Ghrelin, leptin and adiponectin as possible predictors of the hedonic value of odors
Several lines of evidence point to a close relationship between the hormones of energy homeostasis and the olfactory system. Examples are the localization of leptin and adiponectin receptors in the olfactory system or increased activation of brain regions related to the palatability and the hedonic...
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| Veröffentlicht in: | Regulatory peptides 2011-02, Vol.167 (1), p.112-117 |
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| creator | Trellakis, Sokratis Tagay, Sefik Fischer, Cornelia Rydleuskaya, Alena Scherag, André Bruderek, Kirsten Schlegl, Sandra Greve, Jens Canbay, Ali E. Lang, Stephan Brandau, Sven |
| description | Several lines of evidence point to a close relationship between the hormones of energy homeostasis and the olfactory system. Examples are the localization of leptin and adiponectin receptors in the olfactory system or increased activation of brain regions related to the palatability and the hedonic value of food in response to food pictures after application of ghrelin.
In this preliminary study, we tested in 31 subjects (17 male and 14 female) if and to what extent the peripheral blood concentrations of “satiety” hormones, such as leptin, adiponectin, and ghrelin (acyl and total), are correlated with the self-ratings of odor pleasantness and with the objective olfactory and gustatory ability.
The hedonic values of some odors were found to be differently rated between donors depending on gender and body weight. The concentrations of leptin, adiponectin and total ghrelin were significantly associated with the hedonic value of pepper black oil, but failed to show significant correlations for 5 other odors tested. Except for a significant association between leptin and odor identification, hormone concentrations were not linked to the abilities of smell and taste.
Peripheral adipokines and gut hormones may alter the perception and pleasantness of specific odors, presumably either directly through their receptors in the olfactory system or indirectly through central interfaces between the regulation systems of olfaction, appetite control, memory and motivation.
►Pleasantness of odors may depend on gender and body weight. ►Pleasantness of specific odors may be associated with leptin, adiponectin and ghrelin. ►Peripheral leptin may be linked with the ability of odor identification. ►A close relationship between adipokines, gut hormones and the olfactory system. |
| doi_str_mv | 10.1016/j.regpep.2010.12.005 |
| format | Article |
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In this preliminary study, we tested in 31 subjects (17 male and 14 female) if and to what extent the peripheral blood concentrations of “satiety” hormones, such as leptin, adiponectin, and ghrelin (acyl and total), are correlated with the self-ratings of odor pleasantness and with the objective olfactory and gustatory ability.
The hedonic values of some odors were found to be differently rated between donors depending on gender and body weight. The concentrations of leptin, adiponectin and total ghrelin were significantly associated with the hedonic value of pepper black oil, but failed to show significant correlations for 5 other odors tested. Except for a significant association between leptin and odor identification, hormone concentrations were not linked to the abilities of smell and taste.
Peripheral adipokines and gut hormones may alter the perception and pleasantness of specific odors, presumably either directly through their receptors in the olfactory system or indirectly through central interfaces between the regulation systems of olfaction, appetite control, memory and motivation.
►Pleasantness of odors may depend on gender and body weight. ►Pleasantness of specific odors may be associated with leptin, adiponectin and ghrelin. ►Peripheral leptin may be linked with the ability of odor identification. ►A close relationship between adipokines, gut hormones and the olfactory system.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/j.regpep.2010.12.005</identifier><identifier>PMID: 21185875</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Adiponectin - biosynthesis ; Adiponectin - blood ; Adult ; Appetite Regulation ; Biological and medical sciences ; Body Weight ; Brain - physiology ; Energy Metabolism ; Feeding Behavior - physiology ; Feeding Behavior - psychology ; Female ; Fundamental and applied biological sciences. Psychology ; Ghrelin ; Ghrelin - biosynthesis ; Ghrelin - blood ; Humans ; Leptin ; Leptin - biosynthesis ; Leptin - blood ; Male ; Medical sciences ; Memory ; Metabolic diseases ; Motivation ; Obesity ; Obesity - prevention & control ; Odor pleasantness ; Odorants - analysis ; Olfactory ; Olfactory Pathways - metabolism ; Piper nigrum - metabolism ; Plant Oils - metabolism ; Predictive Value of Tests ; Satiation ; Sex Factors ; Smell - physiology ; Taste - physiology ; Taste Perception - physiology ; Vertebrates: endocrinology</subject><ispartof>Regulatory peptides, 2011-02, Vol.167 (1), p.112-117</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-148f4bb63ef8dd37f959ca9ab6493e62c3e85925ad42b1fa89a4c8c2cc54a1fb3</citedby><cites>FETCH-LOGICAL-c490t-148f4bb63ef8dd37f959ca9ab6493e62c3e85925ad42b1fa89a4c8c2cc54a1fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.regpep.2010.12.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23923934$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21185875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trellakis, Sokratis</creatorcontrib><creatorcontrib>Tagay, Sefik</creatorcontrib><creatorcontrib>Fischer, Cornelia</creatorcontrib><creatorcontrib>Rydleuskaya, Alena</creatorcontrib><creatorcontrib>Scherag, André</creatorcontrib><creatorcontrib>Bruderek, Kirsten</creatorcontrib><creatorcontrib>Schlegl, Sandra</creatorcontrib><creatorcontrib>Greve, Jens</creatorcontrib><creatorcontrib>Canbay, Ali E.</creatorcontrib><creatorcontrib>Lang, Stephan</creatorcontrib><creatorcontrib>Brandau, Sven</creatorcontrib><title>Ghrelin, leptin and adiponectin as possible predictors of the hedonic value of odors</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>Several lines of evidence point to a close relationship between the hormones of energy homeostasis and the olfactory system. Examples are the localization of leptin and adiponectin receptors in the olfactory system or increased activation of brain regions related to the palatability and the hedonic value of food in response to food pictures after application of ghrelin.
In this preliminary study, we tested in 31 subjects (17 male and 14 female) if and to what extent the peripheral blood concentrations of “satiety” hormones, such as leptin, adiponectin, and ghrelin (acyl and total), are correlated with the self-ratings of odor pleasantness and with the objective olfactory and gustatory ability.
The hedonic values of some odors were found to be differently rated between donors depending on gender and body weight. The concentrations of leptin, adiponectin and total ghrelin were significantly associated with the hedonic value of pepper black oil, but failed to show significant correlations for 5 other odors tested. Except for a significant association between leptin and odor identification, hormone concentrations were not linked to the abilities of smell and taste.
Peripheral adipokines and gut hormones may alter the perception and pleasantness of specific odors, presumably either directly through their receptors in the olfactory system or indirectly through central interfaces between the regulation systems of olfaction, appetite control, memory and motivation.
►Pleasantness of odors may depend on gender and body weight. ►Pleasantness of specific odors may be associated with leptin, adiponectin and ghrelin. ►Peripheral leptin may be linked with the ability of odor identification. ►A close relationship between adipokines, gut hormones and the olfactory system.</description><subject>Adiponectin - biosynthesis</subject><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Appetite Regulation</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Brain - physiology</subject><subject>Energy Metabolism</subject><subject>Feeding Behavior - physiology</subject><subject>Feeding Behavior - psychology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ghrelin</subject><subject>Ghrelin - biosynthesis</subject><subject>Ghrelin - blood</subject><subject>Humans</subject><subject>Leptin</subject><subject>Leptin - biosynthesis</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Metabolic diseases</subject><subject>Motivation</subject><subject>Obesity</subject><subject>Obesity - prevention & control</subject><subject>Odor pleasantness</subject><subject>Odorants - analysis</subject><subject>Olfactory</subject><subject>Olfactory Pathways - metabolism</subject><subject>Piper nigrum - metabolism</subject><subject>Plant Oils - metabolism</subject><subject>Predictive Value of Tests</subject><subject>Satiation</subject><subject>Sex Factors</subject><subject>Smell - physiology</subject><subject>Taste - physiology</subject><subject>Taste Perception - physiology</subject><subject>Vertebrates: endocrinology</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctq3DAUQEVpaCbT_kEI2pRmEU_1tOVNoYTmAYFskrWQpauOBo_lSJ5A_j5yZ5rsAgKhq3MfOkLolJIVJbT-uVkl-DvCuGJkDrEVIfITWlDV8IrWqv6MFgVrKkKpPEYnOW8IobJp-Bd0zChVUjVygR6u1wn6MFzgHsYpDNgMDhsXxjiA_XfOeIw5h64HPCZwwU4xZRw9ntaA1-DiECx-Nv0O5mB05fYrOvKmz_DtsC_R49Wfh8ub6u7--vby911lRUumigrlRdfVHLxyjje-la01relq0XKomeWgZMukcYJ11BvVGmGVZdZKYajv-BL92NcdU3zaQZ70NmQLfW8GiLusleSMCVaqLdH5hyQlRCkhuRAFFXvUpvLuBF6PKWxNeimQns3rjd6b17N5TZku5kva2aHDrtuCe0v6r7oA3w-Aydb0PpnBhvzO8bYsPvf_teegmHsOkHS2AQZb1KfyJdrF8PEkr3aYo4M</recordid><startdate>20110225</startdate><enddate>20110225</enddate><creator>Trellakis, Sokratis</creator><creator>Tagay, Sefik</creator><creator>Fischer, Cornelia</creator><creator>Rydleuskaya, Alena</creator><creator>Scherag, André</creator><creator>Bruderek, Kirsten</creator><creator>Schlegl, Sandra</creator><creator>Greve, Jens</creator><creator>Canbay, Ali E.</creator><creator>Lang, Stephan</creator><creator>Brandau, Sven</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20110225</creationdate><title>Ghrelin, leptin and adiponectin as possible predictors of the hedonic value of odors</title><author>Trellakis, Sokratis ; Tagay, Sefik ; Fischer, Cornelia ; Rydleuskaya, Alena ; Scherag, André ; Bruderek, Kirsten ; Schlegl, Sandra ; Greve, Jens ; Canbay, Ali E. ; Lang, Stephan ; Brandau, Sven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-148f4bb63ef8dd37f959ca9ab6493e62c3e85925ad42b1fa89a4c8c2cc54a1fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adiponectin - biosynthesis</topic><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Appetite Regulation</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Brain - physiology</topic><topic>Energy Metabolism</topic><topic>Feeding Behavior - physiology</topic><topic>Feeding Behavior - psychology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ghrelin</topic><topic>Ghrelin - biosynthesis</topic><topic>Ghrelin - blood</topic><topic>Humans</topic><topic>Leptin</topic><topic>Leptin - biosynthesis</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Metabolic diseases</topic><topic>Motivation</topic><topic>Obesity</topic><topic>Obesity - prevention & control</topic><topic>Odor pleasantness</topic><topic>Odorants - analysis</topic><topic>Olfactory</topic><topic>Olfactory Pathways - metabolism</topic><topic>Piper nigrum - metabolism</topic><topic>Plant Oils - metabolism</topic><topic>Predictive Value of Tests</topic><topic>Satiation</topic><topic>Sex Factors</topic><topic>Smell - physiology</topic><topic>Taste - physiology</topic><topic>Taste Perception - physiology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trellakis, Sokratis</creatorcontrib><creatorcontrib>Tagay, Sefik</creatorcontrib><creatorcontrib>Fischer, Cornelia</creatorcontrib><creatorcontrib>Rydleuskaya, Alena</creatorcontrib><creatorcontrib>Scherag, André</creatorcontrib><creatorcontrib>Bruderek, Kirsten</creatorcontrib><creatorcontrib>Schlegl, Sandra</creatorcontrib><creatorcontrib>Greve, Jens</creatorcontrib><creatorcontrib>Canbay, Ali E.</creatorcontrib><creatorcontrib>Lang, Stephan</creatorcontrib><creatorcontrib>Brandau, Sven</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trellakis, Sokratis</au><au>Tagay, Sefik</au><au>Fischer, Cornelia</au><au>Rydleuskaya, Alena</au><au>Scherag, André</au><au>Bruderek, Kirsten</au><au>Schlegl, Sandra</au><au>Greve, Jens</au><au>Canbay, Ali E.</au><au>Lang, Stephan</au><au>Brandau, Sven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ghrelin, leptin and adiponectin as possible predictors of the hedonic value of odors</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>2011-02-25</date><risdate>2011</risdate><volume>167</volume><issue>1</issue><spage>112</spage><epage>117</epage><pages>112-117</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>Several lines of evidence point to a close relationship between the hormones of energy homeostasis and the olfactory system. Examples are the localization of leptin and adiponectin receptors in the olfactory system or increased activation of brain regions related to the palatability and the hedonic value of food in response to food pictures after application of ghrelin.
In this preliminary study, we tested in 31 subjects (17 male and 14 female) if and to what extent the peripheral blood concentrations of “satiety” hormones, such as leptin, adiponectin, and ghrelin (acyl and total), are correlated with the self-ratings of odor pleasantness and with the objective olfactory and gustatory ability.
The hedonic values of some odors were found to be differently rated between donors depending on gender and body weight. The concentrations of leptin, adiponectin and total ghrelin were significantly associated with the hedonic value of pepper black oil, but failed to show significant correlations for 5 other odors tested. Except for a significant association between leptin and odor identification, hormone concentrations were not linked to the abilities of smell and taste.
Peripheral adipokines and gut hormones may alter the perception and pleasantness of specific odors, presumably either directly through their receptors in the olfactory system or indirectly through central interfaces between the regulation systems of olfaction, appetite control, memory and motivation.
►Pleasantness of odors may depend on gender and body weight. ►Pleasantness of specific odors may be associated with leptin, adiponectin and ghrelin. ►Peripheral leptin may be linked with the ability of odor identification. ►A close relationship between adipokines, gut hormones and the olfactory system.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>21185875</pmid><doi>10.1016/j.regpep.2010.12.005</doi><tpages>6</tpages></addata></record> |
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| subjects | Adiponectin - biosynthesis Adiponectin - blood Adult Appetite Regulation Biological and medical sciences Body Weight Brain - physiology Energy Metabolism Feeding Behavior - physiology Feeding Behavior - psychology Female Fundamental and applied biological sciences. Psychology Ghrelin Ghrelin - biosynthesis Ghrelin - blood Humans Leptin Leptin - biosynthesis Leptin - blood Male Medical sciences Memory Metabolic diseases Motivation Obesity Obesity - prevention & control Odor pleasantness Odorants - analysis Olfactory Olfactory Pathways - metabolism Piper nigrum - metabolism Plant Oils - metabolism Predictive Value of Tests Satiation Sex Factors Smell - physiology Taste - physiology Taste Perception - physiology Vertebrates: endocrinology |
| title | Ghrelin, leptin and adiponectin as possible predictors of the hedonic value of odors |
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