Influence of Gestational Age on Fibrinolysis from Birth to Postnatal Day 10
Objective To compare components of the fibrinolytic cascade in newborns of gestational age ranging from extreme prematurity to full term, at birth and for the next 10 days, and in their mothers at delivery. Study design We studied 10 extremely preterm neonates, 10 very preterm neonates, 10 moderatel...
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| Veröffentlicht in: | The Journal of pediatrics 2011-03, Vol.158 (3), p.377-382.e1 |
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| container_end_page | 382.e1 |
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| container_title | The Journal of pediatrics |
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| creator | Sentilhes, Loïc, MD, PhD Leroux, Philippe, PhD Radi, Sophie, MD Ricbourg-Schneider, Aude, MD Laudenbach, Vincent, MD, PhD Marpeau, Loïc, MD, PhD Bénichou, Jacques, MD, PhD Vasse, Marc, PhD Marret, Stéphane, MD, PhD |
| description | Objective To compare components of the fibrinolytic cascade in newborns of gestational age ranging from extreme prematurity to full term, at birth and for the next 10 days, and in their mothers at delivery. Study design We studied 10 extremely preterm neonates, 10 very preterm neonates, 10 moderately preterm neonates, 10 full-term neonates, and their mothers (n = 40). We measured the antigen levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitors 1 (PAI-1) and 2 (PAI-2), and thrombin-activatable fibrinolysis inhibitor, as well as PAI-1 activity, in neonates at birth and on postnatal days 3 and 10 and in mothers at delivery. Results On day 10, both PAI-1 antigen and activity were higher in extremely preterm neonates than in full-term neonates ( P = .004 and |
| doi_str_mv | 10.1016/j.jpeds.2010.08.033 |
| format | Article |
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Study design We studied 10 extremely preterm neonates, 10 very preterm neonates, 10 moderately preterm neonates, 10 full-term neonates, and their mothers (n = 40). We measured the antigen levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitors 1 (PAI-1) and 2 (PAI-2), and thrombin-activatable fibrinolysis inhibitor, as well as PAI-1 activity, in neonates at birth and on postnatal days 3 and 10 and in mothers at delivery. Results On day 10, both PAI-1 antigen and activity were higher in extremely preterm neonates than in full-term neonates ( P = .004 and <.0006, respectively), and the t-PA/PAI-1 activity ratio was lower in the extremely preterm and very preterm neonates compared with the full-term neonates ( P = .002 and .017, respectively). No significant differences in the fibrinolytic system components were seen among the 4 groups of mothers. Conclusions The development of fibrinolysis suppression in extremely preterm infants within 10 days after birth may contribute to the increased risk of periventricular hemorrhagic infarction in these infants.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2010.08.033</identifier><identifier>PMID: 20889163</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>Maryland Heights, MO: Mosby, Inc</publisher><subject>antigens ; Biological and medical sciences ; Biomarkers ; Carboxypeptidase B2 - blood ; fibrinolysis ; Fibrinolysis - physiology ; General aspects ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; infarction ; Medical sciences ; mothers ; neonates ; Pediatrics ; plasminogen activator ; Plasminogen Activator Inhibitor 1 - blood ; Plasminogen Activator Inhibitor 2 - blood ; premature birth ; risk ; Tissue Plasminogen Activator - blood</subject><ispartof>The Journal of pediatrics, 2011-03, Vol.158 (3), p.377-382.e1</ispartof><rights>Mosby, Inc.</rights><rights>2011 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-8448f25aaf7d91409952a7563b9d85dcffd1cb222d17db0f1d003f4e90db3ff83</citedby><cites>FETCH-LOGICAL-c467t-8448f25aaf7d91409952a7563b9d85dcffd1cb222d17db0f1d003f4e90db3ff83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2010.08.033$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23919980$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20889163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sentilhes, Loïc, MD, PhD</creatorcontrib><creatorcontrib>Leroux, Philippe, PhD</creatorcontrib><creatorcontrib>Radi, Sophie, MD</creatorcontrib><creatorcontrib>Ricbourg-Schneider, Aude, MD</creatorcontrib><creatorcontrib>Laudenbach, Vincent, MD, PhD</creatorcontrib><creatorcontrib>Marpeau, Loïc, MD, PhD</creatorcontrib><creatorcontrib>Bénichou, Jacques, MD, PhD</creatorcontrib><creatorcontrib>Vasse, Marc, PhD</creatorcontrib><creatorcontrib>Marret, Stéphane, MD, PhD</creatorcontrib><title>Influence of Gestational Age on Fibrinolysis from Birth to Postnatal Day 10</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective To compare components of the fibrinolytic cascade in newborns of gestational age ranging from extreme prematurity to full term, at birth and for the next 10 days, and in their mothers at delivery. Study design We studied 10 extremely preterm neonates, 10 very preterm neonates, 10 moderately preterm neonates, 10 full-term neonates, and their mothers (n = 40). We measured the antigen levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitors 1 (PAI-1) and 2 (PAI-2), and thrombin-activatable fibrinolysis inhibitor, as well as PAI-1 activity, in neonates at birth and on postnatal days 3 and 10 and in mothers at delivery. Results On day 10, both PAI-1 antigen and activity were higher in extremely preterm neonates than in full-term neonates ( P = .004 and <.0006, respectively), and the t-PA/PAI-1 activity ratio was lower in the extremely preterm and very preterm neonates compared with the full-term neonates ( P = .002 and .017, respectively). No significant differences in the fibrinolytic system components were seen among the 4 groups of mothers. Conclusions The development of fibrinolysis suppression in extremely preterm infants within 10 days after birth may contribute to the increased risk of periventricular hemorrhagic infarction in these infants.</description><subject>antigens</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Carboxypeptidase B2 - blood</subject><subject>fibrinolysis</subject><subject>Fibrinolysis - physiology</subject><subject>General aspects</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>infarction</subject><subject>Medical sciences</subject><subject>mothers</subject><subject>neonates</subject><subject>Pediatrics</subject><subject>plasminogen activator</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Plasminogen Activator Inhibitor 2 - blood</subject><subject>premature birth</subject><subject>risk</subject><subject>Tissue Plasminogen Activator - blood</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl9rFDEUxYModq1-AkHnpfg025tkMkkeFNpqa7GgUPscMvlTM85O1mRG2G9vxl0VfOlT4PI7N4dzLkIvMawx4Pa0X_dbZ_OaQJmAWAOlj9AKg-R1Kyh9jFYAhNS04e0RepZzDwCyAXiKjggIIXFLV-jT9eiH2Y3GVdFXVy5Pegpx1EN1dl9GY3UZuhTGOOxyyJVPcVOdhzR9q6ZYfYl5GvVU2Pd6V2F4jp54PWT34vAeo7vLD18vPtY3n6-uL85uatO0fKpF0whPmNaeW4kbkJIRzVlLO2kFs8Z7i01HCLGY2w48tgDUN06C7aj3gh6jN_u92xR_zMWy2oRs3DDo0cU5K8EwZ4RCU0i6J02KOSfn1TaFjU47hUEtIape_Q5RLSEqEKqEWFSvDvvnbuPsX82f1ApwcgB0NnrwSY8m5H8clVhKAYV7vee8jkrfp8Lc3ZafWGlCcMwWg2_3hCt5_QwuqWzC0oYNyZlJ2RgesPruP70ZwhiKqe9u53If51S6zAqrTBSo2-UiloPAxQEnDOgvAfutcw</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Sentilhes, Loïc, MD, PhD</creator><creator>Leroux, Philippe, PhD</creator><creator>Radi, Sophie, MD</creator><creator>Ricbourg-Schneider, Aude, MD</creator><creator>Laudenbach, Vincent, MD, PhD</creator><creator>Marpeau, Loïc, MD, PhD</creator><creator>Bénichou, Jacques, MD, PhD</creator><creator>Vasse, Marc, PhD</creator><creator>Marret, Stéphane, MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110301</creationdate><title>Influence of Gestational Age on Fibrinolysis from Birth to Postnatal Day 10</title><author>Sentilhes, Loïc, MD, PhD ; Leroux, Philippe, PhD ; Radi, Sophie, MD ; Ricbourg-Schneider, Aude, MD ; Laudenbach, Vincent, MD, PhD ; Marpeau, Loïc, MD, PhD ; Bénichou, Jacques, MD, PhD ; Vasse, Marc, PhD ; Marret, Stéphane, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-8448f25aaf7d91409952a7563b9d85dcffd1cb222d17db0f1d003f4e90db3ff83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>antigens</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Carboxypeptidase B2 - blood</topic><topic>fibrinolysis</topic><topic>Fibrinolysis - physiology</topic><topic>General aspects</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>infarction</topic><topic>Medical sciences</topic><topic>mothers</topic><topic>neonates</topic><topic>Pediatrics</topic><topic>plasminogen activator</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Plasminogen Activator Inhibitor 2 - blood</topic><topic>premature birth</topic><topic>risk</topic><topic>Tissue Plasminogen Activator - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sentilhes, Loïc, MD, PhD</creatorcontrib><creatorcontrib>Leroux, Philippe, PhD</creatorcontrib><creatorcontrib>Radi, Sophie, MD</creatorcontrib><creatorcontrib>Ricbourg-Schneider, Aude, MD</creatorcontrib><creatorcontrib>Laudenbach, Vincent, MD, PhD</creatorcontrib><creatorcontrib>Marpeau, Loïc, MD, PhD</creatorcontrib><creatorcontrib>Bénichou, Jacques, MD, PhD</creatorcontrib><creatorcontrib>Vasse, Marc, PhD</creatorcontrib><creatorcontrib>Marret, Stéphane, MD, PhD</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sentilhes, Loïc, MD, PhD</au><au>Leroux, Philippe, PhD</au><au>Radi, Sophie, MD</au><au>Ricbourg-Schneider, Aude, MD</au><au>Laudenbach, Vincent, MD, PhD</au><au>Marpeau, Loïc, MD, PhD</au><au>Bénichou, Jacques, MD, PhD</au><au>Vasse, Marc, PhD</au><au>Marret, Stéphane, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Gestational Age on Fibrinolysis from Birth to Postnatal Day 10</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>158</volume><issue>3</issue><spage>377</spage><epage>382.e1</epage><pages>377-382.e1</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objective To compare components of the fibrinolytic cascade in newborns of gestational age ranging from extreme prematurity to full term, at birth and for the next 10 days, and in their mothers at delivery. Study design We studied 10 extremely preterm neonates, 10 very preterm neonates, 10 moderately preterm neonates, 10 full-term neonates, and their mothers (n = 40). We measured the antigen levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitors 1 (PAI-1) and 2 (PAI-2), and thrombin-activatable fibrinolysis inhibitor, as well as PAI-1 activity, in neonates at birth and on postnatal days 3 and 10 and in mothers at delivery. Results On day 10, both PAI-1 antigen and activity were higher in extremely preterm neonates than in full-term neonates ( P = .004 and <.0006, respectively), and the t-PA/PAI-1 activity ratio was lower in the extremely preterm and very preterm neonates compared with the full-term neonates ( P = .002 and .017, respectively). No significant differences in the fibrinolytic system components were seen among the 4 groups of mothers. Conclusions The development of fibrinolysis suppression in extremely preterm infants within 10 days after birth may contribute to the increased risk of periventricular hemorrhagic infarction in these infants.</abstract><cop>Maryland Heights, MO</cop><pub>Mosby, Inc</pub><pmid>20889163</pmid><doi>10.1016/j.jpeds.2010.08.033</doi><tpages>6</tpages></addata></record> |
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| subjects | antigens Biological and medical sciences Biomarkers Carboxypeptidase B2 - blood fibrinolysis Fibrinolysis - physiology General aspects Gestational Age Humans Infant, Newborn Infant, Premature infarction Medical sciences mothers neonates Pediatrics plasminogen activator Plasminogen Activator Inhibitor 1 - blood Plasminogen Activator Inhibitor 2 - blood premature birth risk Tissue Plasminogen Activator - blood |
| title | Influence of Gestational Age on Fibrinolysis from Birth to Postnatal Day 10 |
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