Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: A new genetically tractable model for human cancer associated fibroblasts

We have recently proposed a new model for understanding tumor metabolism, termed: "The Autophagic Tumor Stroma Model of Cancer Metabolism". In this new paradigm, catabolism (autophagy) in the tumor stroma fuels the anabolic growth of aggressive cancer cells. Mechanistically, tumor cells in...

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Veröffentlicht in:	Cancer biology & therapy 2011-02, Vol.11 (4), p.383-394
Hauptverfasser:	Trimmer, Casey, Sotgia, Federica, Whitaker-Menezes, Diana, Balliet, Renee M., Eaton, Gregory, Martinez-Outschoorn, Ubaldo E., Pavlides, Stephanos, Howell, Anthony, Iozzo, Renato V., Pestell, Richard G., Scherer, Philipp E., Capozza, Franco, Lisanti, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Biology Bioscience Calcium Cancer Caveolin 1 - genetics Caveolin 1 - metabolism Caveolin 1 - pharmacology Cell Cell Line, Transformed Cell Line, Tumor Cell Proliferation - drug effects Cycle Female Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Regulation, Neoplastic - genetics Gene Knockdown Techniques Humans Landes Mice Mice, Nude Mitochondria - enzymology Mitochondria - metabolism Models, Biological Neoplasms - genetics Neoplasms - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Organogenesis Oxidative Stress - drug effects Oxidative Stress - genetics Proteins Proteomics Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Research Paper RNA, Small Interfering Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase - pharmacology Tumor Microenvironment - drug effects Tumor Microenvironment - genetics Xenograft Model Antitumor Assays
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