A model for cell motility on soft bio-adhesive substrates

Abstract Mechanical stiffness of bio-adhesive substrates has been recognized as a major regulator of cell motility. We present a simple physical model to study the crawling locomotion of a contractile cell on a soft elastic substrate. The mechanism of rigidity sensing is accounted for using Schwarz&...

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Veröffentlicht in:	Journal of biomechanics 2011-02, Vol.44 (4), p.755-758
1. Verfasser:	Sarvestani, Alireza S
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - physiology Adhesion Anchorages Animals Asymmetry Biological and medical sciences Biomechanics. Biorheology Cell Adhesion - physiology Cell motility Cell Movement - physiology Cell physiology Computer Simulation Control Cytoskeleton Fundamental and applied biological sciences. Psychology Humans Locomotion Mathematical models Modeling Models, Biological Molecular and cellular biology Molecular Motor Proteins - physiology Motility and taxis Myosins - physiology Physical Medicine and Rehabilitation Regulators Rigidity Stiffness Substrate stiffness Tissues, organs and organisms biophysics Traction
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