Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation

Objectives The objective of this study was to evaluate the effects of different lesion sets of ablation in patients undergoing mitral surgery plus maze. Background The role of lesion sets on outcome after maze is poorly defined. Methods A total of 141 patients were prospectively followed up. Two dif...

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Veröffentlicht in:Journal of the American College of Cardiology 2011-02, Vol.57 (8), p.931-940
Hauptverfasser: Onorati, Francesco, MD, PhD, Mariscalco, Giovanni, MD, PhD, Rubino, Antonino Salvatore, MD, Serraino, Filiberto, MD, Santini, Francesco, MD, Musazzi, Andrea, MD, Klersy, Catherine, MD, Sala, Andrea, MD, Renzulli, Attilio, MD, PhD
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container_end_page 940
container_issue 8
container_start_page 931
container_title Journal of the American College of Cardiology
container_volume 57
creator Onorati, Francesco, MD, PhD
Mariscalco, Giovanni, MD, PhD
Rubino, Antonino Salvatore, MD
Serraino, Filiberto, MD
Santini, Francesco, MD
Musazzi, Andrea, MD
Klersy, Catherine, MD
Sala, Andrea, MD
Renzulli, Attilio, MD, PhD
description Objectives The objective of this study was to evaluate the effects of different lesion sets of ablation in patients undergoing mitral surgery plus maze. Background The role of lesion sets on outcome after maze is poorly defined. Methods A total of 141 patients were prospectively followed up. Two different lesion sets were prepared: 32 patients underwent a radiofrequency left atrial lesion set of maze (“limited”), and 109 had combined left and right atrial lesion sets of maze ± ganglionic plexi isolation (“extensive”). A longitudinal observational study assessed the role of “extensive” versus “limited” ablation on atrial fibrillation (AF), New York Heart Association (NYHA) functional class II/III, treatment with antiarrhythmic drugs, follow-up recovery of the ratio of E- to A-wave (E/A), and survival and time to hospitalization (overall and for heart failure). Results The prevalence of AF over time was lower in the “extensive” arm (adjusted relative risk [RR]: 0.10; 95% confidence interval [CI]: 0.03 to 0.31; p < 0.001), with significantly lower prevalence at discharge, 3 months, and 18 months. The prevalence of patients in NYHA functional class II/III over time was lower in the “extensive” arm (adjusted RR: 0.11; 95% CI: 0.03 to 0.34; p < 0.001), with significant differences at any assessment (except the third month). The differences in E/A recovery and use of antiarrhythmic drugs were less marked, with an RR of 1.55 (95% CI: 0.99 to 2.42; p = 0.05) and RR of 0.76 (95% CI: 0.54 to 1.06; p = 0.11), respectively, with a significantly lower prevalence of antiarrhythmic drugs in the “extensive” ablation arm at 12, 18, and 24 months. Rates of hospitalization for heart failure, overall hospitalization, and the combined event death/hospitalization were lower in the “extensive” arm (p = 0.11, p = 0.003, and p = 0.002, respectively). Conclusions The addition of right-sided ablation improves clinical and electrophysiologic results after maze procedure.
doi_str_mv 10.1016/j.jacc.2010.09.055
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Background The role of lesion sets on outcome after maze is poorly defined. Methods A total of 141 patients were prospectively followed up. Two different lesion sets were prepared: 32 patients underwent a radiofrequency left atrial lesion set of maze (“limited”), and 109 had combined left and right atrial lesion sets of maze ± ganglionic plexi isolation (“extensive”). A longitudinal observational study assessed the role of “extensive” versus “limited” ablation on atrial fibrillation (AF), New York Heart Association (NYHA) functional class II/III, treatment with antiarrhythmic drugs, follow-up recovery of the ratio of E- to A-wave (E/A), and survival and time to hospitalization (overall and for heart failure). Results The prevalence of AF over time was lower in the “extensive” arm (adjusted relative risk [RR]: 0.10; 95% confidence interval [CI]: 0.03 to 0.31; p &lt; 0.001), with significantly lower prevalence at discharge, 3 months, and 18 months. The prevalence of patients in NYHA functional class II/III over time was lower in the “extensive” arm (adjusted RR: 0.11; 95% CI: 0.03 to 0.34; p &lt; 0.001), with significant differences at any assessment (except the third month). The differences in E/A recovery and use of antiarrhythmic drugs were less marked, with an RR of 1.55 (95% CI: 0.99 to 2.42; p = 0.05) and RR of 0.76 (95% CI: 0.54 to 1.06; p = 0.11), respectively, with a significantly lower prevalence of antiarrhythmic drugs in the “extensive” ablation arm at 12, 18, and 24 months. Rates of hospitalization for heart failure, overall hospitalization, and the combined event death/hospitalization were lower in the “extensive” arm (p = 0.11, p = 0.003, and p = 0.002, respectively). Conclusions The addition of right-sided ablation improves clinical and electrophysiologic results after maze procedure.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2010.09.055</identifier><identifier>PMID: 21329840</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age Distribution ; Aged ; atrial fibrillation ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - mortality ; Atrial Fibrillation - surgery ; Biological and medical sciences ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Catheter Ablation - adverse effects ; Catheter Ablation - methods ; Chronic obstructive pulmonary disease ; Cohort Studies ; Confidence Intervals ; Electrocardiography ; Electrocardiography - methods ; Female ; ganglionic plexi ; Heart ; Hospitalization ; Humans ; Incidence ; Internal Medicine ; Kaplan-Meier Estimate ; Longitudinal Studies ; Male ; maze ; Medical sciences ; Middle Aged ; Odds Ratio ; Perioperative Care - methods ; Postoperative Complications - mortality ; Postoperative Complications - physiopathology ; Prognosis ; Recurrence ; Severity of Illness Index ; Sex Distribution ; Surgery ; surgical ablation ; Survival Rate ; Time Factors ; Treatment Outcome</subject><ispartof>Journal of the American College of Cardiology, 2011-02, Vol.57 (8), p.931-940</ispartof><rights>American College of Cardiology Foundation</rights><rights>2011 American College of Cardiology Foundation</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 22, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-f651f3847ff1337c7d138def04314591b6a8309e5d579e7c31a93e86a35784ab3</citedby><cites>FETCH-LOGICAL-c512t-f651f3847ff1337c7d138def04314591b6a8309e5d579e7c31a93e86a35784ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109710048047$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=23939542$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21329840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Onorati, Francesco, MD, PhD</creatorcontrib><creatorcontrib>Mariscalco, Giovanni, MD, PhD</creatorcontrib><creatorcontrib>Rubino, Antonino Salvatore, MD</creatorcontrib><creatorcontrib>Serraino, Filiberto, MD</creatorcontrib><creatorcontrib>Santini, Francesco, MD</creatorcontrib><creatorcontrib>Musazzi, Andrea, MD</creatorcontrib><creatorcontrib>Klersy, Catherine, MD</creatorcontrib><creatorcontrib>Sala, Andrea, MD</creatorcontrib><creatorcontrib>Renzulli, Attilio, MD, PhD</creatorcontrib><title>Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Objectives The objective of this study was to evaluate the effects of different lesion sets of ablation in patients undergoing mitral surgery plus maze. Background The role of lesion sets on outcome after maze is poorly defined. Methods A total of 141 patients were prospectively followed up. Two different lesion sets were prepared: 32 patients underwent a radiofrequency left atrial lesion set of maze (“limited”), and 109 had combined left and right atrial lesion sets of maze ± ganglionic plexi isolation (“extensive”). A longitudinal observational study assessed the role of “extensive” versus “limited” ablation on atrial fibrillation (AF), New York Heart Association (NYHA) functional class II/III, treatment with antiarrhythmic drugs, follow-up recovery of the ratio of E- to A-wave (E/A), and survival and time to hospitalization (overall and for heart failure). Results The prevalence of AF over time was lower in the “extensive” arm (adjusted relative risk [RR]: 0.10; 95% confidence interval [CI]: 0.03 to 0.31; p &lt; 0.001), with significantly lower prevalence at discharge, 3 months, and 18 months. The prevalence of patients in NYHA functional class II/III over time was lower in the “extensive” arm (adjusted RR: 0.11; 95% CI: 0.03 to 0.34; p &lt; 0.001), with significant differences at any assessment (except the third month). The differences in E/A recovery and use of antiarrhythmic drugs were less marked, with an RR of 1.55 (95% CI: 0.99 to 2.42; p = 0.05) and RR of 0.76 (95% CI: 0.54 to 1.06; p = 0.11), respectively, with a significantly lower prevalence of antiarrhythmic drugs in the “extensive” ablation arm at 12, 18, and 24 months. Rates of hospitalization for heart failure, overall hospitalization, and the combined event death/hospitalization were lower in the “extensive” arm (p = 0.11, p = 0.003, and p = 0.002, respectively). Conclusions The addition of right-sided ablation improves clinical and electrophysiologic results after maze procedure.</description><subject>Age Distribution</subject><subject>Aged</subject><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - mortality</subject><subject>Atrial Fibrillation - surgery</subject><subject>Biological and medical sciences</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Catheter Ablation - adverse effects</subject><subject>Catheter Ablation - methods</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Electrocardiography</subject><subject>Electrocardiography - methods</subject><subject>Female</subject><subject>ganglionic plexi</subject><subject>Heart</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Kaplan-Meier Estimate</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>maze</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Perioperative Care - methods</subject><subject>Postoperative Complications - mortality</subject><subject>Postoperative Complications - physiopathology</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Severity of Illness Index</subject><subject>Sex Distribution</subject><subject>Surgery</subject><subject>surgical ablation</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9klGL1DAQgIMo3nr6B3yQgohPXSdN0iQgwnJ458GK4p7PMU0nktpt16QV7t9fyq4e3INPA5NvhpkvQ8hLCmsKtH7XrTvr3LqCnAC9BiEekRUVQpVMaPmYrEAyUVLQ8ow8S6kDgFpR_ZScVZRVWnFYkR_X-4N1UzH6YospjEOxwykVOX4ObXmDcV98wzT3S84Xuzn-DM72xabp7bTQX-PosJ0jFn6MxWaKIb9ehiaG_kg8J0-87RO-OMVz8v3y483Fp3L75er6YrMtnaDVVPpaUM8Ul95TxqSTLWWqRQ-cUS40bWqrGGgUrZAapWPUaoaqtkxIxW3DzsnbY99DHH_PmCazD8lhnmLAcU5GiUpTyjlk8vUDshvnOOThDBVca600rTNVHSkXx5QienOIYW_jraFgFv2mM4t-s-g3oE3Wn4tenVrPzR7bfyV_fWfgzQmwKXv00Q4upHuOaaYFrzL3_shhVvYnYDTJBRyy6hDRTaYdw__n-PCg3PVhWH7uF95iut_XpMqA2S2HstwJBeAKuGR32qC1vQ</recordid><startdate>20110222</startdate><enddate>20110222</enddate><creator>Onorati, Francesco, MD, PhD</creator><creator>Mariscalco, Giovanni, MD, PhD</creator><creator>Rubino, Antonino Salvatore, MD</creator><creator>Serraino, Filiberto, MD</creator><creator>Santini, Francesco, MD</creator><creator>Musazzi, Andrea, MD</creator><creator>Klersy, Catherine, MD</creator><creator>Sala, Andrea, MD</creator><creator>Renzulli, Attilio, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20110222</creationdate><title>Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation</title><author>Onorati, Francesco, MD, PhD ; Mariscalco, Giovanni, MD, PhD ; Rubino, Antonino Salvatore, MD ; Serraino, Filiberto, MD ; Santini, Francesco, MD ; Musazzi, Andrea, MD ; Klersy, Catherine, MD ; Sala, Andrea, MD ; Renzulli, Attilio, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-f651f3847ff1337c7d138def04314591b6a8309e5d579e7c31a93e86a35784ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age Distribution</topic><topic>Aged</topic><topic>atrial fibrillation</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - mortality</topic><topic>Atrial Fibrillation - surgery</topic><topic>Biological and medical sciences</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Catheter Ablation - adverse effects</topic><topic>Catheter Ablation - methods</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Electrocardiography</topic><topic>Electrocardiography - methods</topic><topic>Female</topic><topic>ganglionic plexi</topic><topic>Heart</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Kaplan-Meier Estimate</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>maze</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Perioperative Care - methods</topic><topic>Postoperative Complications - mortality</topic><topic>Postoperative Complications - physiopathology</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Severity of Illness Index</topic><topic>Sex Distribution</topic><topic>Surgery</topic><topic>surgical ablation</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Onorati, Francesco, MD, PhD</creatorcontrib><creatorcontrib>Mariscalco, Giovanni, MD, PhD</creatorcontrib><creatorcontrib>Rubino, Antonino Salvatore, MD</creatorcontrib><creatorcontrib>Serraino, Filiberto, MD</creatorcontrib><creatorcontrib>Santini, Francesco, MD</creatorcontrib><creatorcontrib>Musazzi, Andrea, MD</creatorcontrib><creatorcontrib>Klersy, Catherine, MD</creatorcontrib><creatorcontrib>Sala, Andrea, MD</creatorcontrib><creatorcontrib>Renzulli, Attilio, MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Onorati, Francesco, MD, PhD</au><au>Mariscalco, Giovanni, MD, PhD</au><au>Rubino, Antonino Salvatore, MD</au><au>Serraino, Filiberto, MD</au><au>Santini, Francesco, MD</au><au>Musazzi, Andrea, MD</au><au>Klersy, Catherine, MD</au><au>Sala, Andrea, MD</au><au>Renzulli, Attilio, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2011-02-22</date><risdate>2011</risdate><volume>57</volume><issue>8</issue><spage>931</spage><epage>940</epage><pages>931-940</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Objectives The objective of this study was to evaluate the effects of different lesion sets of ablation in patients undergoing mitral surgery plus maze. Background The role of lesion sets on outcome after maze is poorly defined. Methods A total of 141 patients were prospectively followed up. Two different lesion sets were prepared: 32 patients underwent a radiofrequency left atrial lesion set of maze (“limited”), and 109 had combined left and right atrial lesion sets of maze ± ganglionic plexi isolation (“extensive”). A longitudinal observational study assessed the role of “extensive” versus “limited” ablation on atrial fibrillation (AF), New York Heart Association (NYHA) functional class II/III, treatment with antiarrhythmic drugs, follow-up recovery of the ratio of E- to A-wave (E/A), and survival and time to hospitalization (overall and for heart failure). Results The prevalence of AF over time was lower in the “extensive” arm (adjusted relative risk [RR]: 0.10; 95% confidence interval [CI]: 0.03 to 0.31; p &lt; 0.001), with significantly lower prevalence at discharge, 3 months, and 18 months. The prevalence of patients in NYHA functional class II/III over time was lower in the “extensive” arm (adjusted RR: 0.11; 95% CI: 0.03 to 0.34; p &lt; 0.001), with significant differences at any assessment (except the third month). The differences in E/A recovery and use of antiarrhythmic drugs were less marked, with an RR of 1.55 (95% CI: 0.99 to 2.42; p = 0.05) and RR of 0.76 (95% CI: 0.54 to 1.06; p = 0.11), respectively, with a significantly lower prevalence of antiarrhythmic drugs in the “extensive” ablation arm at 12, 18, and 24 months. Rates of hospitalization for heart failure, overall hospitalization, and the combined event death/hospitalization were lower in the “extensive” arm (p = 0.11, p = 0.003, and p = 0.002, respectively). Conclusions The addition of right-sided ablation improves clinical and electrophysiologic results after maze procedure.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21329840</pmid><doi>10.1016/j.jacc.2010.09.055</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Age Distribution
Aged
atrial fibrillation
Atrial Fibrillation - diagnosis
Atrial Fibrillation - mortality
Atrial Fibrillation - surgery
Biological and medical sciences
Cardiac arrhythmia
Cardiac dysrhythmias
Cardiology
Cardiology. Vascular system
Cardiovascular
Catheter Ablation - adverse effects
Catheter Ablation - methods
Chronic obstructive pulmonary disease
Cohort Studies
Confidence Intervals
Electrocardiography
Electrocardiography - methods
Female
ganglionic plexi
Heart
Hospitalization
Humans
Incidence
Internal Medicine
Kaplan-Meier Estimate
Longitudinal Studies
Male
maze
Medical sciences
Middle Aged
Odds Ratio
Perioperative Care - methods
Postoperative Complications - mortality
Postoperative Complications - physiopathology
Prognosis
Recurrence
Severity of Illness Index
Sex Distribution
Surgery
surgical ablation
Survival Rate
Time Factors
Treatment Outcome
title Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation
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