Cyclosporine for SJS/TEN: A Case Series and Review of the Literature
Clear guidelines for the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are lacking due to its infrequency and the absence of large controlled studies. Systemic corticosteroids and intravenous immunoglobulin (IVIG) have received considerable attention, though report...
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| Veröffentlicht in: | Cutis (New York, N.Y.) N.Y.), 2011, Vol.87 (1), p.24-29 |
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| container_title | Cutis (New York, N.Y.) |
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| creator | REESE, Drew HENNING, J. Scott ROCKERS, Kyle LADD, Denise GILSON, Robert |
| description | Clear guidelines for the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are lacking due to its infrequency and the absence of large controlled studies. Systemic corticosteroids and intravenous immunoglobulin (IVIG) have received considerable attention, though reports of the use of these agents have demonstrated mixed success rates in improving morbidity and mortality from SJS/TEN. We present a case series of 4 patients with SJS/TEN who rapidly responded to treatment with cyclosporin A (CsA). We discuss the proposed mechanism of action and the rationale for the use of cyclosporin based on the currently understood pathophysiologic mechanism of TEN. |
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| ispartof | Cutis (New York, N.Y.), 2011, Vol.87 (1), p.24-29 |
| issn | 0011-4162 2326-6929 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Acetaminophen - adverse effects Adult Analgesics, Non-Narcotic - adverse effects Anti-Infective Agents - adverse effects Anticonvulsants - adverse effects Biological and medical sciences Cyclosporine - therapeutic use Dermatologic Agents - therapeutic use Dermatology Drug Combinations Female Humans Male Medical sciences Stevens-Johnson Syndrome - chemically induced Stevens-Johnson Syndrome - drug therapy Sulfamethizole - adverse effects Triazines - adverse effects Trimethoprim - adverse effects |
| title | Cyclosporine for SJS/TEN: A Case Series and Review of the Literature |
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