Predicted expansion of the claudin multigene family
Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the paracellular permselective barrier. They are produced by a multi-gene family of 24 reported members in mouse and human. Based on a comprehensive search combined with phylogenetic analyses, we identified three no...
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| Veröffentlicht in: | FEBS letters 2011-02, Vol.585 (4), p.606-612 |
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| creator | Mineta, Katsuhiko Yamamoto, Yasuko Yamazaki, Yuji Tanaka, Hiroo Tada, Yukiyo Saito, Kuniaki Tamura, Atsushi Igarashi, Michihiro Endo, Toshinori Takeuchi, Kosei Tsukita, Sachiko |
| description | Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the paracellular permselective barrier. They are produced by a multi-gene family of 24 reported members in mouse and human. Based on a comprehensive search combined with phylogenetic analyses, we identified three novel claudins (claudin-25, -26, and -27). Quantitative RT-PCR revealed that the three novel claudins were expressed in a tissue- and/or developmental stage-dependent manner. Claudins-25 and -26, but not claudin-27, were immunofluorescently localized to TJs when exogenously expressed in cultured MDCK and Eph epithelial cell lines. These findings expand the claudin family to include at least 27 members.
Claudin-25
and
ZO-1
colocalize by
fluorescence microscopy
(View interaction)
ZO-1
and
Claudin-26
colocalize by
fluorescence microscopy
(View interaction) |
| doi_str_mv | 10.1016/j.febslet.2011.01.028 |
| format | Article |
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Claudin-25
and
ZO-1
colocalize by
fluorescence microscopy
(View interaction)
ZO-1
and
Claudin-26
colocalize by
fluorescence microscopy
(View interaction)</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2011.01.028</identifier><identifier>PMID: 21276448</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>adherens junction ; Amino Acid Sequence ; Animals ; Cell adhesion ; Cell Line ; Claudin ; Claudins - chemistry ; Claudins - genetics ; Claudins - metabolism ; Cldn ; Conserved Sequence ; Databases, Protein ; Dogs ; Epithelial cells ; Epithelial Cells - metabolism ; Epithelial Cells - ultrastructure ; Gene Expression Regulation, Developmental ; Gene Library ; Humans ; Mice ; Organ Specificity ; Paracellular barrier ; Phylogeny ; Protein Isoforms - chemistry ; Protein Isoforms - genetics ; Protein Isoforms - metabolism ; Protein Structure, Secondary ; PSI-BLAST ; Recombinant Proteins ; RNA, Messenger - metabolism ; Sequence Alignment ; Tight junction ; Tight Junctions - metabolism</subject><ispartof>FEBS letters, 2011-02, Vol.585 (4), p.606-612</ispartof><rights>2011 Federation of European Biochemical Societies</rights><rights>FEBS Letters 585 (2011) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5805-91b1461442b1908a7d560d6d1ccc34e89c8ee384e903618881e5ca634d3ba9013</citedby><cites>FETCH-LOGICAL-c5805-91b1461442b1908a7d560d6d1ccc34e89c8ee384e903618881e5ca634d3ba9013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2011.01.028$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579311000585$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3536,27903,27904,45553,45554,46387,46811,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21276448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mineta, Katsuhiko</creatorcontrib><creatorcontrib>Yamamoto, Yasuko</creatorcontrib><creatorcontrib>Yamazaki, Yuji</creatorcontrib><creatorcontrib>Tanaka, Hiroo</creatorcontrib><creatorcontrib>Tada, Yukiyo</creatorcontrib><creatorcontrib>Saito, Kuniaki</creatorcontrib><creatorcontrib>Tamura, Atsushi</creatorcontrib><creatorcontrib>Igarashi, Michihiro</creatorcontrib><creatorcontrib>Endo, Toshinori</creatorcontrib><creatorcontrib>Takeuchi, Kosei</creatorcontrib><creatorcontrib>Tsukita, Sachiko</creatorcontrib><title>Predicted expansion of the claudin multigene family</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the paracellular permselective barrier. They are produced by a multi-gene family of 24 reported members in mouse and human. Based on a comprehensive search combined with phylogenetic analyses, we identified three novel claudins (claudin-25, -26, and -27). Quantitative RT-PCR revealed that the three novel claudins were expressed in a tissue- and/or developmental stage-dependent manner. Claudins-25 and -26, but not claudin-27, were immunofluorescently localized to TJs when exogenously expressed in cultured MDCK and Eph epithelial cell lines. These findings expand the claudin family to include at least 27 members.
Claudin-25
and
ZO-1
colocalize by
fluorescence microscopy
(View interaction)
ZO-1
and
Claudin-26
colocalize by
fluorescence microscopy
(View interaction)</description><subject>adherens junction</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Cell adhesion</subject><subject>Cell Line</subject><subject>Claudin</subject><subject>Claudins - chemistry</subject><subject>Claudins - genetics</subject><subject>Claudins - metabolism</subject><subject>Cldn</subject><subject>Conserved Sequence</subject><subject>Databases, Protein</subject><subject>Dogs</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelial Cells - ultrastructure</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Library</subject><subject>Humans</subject><subject>Mice</subject><subject>Organ Specificity</subject><subject>Paracellular barrier</subject><subject>Phylogeny</subject><subject>Protein Isoforms - chemistry</subject><subject>Protein Isoforms - genetics</subject><subject>Protein Isoforms - metabolism</subject><subject>Protein Structure, Secondary</subject><subject>PSI-BLAST</subject><subject>Recombinant Proteins</subject><subject>RNA, Messenger - metabolism</subject><subject>Sequence Alignment</subject><subject>Tight junction</subject><subject>Tight Junctions - metabolism</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVtP3DAQhS1UBNuFnwDKW3nJ4okvsZ8QRVwqIYEEPFuOPWm9ymUbJ5T99_VqtzwWpBmNLH1zxjqHkBOgC6Agz5eLGqvY4LgoKMCCpirUHpmBKlnOuFRfyIxS4LkoNTskX2Nc0vRWoA_IYQFFKTlXM8IeB_TBjegzfFvZLoa-y_o6G39h5ho7-dBl7dSM4Sd2mNW2Dc36iOzXtol4vJtz8nJz_Xx1l98_3P64urzPnVBU5Boq4BI4LyrQVNnSC0m99OCcYxyVdgqRKY6aMglKKUDhrGTcs8pqCmxOvm11V0P_e8I4mjZEh01jO-ynaJQAzXipy0Se_ZdMjpVaMpF6TsQWdUMf44C1WQ2htcM6QRtOmqXZOWs2zhqaqlBp73R3Yqpa9O9b_6xMwN0W-BMaXH9O1dxcfy-eNjFtUgJICQklktTFVgqTu68BBxNdwM6lpAZ0o_F9-OC3fwHfQ5-u</recordid><startdate>20110218</startdate><enddate>20110218</enddate><creator>Mineta, Katsuhiko</creator><creator>Yamamoto, Yasuko</creator><creator>Yamazaki, Yuji</creator><creator>Tanaka, Hiroo</creator><creator>Tada, Yukiyo</creator><creator>Saito, Kuniaki</creator><creator>Tamura, Atsushi</creator><creator>Igarashi, Michihiro</creator><creator>Endo, Toshinori</creator><creator>Takeuchi, Kosei</creator><creator>Tsukita, Sachiko</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110218</creationdate><title>Predicted expansion of the claudin multigene family</title><author>Mineta, Katsuhiko ; Yamamoto, Yasuko ; Yamazaki, Yuji ; Tanaka, Hiroo ; Tada, Yukiyo ; Saito, Kuniaki ; Tamura, Atsushi ; Igarashi, Michihiro ; Endo, Toshinori ; Takeuchi, Kosei ; Tsukita, Sachiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5805-91b1461442b1908a7d560d6d1ccc34e89c8ee384e903618881e5ca634d3ba9013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>adherens junction</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Cell adhesion</topic><topic>Cell Line</topic><topic>Claudin</topic><topic>Claudins - chemistry</topic><topic>Claudins - genetics</topic><topic>Claudins - metabolism</topic><topic>Cldn</topic><topic>Conserved Sequence</topic><topic>Databases, Protein</topic><topic>Dogs</topic><topic>Epithelial cells</topic><topic>Epithelial Cells - metabolism</topic><topic>Epithelial Cells - ultrastructure</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene Library</topic><topic>Humans</topic><topic>Mice</topic><topic>Organ Specificity</topic><topic>Paracellular barrier</topic><topic>Phylogeny</topic><topic>Protein Isoforms - chemistry</topic><topic>Protein Isoforms - genetics</topic><topic>Protein Isoforms - metabolism</topic><topic>Protein Structure, Secondary</topic><topic>PSI-BLAST</topic><topic>Recombinant Proteins</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Alignment</topic><topic>Tight junction</topic><topic>Tight Junctions - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mineta, Katsuhiko</creatorcontrib><creatorcontrib>Yamamoto, Yasuko</creatorcontrib><creatorcontrib>Yamazaki, Yuji</creatorcontrib><creatorcontrib>Tanaka, Hiroo</creatorcontrib><creatorcontrib>Tada, Yukiyo</creatorcontrib><creatorcontrib>Saito, Kuniaki</creatorcontrib><creatorcontrib>Tamura, Atsushi</creatorcontrib><creatorcontrib>Igarashi, Michihiro</creatorcontrib><creatorcontrib>Endo, Toshinori</creatorcontrib><creatorcontrib>Takeuchi, Kosei</creatorcontrib><creatorcontrib>Tsukita, Sachiko</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mineta, Katsuhiko</au><au>Yamamoto, Yasuko</au><au>Yamazaki, Yuji</au><au>Tanaka, Hiroo</au><au>Tada, Yukiyo</au><au>Saito, Kuniaki</au><au>Tamura, Atsushi</au><au>Igarashi, Michihiro</au><au>Endo, Toshinori</au><au>Takeuchi, Kosei</au><au>Tsukita, Sachiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicted expansion of the claudin multigene family</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2011-02-18</date><risdate>2011</risdate><volume>585</volume><issue>4</issue><spage>606</spage><epage>612</epage><pages>606-612</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the paracellular permselective barrier. They are produced by a multi-gene family of 24 reported members in mouse and human. Based on a comprehensive search combined with phylogenetic analyses, we identified three novel claudins (claudin-25, -26, and -27). Quantitative RT-PCR revealed that the three novel claudins were expressed in a tissue- and/or developmental stage-dependent manner. Claudins-25 and -26, but not claudin-27, were immunofluorescently localized to TJs when exogenously expressed in cultured MDCK and Eph epithelial cell lines. These findings expand the claudin family to include at least 27 members.
Claudin-25
and
ZO-1
colocalize by
fluorescence microscopy
(View interaction)
ZO-1
and
Claudin-26
colocalize by
fluorescence microscopy
(View interaction)</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>21276448</pmid><doi>10.1016/j.febslet.2011.01.028</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 2011-02, Vol.585 (4), p.606-612 |
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| source | MEDLINE; Wiley Online Library; Wiley Online Library Journals; Elsevier ScienceDirect Journals; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | adherens junction Amino Acid Sequence Animals Cell adhesion Cell Line Claudin Claudins - chemistry Claudins - genetics Claudins - metabolism Cldn Conserved Sequence Databases, Protein Dogs Epithelial cells Epithelial Cells - metabolism Epithelial Cells - ultrastructure Gene Expression Regulation, Developmental Gene Library Humans Mice Organ Specificity Paracellular barrier Phylogeny Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Structure, Secondary PSI-BLAST Recombinant Proteins RNA, Messenger - metabolism Sequence Alignment Tight junction Tight Junctions - metabolism |
| title | Predicted expansion of the claudin multigene family |
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