Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification

Summary Background Dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) is utilized to successfully treat dermatological conditions. This study monitored fluorescence changes attributed to the accumulation and destruction of the photosensitizer, protoporphyrin IX (PpIX), at several d...

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Veröffentlicht in:	Photodiagnosis and photodynamic therapy 2011-03, Vol.8 (1), p.30-38
Hauptverfasser:	Tyrrell, Jessica, Campbell, Sandra M, Curnow, Alison, BSc (Hons), PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aminolevulinic Acid - administration & dosage Aminolevulinic Acid - analogs & derivatives Aminolevulinic Acid - pharmacokinetics Dermatology Drug Combinations Female Fluorescence imaging Hematology, Oncology and Palliative Medicine Humans Internal Medicine Male Metabolic Clearance Rate - drug effects Methyl-aminolevulinate Microscopy, Fluorescence - methods Middle Aged Organ Specificity - drug effects Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - administration & dosage Photosensitizing Agents - pharmacokinetics Protoporphyrin IX Protoporphyrins - administration & dosage Protoporphyrins - pharmacokinetics Skin Neoplasms - diagnosis Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology Spectrometry, Fluorescence - methods Tissue Distribution - drug effects Treatment Outcome
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