Chronic kidney disease elicits excessive increase in left ventricular mass growth in patients at increased risk for cardiovascular events
BACKGROUNDThe hemodynamic alterations induced by the impairment of renal function explain only in part the development of left ventricular hypertrophy in patients with chronic kidney disease (CKD), who are theoretically exposed to an inappropriate high growth of left ventricular mass (iLVM) due to t...
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| Veröffentlicht in: | Journal of hypertension 2011-03, Vol.29 (3), p.565-573 |
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| container_title | Journal of hypertension |
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| creator | Cioffi, Giovanni Tarantini, Luigi Frizzi, Roberto Stefenelli, Carlo Russo, Tiziano E Selmi, Alessandro Toller, Chiara Furlanello, Francesco de Simone, Giovanni |
| description | BACKGROUNDThe hemodynamic alterations induced by the impairment of renal function explain only in part the development of left ventricular hypertrophy in patients with chronic kidney disease (CKD), who are theoretically exposed to an inappropriate high growth of left ventricular mass (iLVM) due to the activation of neuro-hormonal stressors. Few data are available on the relations between iLVM and renal function.
STUDY DESIGN AND MEASUREMENTSThree hundred and forty individuals at increased risk for cardiovascular events underwent assessment of renal function by the estimation of glomerular filtration rate (eGFR) and echocardiography227 patients had stages 1–2 CKD (eGFR ≥60 ml/min per 1.73 m), and 113 stages 3–5 (eGFR |
| doi_str_mv | 10.1097/HJH.0b013e3283424188 |
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STUDY DESIGN AND MEASUREMENTSThree hundred and forty individuals at increased risk for cardiovascular events underwent assessment of renal function by the estimation of glomerular filtration rate (eGFR) and echocardiography227 patients had stages 1–2 CKD (eGFR ≥60 ml/min per 1.73 m), and 113 stages 3–5 (eGFR <60 ml/min per 1.73 m). LVM was predicted in each patient from height, sex and stroke work using a validated equation. iLVM was defined as LVM more than 28% of the predicted value. Sixty-eight healthy individuals served as controls.
RESULTSiLVM was detected in seven controls (10%) and in 146 study patients (43%). There was an inverse relation between observed/predicted LVM ratio and eGFR (r 0.54, P < 0.001). In linear regression analysis, iLVM was related to eGFR (β 0.40), relative wall thickness (β 0.29), diabetes (β 0.14), and maximal left atrial volume (β 0.25) (all P < 0.001). Prevalence of iLVM was 10% in patients in stage-1 CKD, 31% in stage 2, 67% in stage 3, and 100% in stages 4 and 5.
CONCLUSIONIn patients at increased risk for cardiovascular events, iLVM is strongly related to the presence and magnitude of CKD. Further longitudinal studies are needed to evaluate the prognostic value of the coexistence of iLVM and CKD.</description><identifier>ISSN: 0263-6352</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/HJH.0b013e3283424188</identifier><identifier>PMID: 21150636</identifier><identifier>CODEN: JOHYD3</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Aged ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - etiology ; Chronic Disease ; Diabetes Mellitus - pathology ; Experimental diseases ; Female ; Humans ; Hypertrophy, Left Ventricular - epidemiology ; Hypertrophy, Left Ventricular - etiology ; Hypertrophy, Left Ventricular - pathology ; Kidney Diseases - complications ; Linear Models ; Male ; Medical sciences ; Middle Aged ; Prevalence ; Risk ; Ventricular Function, Left</subject><ispartof>Journal of hypertension, 2011-03, Vol.29 (3), p.565-573</ispartof><rights>2011 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3858-2b50e3f91a2fa44b315c261b78993c3ce086ff77f6464c2fc3482e133cf1eb283</citedby><cites>FETCH-LOGICAL-c3858-2b50e3f91a2fa44b315c261b78993c3ce086ff77f6464c2fc3482e133cf1eb283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23896705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21150636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cioffi, Giovanni</creatorcontrib><creatorcontrib>Tarantini, Luigi</creatorcontrib><creatorcontrib>Frizzi, Roberto</creatorcontrib><creatorcontrib>Stefenelli, Carlo</creatorcontrib><creatorcontrib>Russo, Tiziano E</creatorcontrib><creatorcontrib>Selmi, Alessandro</creatorcontrib><creatorcontrib>Toller, Chiara</creatorcontrib><creatorcontrib>Furlanello, Francesco</creatorcontrib><creatorcontrib>de Simone, Giovanni</creatorcontrib><title>Chronic kidney disease elicits excessive increase in left ventricular mass growth in patients at increased risk for cardiovascular events</title><title>Journal of hypertension</title><addtitle>J Hypertens</addtitle><description>BACKGROUNDThe hemodynamic alterations induced by the impairment of renal function explain only in part the development of left ventricular hypertrophy in patients with chronic kidney disease (CKD), who are theoretically exposed to an inappropriate high growth of left ventricular mass (iLVM) due to the activation of neuro-hormonal stressors. Few data are available on the relations between iLVM and renal function.
STUDY DESIGN AND MEASUREMENTSThree hundred and forty individuals at increased risk for cardiovascular events underwent assessment of renal function by the estimation of glomerular filtration rate (eGFR) and echocardiography227 patients had stages 1–2 CKD (eGFR ≥60 ml/min per 1.73 m), and 113 stages 3–5 (eGFR <60 ml/min per 1.73 m). LVM was predicted in each patient from height, sex and stroke work using a validated equation. iLVM was defined as LVM more than 28% of the predicted value. Sixty-eight healthy individuals served as controls.
RESULTSiLVM was detected in seven controls (10%) and in 146 study patients (43%). There was an inverse relation between observed/predicted LVM ratio and eGFR (r 0.54, P < 0.001). In linear regression analysis, iLVM was related to eGFR (β 0.40), relative wall thickness (β 0.29), diabetes (β 0.14), and maximal left atrial volume (β 0.25) (all P < 0.001). Prevalence of iLVM was 10% in patients in stage-1 CKD, 31% in stage 2, 67% in stage 3, and 100% in stages 4 and 5.
CONCLUSIONIn patients at increased risk for cardiovascular events, iLVM is strongly related to the presence and magnitude of CKD. Further longitudinal studies are needed to evaluate the prognostic value of the coexistence of iLVM and CKD.</description><subject>Adult</subject><subject>Aged</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Chronic Disease</subject><subject>Diabetes Mellitus - pathology</subject><subject>Experimental diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - epidemiology</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>Hypertrophy, Left Ventricular - pathology</subject><subject>Kidney Diseases - complications</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Risk</subject><subject>Ventricular Function, Left</subject><issn>0263-6352</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEUhS1ERUPhDRDyBnU1rX_HniWKKAFVYgPrkcdzTUycmeA7k9BH4K1xSCgSC6QreXG-c691DiGvOLvhrDG3q4-rG9YxLkEKK5VQ3NonZMGVkZXWjX1KFkzUsqqlFpfkOeI3xphtjHxGLgXnmtWyXpCfy3Ueh-jpJvYDPNA-IjgECin6OCGFHx4Q4x5oHHz-LcWBJggT3cMw5ejn5DLdOkT6NY-HaX3Ud26KRUXqpkdfT3PEDQ1jpt7lPo57hyczHDfhC3IRXEJ4eX6vyJe7d5-Xq-r-0_sPy7f3lZdW20p0moEMDXciOKU6ybUXNe-MbRrppQdm6xCMCbWqlRfBS2UFcCl94NCVpK7I9WnvLo_fZ8Cp3Ub0kJIbYJyxtZqbMtYUUp1In0fEDKHd5bh1-aHlrD120JYO2n87KLbX5wNzt4X-0fQn9AK8OQMlAZdCdoOP-JeTtqkN04WzJ-4wpgkybtJ8gNyuwaVp_f8__AJlW6Qd</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Cioffi, Giovanni</creator><creator>Tarantini, Luigi</creator><creator>Frizzi, Roberto</creator><creator>Stefenelli, Carlo</creator><creator>Russo, Tiziano E</creator><creator>Selmi, Alessandro</creator><creator>Toller, Chiara</creator><creator>Furlanello, Francesco</creator><creator>de Simone, Giovanni</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Chronic kidney disease elicits excessive increase in left ventricular mass growth in patients at increased risk for cardiovascular events</title><author>Cioffi, Giovanni ; Tarantini, Luigi ; Frizzi, Roberto ; Stefenelli, Carlo ; Russo, Tiziano E ; Selmi, Alessandro ; Toller, Chiara ; Furlanello, Francesco ; de Simone, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3858-2b50e3f91a2fa44b315c261b78993c3ce086ff77f6464c2fc3482e133cf1eb283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Chronic Disease</topic><topic>Diabetes Mellitus - pathology</topic><topic>Experimental diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular - epidemiology</topic><topic>Hypertrophy, Left Ventricular - etiology</topic><topic>Hypertrophy, Left Ventricular - pathology</topic><topic>Kidney Diseases - complications</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Risk</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cioffi, Giovanni</creatorcontrib><creatorcontrib>Tarantini, Luigi</creatorcontrib><creatorcontrib>Frizzi, Roberto</creatorcontrib><creatorcontrib>Stefenelli, Carlo</creatorcontrib><creatorcontrib>Russo, Tiziano E</creatorcontrib><creatorcontrib>Selmi, Alessandro</creatorcontrib><creatorcontrib>Toller, Chiara</creatorcontrib><creatorcontrib>Furlanello, Francesco</creatorcontrib><creatorcontrib>de Simone, Giovanni</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cioffi, Giovanni</au><au>Tarantini, Luigi</au><au>Frizzi, Roberto</au><au>Stefenelli, Carlo</au><au>Russo, Tiziano E</au><au>Selmi, Alessandro</au><au>Toller, Chiara</au><au>Furlanello, Francesco</au><au>de Simone, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic kidney disease elicits excessive increase in left ventricular mass growth in patients at increased risk for cardiovascular events</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens</addtitle><date>2011-03</date><risdate>2011</risdate><volume>29</volume><issue>3</issue><spage>565</spage><epage>573</epage><pages>565-573</pages><issn>0263-6352</issn><eissn>1473-5598</eissn><coden>JOHYD3</coden><abstract>BACKGROUNDThe hemodynamic alterations induced by the impairment of renal function explain only in part the development of left ventricular hypertrophy in patients with chronic kidney disease (CKD), who are theoretically exposed to an inappropriate high growth of left ventricular mass (iLVM) due to the activation of neuro-hormonal stressors. Few data are available on the relations between iLVM and renal function.
STUDY DESIGN AND MEASUREMENTSThree hundred and forty individuals at increased risk for cardiovascular events underwent assessment of renal function by the estimation of glomerular filtration rate (eGFR) and echocardiography227 patients had stages 1–2 CKD (eGFR ≥60 ml/min per 1.73 m), and 113 stages 3–5 (eGFR <60 ml/min per 1.73 m). LVM was predicted in each patient from height, sex and stroke work using a validated equation. iLVM was defined as LVM more than 28% of the predicted value. Sixty-eight healthy individuals served as controls.
RESULTSiLVM was detected in seven controls (10%) and in 146 study patients (43%). There was an inverse relation between observed/predicted LVM ratio and eGFR (r 0.54, P < 0.001). In linear regression analysis, iLVM was related to eGFR (β 0.40), relative wall thickness (β 0.29), diabetes (β 0.14), and maximal left atrial volume (β 0.25) (all P < 0.001). Prevalence of iLVM was 10% in patients in stage-1 CKD, 31% in stage 2, 67% in stage 3, and 100% in stages 4 and 5.
CONCLUSIONIn patients at increased risk for cardiovascular events, iLVM is strongly related to the presence and magnitude of CKD. Further longitudinal studies are needed to evaluate the prognostic value of the coexistence of iLVM and CKD.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>21150636</pmid><doi>10.1097/HJH.0b013e3283424188</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - etiology Chronic Disease Diabetes Mellitus - pathology Experimental diseases Female Humans Hypertrophy, Left Ventricular - epidemiology Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - pathology Kidney Diseases - complications Linear Models Male Medical sciences Middle Aged Prevalence Risk Ventricular Function, Left |
| title | Chronic kidney disease elicits excessive increase in left ventricular mass growth in patients at increased risk for cardiovascular events |
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