The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties

Some antibiotics, including minocycline, have recently been reported to display immunomodulatory properties in addition to their antimicrobial activity. The use of a compound with both immunomodulatory and antibacterial properties could be very interesting in the treatment of inflammatory bowel dise...

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Veröffentlicht in:	Pharmacological research 2011-04, Vol.63 (4), p.308-319
Hauptverfasser:	Garrido-Mesa, Natividad, Camuesco, Desirée, Arribas, Belén, Comalada, Mònica, Bailón, Elvira, Cueto-Sola, Margarita, Utrilla, Pilar, Nieto, Ana, Zarzuelo, Antonio, Rodríguez-Cabezas, María Elena, Gálvez, Julio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antibiotics Antimicrobial activity Antimicrobial agents Caco-2 Cells Cell Line Colitis Colitis - chemically induced Colitis - drug therapy Colitis - pathology Dextran Dextran Sulfate Epithelial cells Experimental colitis Female Humans Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Immunomodulation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - drug therapy Interleukin 8 Intestine Macrophages Macrophages - drug effects Metronidazole Mice Mice, Inbred C57BL Minocycline Minocycline - pharmacology Minocycline - therapeutic use Nitrite Rats Rats, Wistar RAW 264.7 cells sodium sulfate Tetracycline Tetracyclines Trinitrobenzenesulfonic Acid
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