Newly developed strategies for multifunctional mitochondria-targeted agents in cancer therapy
The development of multifunctional agents that could be used for simultaneous tumor targeting, imaging and treatment is a major goal in cancer research and is expected to contribute significantly to the realization of personalized oncology. Mitochondria are involved in diverse physiological activiti...
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| Veröffentlicht in: | Drug discovery today 2011-02, Vol.16 (3), p.140-146 |
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| container_title | Drug discovery today |
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| creator | Zhang, Erlong Zhang, Chao Su, Yongping Cheng, Tianmin Shi, Chunmeng |
| description | The development of multifunctional agents that could be used for simultaneous tumor targeting, imaging and treatment is a major goal in cancer research and is expected to contribute significantly to the realization of personalized oncology. Mitochondria are involved in diverse physiological activities and confer vital roles in cancer development and progression. Increasing efforts are being made to develop cancer treatment strategies based on various mitochondrial targets and novel mitochondrial drug delivery systems. Multifunctional nanostructures or multifunctional chemical compounds further broaden the current concept of tumor targeting and provide alternative solutions for mitochondrially targeted cancer therapy. |
| doi_str_mv | 10.1016/j.drudis.2010.12.006 |
| format | Article |
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Mitochondria are involved in diverse physiological activities and confer vital roles in cancer development and progression. Increasing efforts are being made to develop cancer treatment strategies based on various mitochondrial targets and novel mitochondrial drug delivery systems. Multifunctional nanostructures or multifunctional chemical compounds further broaden the current concept of tumor targeting and provide alternative solutions for mitochondrially targeted cancer therapy.</description><identifier>ISSN: 1359-6446</identifier><identifier>EISSN: 1878-5832</identifier><identifier>DOI: 10.1016/j.drudis.2010.12.006</identifier><identifier>PMID: 21182981</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Drug Delivery Systems ; Drug Discovery ; General pharmacology ; Humans ; Medical sciences ; Mitochondria - drug effects ; Mitochondria - metabolism ; Molecular Structure ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Neoplasms - pathology ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. 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Mitochondria are involved in diverse physiological activities and confer vital roles in cancer development and progression. Increasing efforts are being made to develop cancer treatment strategies based on various mitochondrial targets and novel mitochondrial drug delivery systems. Multifunctional nanostructures or multifunctional chemical compounds further broaden the current concept of tumor targeting and provide alternative solutions for mitochondrially targeted cancer therapy.</description><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Drug Delivery Systems</subject><subject>Drug Discovery</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Molecular Structure</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. 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Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Erlong</creatorcontrib><creatorcontrib>Zhang, Chao</creatorcontrib><creatorcontrib>Su, Yongping</creatorcontrib><creatorcontrib>Cheng, Tianmin</creatorcontrib><creatorcontrib>Shi, Chunmeng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug discovery today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Erlong</au><au>Zhang, Chao</au><au>Su, Yongping</au><au>Cheng, Tianmin</au><au>Shi, Chunmeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Newly developed strategies for multifunctional mitochondria-targeted agents in cancer therapy</atitle><jtitle>Drug discovery today</jtitle><addtitle>Drug Discov Today</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>16</volume><issue>3</issue><spage>140</spage><epage>146</epage><pages>140-146</pages><issn>1359-6446</issn><eissn>1878-5832</eissn><abstract>The development of multifunctional agents that could be used for simultaneous tumor targeting, imaging and treatment is a major goal in cancer research and is expected to contribute significantly to the realization of personalized oncology. Mitochondria are involved in diverse physiological activities and confer vital roles in cancer development and progression. Increasing efforts are being made to develop cancer treatment strategies based on various mitochondrial targets and novel mitochondrial drug delivery systems. Multifunctional nanostructures or multifunctional chemical compounds further broaden the current concept of tumor targeting and provide alternative solutions for mitochondrially targeted cancer therapy.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21182981</pmid><doi>10.1016/j.drudis.2010.12.006</doi><tpages>7</tpages></addata></record> |
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| ispartof | Drug discovery today, 2011-02, Vol.16 (3), p.140-146 |
| issn | 1359-6446 1878-5832 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Biological and medical sciences Drug Delivery Systems Drug Discovery General pharmacology Humans Medical sciences Mitochondria - drug effects Mitochondria - metabolism Molecular Structure Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments |
| title | Newly developed strategies for multifunctional mitochondria-targeted agents in cancer therapy |
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