 18 patients. Cardiac surgery could not prevent all the trisomy 18 patients from death. The indication of cardiac surgery should be carefully individualised to improve the quality of life in trisomy 18 patients and concerned surrounding people.</description><subject>Cardiac Surgical Procedures</subject><subject>Chromosomes, Human, Pair 18 - genetics</subject><subject>Data collection</subject><subject>Female</subject><subject>Heart Defects, Congenital - genetics</subject><subject>Heart Defects, Congenital - mortality</subject><subject>Heart Defects, Congenital - surgery</subject><subject>Hospital Mortality - trends</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Mortality</subject><subject>Pulmonary arteries</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Survival Rate - trends</subject><subject>Treatment Outcome</subject><subject>Trisomy - genetics</subject><subject>Ventilation</subject><issn>1047-9511</issn><issn>1467-1107</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNplkD9PwzAQxS0EolD4ACzIYmEK3MV2bI-o4p9UqQMwR65jo1RNXOxk6LfHVQsDTHe693unp0fIFcIdAsr7NwQutUBEAEDF1RE5Q17JIh_kcd6zXOz0CTlPaZUZxhBOyaTEEgQHfUbKxTjY0LlEg6fWxKY1lqYxfrq4pW1Ph9im0G0pKroxQ-v6IV2QE2_WyV0e5pR8PD2-z16K-eL5dfYwLyzTbCi4FEJ5JyqQVgNTaDRrnPUM0XLWgHXKeG28rTSXRlrpGWtQG-GXXCgt2JTc7v9uYvgaXRrqrk3Wrdemd2FMtRKMSxDVjrz5Q67CGPscLkOlVjlClSHcQzaGlKLz9Sa2nYnbGqHe1Vn_qzN7rg-Px2Xnml_HT3_sG-4AbU4</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Muneuchi, Jun</creator><creator>Yamamoto, Junko</creator><creator>Takahashi, Yasuhiko</creator><creator>Watanabe, Mamie</creator><creator>Yuge, Tetsuji</creator><creator>Ohno, Takuro</creator><creator>Imoto, Yutaka</creator><creator>Sese, Akira</creator><creator>Joo, Kunitaka</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Outcomes of cardiac surgery in trisomy 18 patients</title><author>Muneuchi, Jun ; Yamamoto, Junko ; Takahashi, Yasuhiko ; Watanabe, Mamie ; Yuge, Tetsuji ; Ohno, Takuro ; Imoto, Yutaka ; Sese, Akira ; Joo, Kunitaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-47558fe5607c90381a93decf311c43d0ce8af9afc6947a7c7f33d19a5fb458953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Cardiac Surgical Procedures</topic><topic>Chromosomes, Human, Pair 18 - genetics</topic><topic>Data collection</topic><topic>Female</topic><topic>Heart Defects, Congenital - genetics</topic><topic>Heart Defects, Congenital - mortality</topic><topic>Heart Defects, Congenital - surgery</topic><topic>Hospital Mortality - trends</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Mortality</topic><topic>Pulmonary arteries</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Surgery</topic><topic>Survival Rate - trends</topic><topic>Treatment Outcome</topic><topic>Trisomy - genetics</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muneuchi, Jun</creatorcontrib><creatorcontrib>Yamamoto, Junko</creatorcontrib><creatorcontrib>Takahashi, Yasuhiko</creatorcontrib><creatorcontrib>Watanabe, Mamie</creatorcontrib><creatorcontrib>Yuge, Tetsuji</creatorcontrib><creatorcontrib>Ohno, Takuro</creatorcontrib><creatorcontrib>Imoto, Yutaka</creatorcontrib><creatorcontrib>Sese, Akira</creatorcontrib><creatorcontrib>Joo, Kunitaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiology in the young</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muneuchi, Jun</au><au>Yamamoto, Junko</au><au>Takahashi, Yasuhiko</au><au>Watanabe, Mamie</au><au>Yuge, Tetsuji</au><au>Ohno, Takuro</au><au>Imoto, Yutaka</au><au>Sese, Akira</au><au>Joo, Kunitaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes of cardiac surgery in trisomy 18 patients</atitle><jtitle>Cardiology in the young</jtitle><addtitle>Cardiol Young</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>21</volume><issue>2</issue><spage>209</spage><epage>215</epage><pages>209-215</pages><issn>1047-9511</issn><eissn>1467-1107</eissn><abstract>The objective was to clarify the outcomes of cardiac surgery in trisomy 18 patients.
We analysed 34 consecutive trisomy 18 patients, of whom 21 were males, with cardiac complications. They were divided into patients who underwent cardiac surgery and those who were conservatively treated. We compared rates of survival and discharge alive between two groups.
The surgery group included nine patients, with six males, who underwent cardiac surgery - intracardiac repair in three patients, pulmonary arterial banding in five patients, and ligation of the ductus in one patient - at median age of 2.2 months, ranging from 0.5 to 9.8, and with median weight of 2.6 kilograms, ranging from 1.5 to 3.2. Cardiac surgery and pre-operative assisted ventilation were hazardous factors leading to death. In the surgery group, cumulative survival rates at 1 month, 6 months, 12 months, and 24 months were 63%, 38%, 25%, and 22%, respectively, compared with 51%, 26%, 9%, and 9% in the conservative group. There was a significant difference (p = 0.002). The cumulative rates of discharge alive at 1 month, 3 months, and 6 months were 0%, 12%, and 65% in the surgery group, which did not differ from the conservative group (p = 0.80).
Cardiac surgery contributed to increased survival rate but not the rate of discharge alive in trisomy 18 patients. Cardiac surgery could not prevent all the trisomy 18 patients from death. The indication of cardiac surgery should be carefully individualised to improve the quality of life in trisomy 18 patients and concerned surrounding people.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>21205409</pmid><doi>10.1017/S1047951110001848</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cardiology in the young, 2011-04, Vol.21 (2), p.209-215 |
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| source | MEDLINE; Cambridge Journals |
| subjects | Cardiac Surgical Procedures Chromosomes, Human, Pair 18 - genetics Data collection Female Heart Defects, Congenital - genetics Heart Defects, Congenital - mortality Heart Defects, Congenital - surgery Hospital Mortality - trends Humans Infant Infant, Newborn Japan - epidemiology Male Mortality Pulmonary arteries Retrospective Studies Statistical analysis Studies Surgery Survival Rate - trends Treatment Outcome Trisomy - genetics Ventilation |
| title | Outcomes of cardiac surgery in trisomy 18 patients |
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