Aging Linked to Type 2 Diabetes Increases Oxidative Stress and Chronic Inflammation
Oxidative stress (OxS) and inflammation are physiopathological mechanisms related to diabetes and aging. We evaluated the additive effect of diabetes and aging on OxS and inflammation in a cross-sectional comparative study of 228 subjects: (1) 56 healthy adults (mean age, 47 ± 7 years); (2) 60 diabe...
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| Veröffentlicht in: | Rejuvenation research 2011-02, Vol.14 (1), p.25-31 |
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| creator | Mendoza-Núñez, Víctor Manuel Rosado-Pérez, Juana Santiago-Osorio, Edelmiro Ortiz, Rocío Sánchez-Rodríguez, Martha A. Galván-Duarte, Rosa Elba |
| description | Oxidative stress (OxS) and inflammation are physiopathological mechanisms related to diabetes and aging. We evaluated the additive effect of diabetes and aging on OxS and inflammation in a cross-sectional comparative study of 228 subjects: (1) 56 healthy adults (mean age, 47 ± 7 years); (2) 60 diabetic adults (mean age, 52 ± 6 years); (3) 40 healthy elderly adults (mean age, 67 ± 7 years); and (4) 72 diabetic elderly adults (mean age, 68 ± 7 years). We measured levels of glycosylated hemoglobin (HbA1c), plasma lipid peroxides, superoxide dismutase, glutathione peroxidase, total antioxidants, and tumor necrosis factor-alpha (TNF-α). The results indicate that diabetes is a risk factor for subjects with high serum levels of TNF-α (odds ratio [OR] = 12.1; 95% confidence interval [95% CI], 5.0–28;
p
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| doi_str_mv | 10.1089/rej.2010.1054 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_852912810</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A250471385</galeid><sourcerecordid>A250471385</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-e242a2000c058deb31e9e98181cdf2212aa5c942440c525eefe0e3b544b116173</originalsourceid><addsrcrecordid>eNqFkUtLAzEQgIMoPqpHrxLw4Glrkk262WOpTyh4aD2HbHa2pu5ma7IV--_N2ioIgswhk5lvhoEPoXNKhpTI_NrDcsjI10_wPXRMhcgSKbJsv895ntCR5EfoJIQlISzLhThER4wywkc8P0az8cK6BZ5a9wol7lo836wAM3xjdQEdBPzojAcdYvb0YUvd2XfAs85DCFi7Ek9efOusiVhV66aJ_dadooNK1wHOdu8APd_dzicPyfTp_nEyniaGk7RLgHGmGSHEECFLKFIKOeSSSmrKisUTtRYm54xzYgQTABUQSAvBeUHpiGbpAF1t9658-7aG0KnGBgN1rR2066CkYDllkpJIXm7Jha5BWVe1ndemp9WYCcIzmkoRqeEfVIwSGmtaB5WN9V8DyXbA-DYED5Vaedtov1GUqN6OinZUb0f1diJ_sTt4XTRQ_tDfOiKQboG-rJ2rLRTgu3_WfgIZEJj7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>852912810</pqid></control><display><type>article</type><title>Aging Linked to Type 2 Diabetes Increases Oxidative Stress and Chronic Inflammation</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Mendoza-Núñez, Víctor Manuel ; Rosado-Pérez, Juana ; Santiago-Osorio, Edelmiro ; Ortiz, Rocío ; Sánchez-Rodríguez, Martha A. ; Galván-Duarte, Rosa Elba</creator><creatorcontrib>Mendoza-Núñez, Víctor Manuel ; Rosado-Pérez, Juana ; Santiago-Osorio, Edelmiro ; Ortiz, Rocío ; Sánchez-Rodríguez, Martha A. ; Galván-Duarte, Rosa Elba</creatorcontrib><description>Oxidative stress (OxS) and inflammation are physiopathological mechanisms related to diabetes and aging. We evaluated the additive effect of diabetes and aging on OxS and inflammation in a cross-sectional comparative study of 228 subjects: (1) 56 healthy adults (mean age, 47 ± 7 years); (2) 60 diabetic adults (mean age, 52 ± 6 years); (3) 40 healthy elderly adults (mean age, 67 ± 7 years); and (4) 72 diabetic elderly adults (mean age, 68 ± 7 years). We measured levels of glycosylated hemoglobin (HbA1c), plasma lipid peroxides, superoxide dismutase, glutathione peroxidase, total antioxidants, and tumor necrosis factor-alpha (TNF-α). The results indicate that diabetes is a risk factor for subjects with high serum levels of TNF-α (odds ratio [OR] = 12.1; 95% confidence interval [95% CI], 5.0–28;
p
< 0.001); this correlation becomes stronger when it is also associated with aging (OR = 14; 95% CI, 3.7–53.7;
p
< 0.05). Likewise, we observed that diabetes is an independent risk factor for OxS (OR = 2.1; 95% CI, 1.2–3.8;
p
< 0.05), and a stronger factor in older patients (OR = 3.1; 95% CI, 1.3–7.5;
p
< 0.05). Our findings suggest that aging, in concert with diabetes, exerts an additive effect on OxS and inflammation.</description><identifier>ISSN: 1549-1684</identifier><identifier>EISSN: 1557-8577</identifier><identifier>DOI: 10.1089/rej.2010.1054</identifier><identifier>PMID: 21204649</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Aged ; Aging ; Aging - pathology ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Care and treatment ; Case-Control Studies ; Demographic aspects ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - pathology ; Diagnosis ; Female ; Humans ; Hyperinsulinism - blood ; Hyperinsulinism - complications ; Hyperinsulinism - pathology ; Inflammation ; Inflammation - blood ; Inflammation - complications ; Inflammation - pathology ; Influence ; Interleukin-6 - blood ; Male ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Metabolic Syndrome - pathology ; Middle Aged ; Original Articles ; Oxidative Stress ; Physiological aspects ; Risk Factors ; Tumor Necrosis Factor-alpha - blood ; Type 2 diabetes</subject><ispartof>Rejuvenation research, 2011-02, Vol.14 (1), p.25-31</ispartof><rights>2011, Mary Ann Liebert, Inc.</rights><rights>COPYRIGHT 2011 Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-e242a2000c058deb31e9e98181cdf2212aa5c942440c525eefe0e3b544b116173</citedby><cites>FETCH-LOGICAL-c403t-e242a2000c058deb31e9e98181cdf2212aa5c942440c525eefe0e3b544b116173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21204649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mendoza-Núñez, Víctor Manuel</creatorcontrib><creatorcontrib>Rosado-Pérez, Juana</creatorcontrib><creatorcontrib>Santiago-Osorio, Edelmiro</creatorcontrib><creatorcontrib>Ortiz, Rocío</creatorcontrib><creatorcontrib>Sánchez-Rodríguez, Martha A.</creatorcontrib><creatorcontrib>Galván-Duarte, Rosa Elba</creatorcontrib><title>Aging Linked to Type 2 Diabetes Increases Oxidative Stress and Chronic Inflammation</title><title>Rejuvenation research</title><addtitle>Rejuvenation Res</addtitle><description>Oxidative stress (OxS) and inflammation are physiopathological mechanisms related to diabetes and aging. We evaluated the additive effect of diabetes and aging on OxS and inflammation in a cross-sectional comparative study of 228 subjects: (1) 56 healthy adults (mean age, 47 ± 7 years); (2) 60 diabetic adults (mean age, 52 ± 6 years); (3) 40 healthy elderly adults (mean age, 67 ± 7 years); and (4) 72 diabetic elderly adults (mean age, 68 ± 7 years). We measured levels of glycosylated hemoglobin (HbA1c), plasma lipid peroxides, superoxide dismutase, glutathione peroxidase, total antioxidants, and tumor necrosis factor-alpha (TNF-α). The results indicate that diabetes is a risk factor for subjects with high serum levels of TNF-α (odds ratio [OR] = 12.1; 95% confidence interval [95% CI], 5.0–28;
p
< 0.001); this correlation becomes stronger when it is also associated with aging (OR = 14; 95% CI, 3.7–53.7;
p
< 0.05). Likewise, we observed that diabetes is an independent risk factor for OxS (OR = 2.1; 95% CI, 1.2–3.8;
p
< 0.05), and a stronger factor in older patients (OR = 3.1; 95% CI, 1.3–7.5;
p
< 0.05). Our findings suggest that aging, in concert with diabetes, exerts an additive effect on OxS and inflammation.</description><subject>Aged</subject><subject>Aging</subject><subject>Aging - pathology</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Demographic aspects</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperinsulinism - blood</subject><subject>Hyperinsulinism - complications</subject><subject>Hyperinsulinism - pathology</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - complications</subject><subject>Inflammation - pathology</subject><subject>Influence</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - pathology</subject><subject>Middle Aged</subject><subject>Original Articles</subject><subject>Oxidative Stress</subject><subject>Physiological aspects</subject><subject>Risk Factors</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Type 2 diabetes</subject><issn>1549-1684</issn><issn>1557-8577</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEQgIMoPqpHrxLw4Glrkk262WOpTyh4aD2HbHa2pu5ma7IV--_N2ioIgswhk5lvhoEPoXNKhpTI_NrDcsjI10_wPXRMhcgSKbJsv895ntCR5EfoJIQlISzLhThER4wywkc8P0az8cK6BZ5a9wol7lo836wAM3xjdQEdBPzojAcdYvb0YUvd2XfAs85DCFi7Ek9efOusiVhV66aJ_dadooNK1wHOdu8APd_dzicPyfTp_nEyniaGk7RLgHGmGSHEECFLKFIKOeSSSmrKisUTtRYm54xzYgQTABUQSAvBeUHpiGbpAF1t9658-7aG0KnGBgN1rR2066CkYDllkpJIXm7Jha5BWVe1ndemp9WYCcIzmkoRqeEfVIwSGmtaB5WN9V8DyXbA-DYED5Vaedtov1GUqN6OinZUb0f1diJ_sTt4XTRQ_tDfOiKQboG-rJ2rLRTgu3_WfgIZEJj7</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Mendoza-Núñez, Víctor Manuel</creator><creator>Rosado-Pérez, Juana</creator><creator>Santiago-Osorio, Edelmiro</creator><creator>Ortiz, Rocío</creator><creator>Sánchez-Rodríguez, Martha A.</creator><creator>Galván-Duarte, Rosa Elba</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Aging Linked to Type 2 Diabetes Increases Oxidative Stress and Chronic Inflammation</title><author>Mendoza-Núñez, Víctor Manuel ; Rosado-Pérez, Juana ; Santiago-Osorio, Edelmiro ; Ortiz, Rocío ; Sánchez-Rodríguez, Martha A. ; Galván-Duarte, Rosa Elba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-e242a2000c058deb31e9e98181cdf2212aa5c942440c525eefe0e3b544b116173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Aging - pathology</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Demographic aspects</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperinsulinism - blood</topic><topic>Hyperinsulinism - complications</topic><topic>Hyperinsulinism - pathology</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation - complications</topic><topic>Inflammation - pathology</topic><topic>Influence</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - pathology</topic><topic>Middle Aged</topic><topic>Original Articles</topic><topic>Oxidative Stress</topic><topic>Physiological aspects</topic><topic>Risk Factors</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mendoza-Núñez, Víctor Manuel</creatorcontrib><creatorcontrib>Rosado-Pérez, Juana</creatorcontrib><creatorcontrib>Santiago-Osorio, Edelmiro</creatorcontrib><creatorcontrib>Ortiz, Rocío</creatorcontrib><creatorcontrib>Sánchez-Rodríguez, Martha A.</creatorcontrib><creatorcontrib>Galván-Duarte, Rosa Elba</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rejuvenation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mendoza-Núñez, Víctor Manuel</au><au>Rosado-Pérez, Juana</au><au>Santiago-Osorio, Edelmiro</au><au>Ortiz, Rocío</au><au>Sánchez-Rodríguez, Martha A.</au><au>Galván-Duarte, Rosa Elba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging Linked to Type 2 Diabetes Increases Oxidative Stress and Chronic Inflammation</atitle><jtitle>Rejuvenation research</jtitle><addtitle>Rejuvenation Res</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>14</volume><issue>1</issue><spage>25</spage><epage>31</epage><pages>25-31</pages><issn>1549-1684</issn><eissn>1557-8577</eissn><abstract>Oxidative stress (OxS) and inflammation are physiopathological mechanisms related to diabetes and aging. We evaluated the additive effect of diabetes and aging on OxS and inflammation in a cross-sectional comparative study of 228 subjects: (1) 56 healthy adults (mean age, 47 ± 7 years); (2) 60 diabetic adults (mean age, 52 ± 6 years); (3) 40 healthy elderly adults (mean age, 67 ± 7 years); and (4) 72 diabetic elderly adults (mean age, 68 ± 7 years). We measured levels of glycosylated hemoglobin (HbA1c), plasma lipid peroxides, superoxide dismutase, glutathione peroxidase, total antioxidants, and tumor necrosis factor-alpha (TNF-α). The results indicate that diabetes is a risk factor for subjects with high serum levels of TNF-α (odds ratio [OR] = 12.1; 95% confidence interval [95% CI], 5.0–28;
p
< 0.001); this correlation becomes stronger when it is also associated with aging (OR = 14; 95% CI, 3.7–53.7;
p
< 0.05). Likewise, we observed that diabetes is an independent risk factor for OxS (OR = 2.1; 95% CI, 1.2–3.8;
p
< 0.05), and a stronger factor in older patients (OR = 3.1; 95% CI, 1.3–7.5;
p
< 0.05). Our findings suggest that aging, in concert with diabetes, exerts an additive effect on OxS and inflammation.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>21204649</pmid><doi>10.1089/rej.2010.1054</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aging Aging - pathology Biomarkers - blood C-Reactive Protein - metabolism Care and treatment Case-Control Studies Demographic aspects Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - pathology Diagnosis Female Humans Hyperinsulinism - blood Hyperinsulinism - complications Hyperinsulinism - pathology Inflammation Inflammation - blood Inflammation - complications Inflammation - pathology Influence Interleukin-6 - blood Male Metabolic Syndrome - blood Metabolic Syndrome - complications Metabolic Syndrome - pathology Middle Aged Original Articles Oxidative Stress Physiological aspects Risk Factors Tumor Necrosis Factor-alpha - blood Type 2 diabetes |
| title | Aging Linked to Type 2 Diabetes Increases Oxidative Stress and Chronic Inflammation |
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