Glycosyltransferase activity of Fringe modulates Notch–Delta interactions

Ligands that are capable of activating Notch family receptors are broadly expressed in animal development, but their activity is tightly regulated to allow formation of tissue boundaries 1 . Members of the fringe gene family have been implicated in limiting Notch activation during boundary formation...

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Veröffentlicht in:	Nature (London) 2000-07, Vol.406 (6794), p.411-415
Hauptverfasser:	Brückner, Katja, Perez, Lidia, Clausen, Henrik, Cohen, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals Binding Sites Biological and medical sciences Boundaries Cell interactions, adhesion Cells, Cultured Cloning, Molecular Delta protein Drosophila Drosophila Proteins Enzymes Epidermal Growth Factor - metabolism Fringe protein Fucose - metabolism Fundamental and applied biological sciences. Psychology Genes Glycosyltransferase Glycosyltransferases - genetics Glycosyltransferases - metabolism Golgi Apparatus - metabolism Humanities and Social Sciences Insect Proteins - genetics Insect Proteins - metabolism Intracellular Signaling Peptides and Proteins letter Membrane Proteins - genetics Membrane Proteins - metabolism Molecular and cellular biology Molecular biology multidisciplinary N-Acetylglucosaminyltransferases Notch protein Prenatal development Protein Binding Protein Structure, Tertiary Proteins Receptors, Notch Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Repetitive Sequences, Amino Acid Science Science (multidisciplinary)
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