Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation
Objectives The objective of this study was to evaluate the effects of different lesion sets of ablation in patients undergoing mitral surgery plus maze. Background The role of lesion sets on outcome after maze is poorly defined. Methods A total of 141 patients were prospectively followed up. Two dif...
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creator | Onorati, Francesco, MD, PhD Mariscalco, Giovanni, MD, PhD Rubino, Antonino Salvatore, MD Serraino, Filiberto, MD Santini, Francesco, MD Musazzi, Andrea, MD Klersy, Catherine, MD Sala, Andrea, MD Renzulli, Attilio, MD, PhD |
description | Objectives The objective of this study was to evaluate the effects of different lesion sets of ablation in patients undergoing mitral surgery plus maze. Background The role of lesion sets on outcome after maze is poorly defined. Methods A total of 141 patients were prospectively followed up. Two different lesion sets were prepared: 32 patients underwent a radiofrequency left atrial lesion set of maze (“limited”), and 109 had combined left and right atrial lesion sets of maze ± ganglionic plexi isolation (“extensive”). A longitudinal observational study assessed the role of “extensive” versus “limited” ablation on atrial fibrillation (AF), New York Heart Association (NYHA) functional class II/III, treatment with antiarrhythmic drugs, follow-up recovery of the ratio of E- to A-wave (E/A), and survival and time to hospitalization (overall and for heart failure). Results The prevalence of AF over time was lower in the “extensive” arm (adjusted relative risk [RR]: 0.10; 95% confidence interval [CI]: 0.03 to 0.31; p < 0.001), with significantly lower prevalence at discharge, 3 months, and 18 months. The prevalence of patients in NYHA functional class II/III over time was lower in the “extensive” arm (adjusted RR: 0.11; 95% CI: 0.03 to 0.34; p < 0.001), with significant differences at any assessment (except the third month). The differences in E/A recovery and use of antiarrhythmic drugs were less marked, with an RR of 1.55 (95% CI: 0.99 to 2.42; p = 0.05) and RR of 0.76 (95% CI: 0.54 to 1.06; p = 0.11), respectively, with a significantly lower prevalence of antiarrhythmic drugs in the “extensive” ablation arm at 12, 18, and 24 months. Rates of hospitalization for heart failure, overall hospitalization, and the combined event death/hospitalization were lower in the “extensive” arm (p = 0.11, p = 0.003, and p = 0.002, respectively). Conclusions The addition of right-sided ablation improves clinical and electrophysiologic results after maze procedure. |
doi_str_mv | 10.1016/j.jacc.2010.09.055 |
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Background The role of lesion sets on outcome after maze is poorly defined. Methods A total of 141 patients were prospectively followed up. Two different lesion sets were prepared: 32 patients underwent a radiofrequency left atrial lesion set of maze (“limited”), and 109 had combined left and right atrial lesion sets of maze ± ganglionic plexi isolation (“extensive”). A longitudinal observational study assessed the role of “extensive” versus “limited” ablation on atrial fibrillation (AF), New York Heart Association (NYHA) functional class II/III, treatment with antiarrhythmic drugs, follow-up recovery of the ratio of E- to A-wave (E/A), and survival and time to hospitalization (overall and for heart failure). Results The prevalence of AF over time was lower in the “extensive” arm (adjusted relative risk [RR]: 0.10; 95% confidence interval [CI]: 0.03 to 0.31; p < 0.001), with significantly lower prevalence at discharge, 3 months, and 18 months. The prevalence of patients in NYHA functional class II/III over time was lower in the “extensive” arm (adjusted RR: 0.11; 95% CI: 0.03 to 0.34; p < 0.001), with significant differences at any assessment (except the third month). The differences in E/A recovery and use of antiarrhythmic drugs were less marked, with an RR of 1.55 (95% CI: 0.99 to 2.42; p = 0.05) and RR of 0.76 (95% CI: 0.54 to 1.06; p = 0.11), respectively, with a significantly lower prevalence of antiarrhythmic drugs in the “extensive” ablation arm at 12, 18, and 24 months. Rates of hospitalization for heart failure, overall hospitalization, and the combined event death/hospitalization were lower in the “extensive” arm (p = 0.11, p = 0.003, and p = 0.002, respectively). Conclusions The addition of right-sided ablation improves clinical and electrophysiologic results after maze procedure.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2010.09.055</identifier><identifier>PMID: 21329840</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age Distribution ; Aged ; atrial fibrillation ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - mortality ; Atrial Fibrillation - surgery ; Biological and medical sciences ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Catheter Ablation - adverse effects ; Catheter Ablation - methods ; Chronic obstructive pulmonary disease ; Cohort Studies ; Confidence Intervals ; Electrocardiography ; Electrocardiography - methods ; Female ; ganglionic plexi ; Heart ; Hospitalization ; Humans ; Incidence ; Internal Medicine ; Kaplan-Meier Estimate ; Longitudinal Studies ; Male ; maze ; Medical sciences ; Middle Aged ; Odds Ratio ; Perioperative Care - methods ; Postoperative Complications - mortality ; Postoperative Complications - physiopathology ; Prognosis ; Recurrence ; Severity of Illness Index ; Sex Distribution ; Surgery ; surgical ablation ; Survival Rate ; Time Factors ; Treatment Outcome</subject><ispartof>Journal of the American College of Cardiology, 2011-02, Vol.57 (8), p.931-940</ispartof><rights>American College of Cardiology Foundation</rights><rights>2011 American College of Cardiology Foundation</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 22, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-f651f3847ff1337c7d138def04314591b6a8309e5d579e7c31a93e86a35784ab3</citedby><cites>FETCH-LOGICAL-c512t-f651f3847ff1337c7d138def04314591b6a8309e5d579e7c31a93e86a35784ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109710048047$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23939542$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21329840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Onorati, Francesco, MD, PhD</creatorcontrib><creatorcontrib>Mariscalco, Giovanni, MD, PhD</creatorcontrib><creatorcontrib>Rubino, Antonino Salvatore, MD</creatorcontrib><creatorcontrib>Serraino, Filiberto, MD</creatorcontrib><creatorcontrib>Santini, Francesco, MD</creatorcontrib><creatorcontrib>Musazzi, Andrea, MD</creatorcontrib><creatorcontrib>Klersy, Catherine, MD</creatorcontrib><creatorcontrib>Sala, Andrea, MD</creatorcontrib><creatorcontrib>Renzulli, Attilio, MD, PhD</creatorcontrib><title>Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Objectives The objective of this study was to evaluate the effects of different lesion sets of ablation in patients undergoing mitral surgery plus maze. Background The role of lesion sets on outcome after maze is poorly defined. Methods A total of 141 patients were prospectively followed up. Two different lesion sets were prepared: 32 patients underwent a radiofrequency left atrial lesion set of maze (“limited”), and 109 had combined left and right atrial lesion sets of maze ± ganglionic plexi isolation (“extensive”). A longitudinal observational study assessed the role of “extensive” versus “limited” ablation on atrial fibrillation (AF), New York Heart Association (NYHA) functional class II/III, treatment with antiarrhythmic drugs, follow-up recovery of the ratio of E- to A-wave (E/A), and survival and time to hospitalization (overall and for heart failure). Results The prevalence of AF over time was lower in the “extensive” arm (adjusted relative risk [RR]: 0.10; 95% confidence interval [CI]: 0.03 to 0.31; p < 0.001), with significantly lower prevalence at discharge, 3 months, and 18 months. The prevalence of patients in NYHA functional class II/III over time was lower in the “extensive” arm (adjusted RR: 0.11; 95% CI: 0.03 to 0.34; p < 0.001), with significant differences at any assessment (except the third month). The differences in E/A recovery and use of antiarrhythmic drugs were less marked, with an RR of 1.55 (95% CI: 0.99 to 2.42; p = 0.05) and RR of 0.76 (95% CI: 0.54 to 1.06; p = 0.11), respectively, with a significantly lower prevalence of antiarrhythmic drugs in the “extensive” ablation arm at 12, 18, and 24 months. Rates of hospitalization for heart failure, overall hospitalization, and the combined event death/hospitalization were lower in the “extensive” arm (p = 0.11, p = 0.003, and p = 0.002, respectively). Conclusions The addition of right-sided ablation improves clinical and electrophysiologic results after maze procedure.</description><subject>Age Distribution</subject><subject>Aged</subject><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - mortality</subject><subject>Atrial Fibrillation - surgery</subject><subject>Biological and medical sciences</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Catheter Ablation - adverse effects</subject><subject>Catheter Ablation - methods</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Electrocardiography</subject><subject>Electrocardiography - methods</subject><subject>Female</subject><subject>ganglionic plexi</subject><subject>Heart</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Kaplan-Meier Estimate</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>maze</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Perioperative Care - methods</subject><subject>Postoperative Complications - mortality</subject><subject>Postoperative Complications - physiopathology</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Severity of Illness Index</subject><subject>Sex Distribution</subject><subject>Surgery</subject><subject>surgical ablation</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9klGL1DAQgIMo3nr6B3yQgohPXSdN0iQgwnJ458GK4p7PMU0nktpt16QV7t9fyq4e3INPA5NvhpkvQ8hLCmsKtH7XrTvr3LqCnAC9BiEekRUVQpVMaPmYrEAyUVLQ8ow8S6kDgFpR_ZScVZRVWnFYkR_X-4N1UzH6YospjEOxwykVOX4ObXmDcV98wzT3S84Xuzn-DM72xabp7bTQX-PosJ0jFn6MxWaKIb9ehiaG_kg8J0-87RO-OMVz8v3y483Fp3L75er6YrMtnaDVVPpaUM8Ul95TxqSTLWWqRQ-cUS40bWqrGGgUrZAapWPUaoaqtkxIxW3DzsnbY99DHH_PmCazD8lhnmLAcU5GiUpTyjlk8vUDshvnOOThDBVca600rTNVHSkXx5QienOIYW_jraFgFv2mM4t-s-g3oE3Wn4tenVrPzR7bfyV_fWfgzQmwKXv00Q4upHuOaaYFrzL3_shhVvYnYDTJBRyy6hDRTaYdw__n-PCg3PVhWH7uF95iut_XpMqA2S2HstwJBeAKuGR32qC1vQ</recordid><startdate>20110222</startdate><enddate>20110222</enddate><creator>Onorati, Francesco, MD, PhD</creator><creator>Mariscalco, Giovanni, MD, PhD</creator><creator>Rubino, Antonino Salvatore, MD</creator><creator>Serraino, Filiberto, MD</creator><creator>Santini, Francesco, MD</creator><creator>Musazzi, Andrea, MD</creator><creator>Klersy, Catherine, MD</creator><creator>Sala, Andrea, MD</creator><creator>Renzulli, Attilio, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20110222</creationdate><title>Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation</title><author>Onorati, Francesco, MD, PhD ; Mariscalco, Giovanni, MD, PhD ; Rubino, Antonino Salvatore, MD ; Serraino, Filiberto, MD ; Santini, Francesco, MD ; Musazzi, Andrea, MD ; Klersy, Catherine, MD ; Sala, Andrea, MD ; Renzulli, Attilio, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-f651f3847ff1337c7d138def04314591b6a8309e5d579e7c31a93e86a35784ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age Distribution</topic><topic>Aged</topic><topic>atrial fibrillation</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - mortality</topic><topic>Atrial Fibrillation - surgery</topic><topic>Biological and medical sciences</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Catheter Ablation - adverse effects</topic><topic>Catheter Ablation - methods</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Electrocardiography</topic><topic>Electrocardiography - methods</topic><topic>Female</topic><topic>ganglionic plexi</topic><topic>Heart</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Kaplan-Meier Estimate</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>maze</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Perioperative Care - methods</topic><topic>Postoperative Complications - mortality</topic><topic>Postoperative Complications - physiopathology</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Severity of Illness Index</topic><topic>Sex Distribution</topic><topic>Surgery</topic><topic>surgical ablation</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Onorati, Francesco, MD, PhD</creatorcontrib><creatorcontrib>Mariscalco, Giovanni, MD, PhD</creatorcontrib><creatorcontrib>Rubino, Antonino Salvatore, MD</creatorcontrib><creatorcontrib>Serraino, Filiberto, MD</creatorcontrib><creatorcontrib>Santini, Francesco, MD</creatorcontrib><creatorcontrib>Musazzi, Andrea, MD</creatorcontrib><creatorcontrib>Klersy, Catherine, MD</creatorcontrib><creatorcontrib>Sala, Andrea, MD</creatorcontrib><creatorcontrib>Renzulli, Attilio, MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Onorati, Francesco, MD, PhD</au><au>Mariscalco, Giovanni, MD, PhD</au><au>Rubino, Antonino Salvatore, MD</au><au>Serraino, Filiberto, MD</au><au>Santini, Francesco, MD</au><au>Musazzi, Andrea, MD</au><au>Klersy, Catherine, MD</au><au>Sala, Andrea, MD</au><au>Renzulli, Attilio, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2011-02-22</date><risdate>2011</risdate><volume>57</volume><issue>8</issue><spage>931</spage><epage>940</epage><pages>931-940</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Objectives The objective of this study was to evaluate the effects of different lesion sets of ablation in patients undergoing mitral surgery plus maze. Background The role of lesion sets on outcome after maze is poorly defined. Methods A total of 141 patients were prospectively followed up. Two different lesion sets were prepared: 32 patients underwent a radiofrequency left atrial lesion set of maze (“limited”), and 109 had combined left and right atrial lesion sets of maze ± ganglionic plexi isolation (“extensive”). A longitudinal observational study assessed the role of “extensive” versus “limited” ablation on atrial fibrillation (AF), New York Heart Association (NYHA) functional class II/III, treatment with antiarrhythmic drugs, follow-up recovery of the ratio of E- to A-wave (E/A), and survival and time to hospitalization (overall and for heart failure). Results The prevalence of AF over time was lower in the “extensive” arm (adjusted relative risk [RR]: 0.10; 95% confidence interval [CI]: 0.03 to 0.31; p < 0.001), with significantly lower prevalence at discharge, 3 months, and 18 months. The prevalence of patients in NYHA functional class II/III over time was lower in the “extensive” arm (adjusted RR: 0.11; 95% CI: 0.03 to 0.34; p < 0.001), with significant differences at any assessment (except the third month). The differences in E/A recovery and use of antiarrhythmic drugs were less marked, with an RR of 1.55 (95% CI: 0.99 to 2.42; p = 0.05) and RR of 0.76 (95% CI: 0.54 to 1.06; p = 0.11), respectively, with a significantly lower prevalence of antiarrhythmic drugs in the “extensive” ablation arm at 12, 18, and 24 months. Rates of hospitalization for heart failure, overall hospitalization, and the combined event death/hospitalization were lower in the “extensive” arm (p = 0.11, p = 0.003, and p = 0.002, respectively). Conclusions The addition of right-sided ablation improves clinical and electrophysiologic results after maze procedure.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21329840</pmid><doi>10.1016/j.jacc.2010.09.055</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Age Distribution Aged atrial fibrillation Atrial Fibrillation - diagnosis Atrial Fibrillation - mortality Atrial Fibrillation - surgery Biological and medical sciences Cardiac arrhythmia Cardiac dysrhythmias Cardiology Cardiology. Vascular system Cardiovascular Catheter Ablation - adverse effects Catheter Ablation - methods Chronic obstructive pulmonary disease Cohort Studies Confidence Intervals Electrocardiography Electrocardiography - methods Female ganglionic plexi Heart Hospitalization Humans Incidence Internal Medicine Kaplan-Meier Estimate Longitudinal Studies Male maze Medical sciences Middle Aged Odds Ratio Perioperative Care - methods Postoperative Complications - mortality Postoperative Complications - physiopathology Prognosis Recurrence Severity of Illness Index Sex Distribution Surgery surgical ablation Survival Rate Time Factors Treatment Outcome |
title | Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation |
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