Development of nanoparticulate drug delivery systems based on thiolated poly(acrylic acid)
In this study the preparation and stabilization of poly(acrylic acid)-cysteine nanoparticles and incorporation of a fluorescence marked model-compound was investigated. Nanoparticles were prepared by ionic gelation of a poly(acrylic acid)-cysteine conjugate with calcium chloride. Poly(acrylic acid)-...
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| Veröffentlicht in: | Journal of microencapsulation 2009-05, Vol.26 (3), p.187-194 |
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| container_title | Journal of microencapsulation |
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| creator | Thaurer, Michael H. Deutel, Britta Schlocker, Wolfgang Bernkop-Schnürch, Andreas |
| description | In this study the preparation and stabilization of poly(acrylic acid)-cysteine nanoparticles and incorporation of a fluorescence marked model-compound was investigated. Nanoparticles were prepared by ionic gelation of a poly(acrylic acid)-cysteine conjugate with calcium chloride. Poly(acrylic acid)-cysteine nanoparticles display high cohesive properties due to a cross-linking process via calcium bridges in the core and the pervasive formation of disulphide bonds and were 139 ± 34 nm in size. Nanoparticles were loaded with FITC-dextrans (flourescein isothiocyanate-dextrans) of 4, 20 and 40 kDa molecular mass as model-compound via sonication method or via vibration method for 3 and 24 h. In vitro release studies showed an initial burst release followed by an extended release of model-compounds. The lower the molecular mass of the FITC-dextrans, the higher was the amount of incorporated and released model compounds. Vibration seems to be a proper method for the incorporation of hydrophilic and macromolecular drugs in poly(acrylic acid)-cysteine nanoparticles. |
| doi_str_mv | 10.1080/02652040802217003 |
| format | Article |
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Nanoparticles were prepared by ionic gelation of a poly(acrylic acid)-cysteine conjugate with calcium chloride. Poly(acrylic acid)-cysteine nanoparticles display high cohesive properties due to a cross-linking process via calcium bridges in the core and the pervasive formation of disulphide bonds and were 139 ± 34 nm in size. Nanoparticles were loaded with FITC-dextrans (flourescein isothiocyanate-dextrans) of 4, 20 and 40 kDa molecular mass as model-compound via sonication method or via vibration method for 3 and 24 h. In vitro release studies showed an initial burst release followed by an extended release of model-compounds. The lower the molecular mass of the FITC-dextrans, the higher was the amount of incorporated and released model compounds. Vibration seems to be a proper method for the incorporation of hydrophilic and macromolecular drugs in poly(acrylic acid)-cysteine nanoparticles.</description><identifier>ISSN: 0265-2048</identifier><identifier>EISSN: 1464-5246</identifier><identifier>DOI: 10.1080/02652040802217003</identifier><identifier>PMID: 18946801</identifier><identifier>CODEN: JOMIEF</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Acrylic Resins - chemistry ; Biological and medical sciences ; cross-linking ; Dextrans - administration & dosage ; Drug Carriers - chemistry ; Fluorescein-5-isothiocyanate - administration & dosage ; Fluorescein-5-isothiocyanate - analogs & derivatives ; General pharmacology ; ionic gelation ; Medical sciences ; mucoadhesion ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; poly(acrylic acid) ; Sulfhydryl Compounds - chemistry ; thiomers</subject><ispartof>Journal of microencapsulation, 2009-05, Vol.26 (3), p.187-194</ispartof><rights>2009 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-149dc75d37fb71ade1d4db825d99d60bd18a7aeb07508d091eb73ff96c9215153</citedby><cites>FETCH-LOGICAL-c466t-149dc75d37fb71ade1d4db825d99d60bd18a7aeb07508d091eb73ff96c9215153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/02652040802217003$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/02652040802217003$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21452491$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18946801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thaurer, Michael H.</creatorcontrib><creatorcontrib>Deutel, Britta</creatorcontrib><creatorcontrib>Schlocker, Wolfgang</creatorcontrib><creatorcontrib>Bernkop-Schnürch, Andreas</creatorcontrib><title>Development of nanoparticulate drug delivery systems based on thiolated poly(acrylic acid)</title><title>Journal of microencapsulation</title><addtitle>J Microencapsul</addtitle><description>In this study the preparation and stabilization of poly(acrylic acid)-cysteine nanoparticles and incorporation of a fluorescence marked model-compound was investigated. Nanoparticles were prepared by ionic gelation of a poly(acrylic acid)-cysteine conjugate with calcium chloride. Poly(acrylic acid)-cysteine nanoparticles display high cohesive properties due to a cross-linking process via calcium bridges in the core and the pervasive formation of disulphide bonds and were 139 ± 34 nm in size. Nanoparticles were loaded with FITC-dextrans (flourescein isothiocyanate-dextrans) of 4, 20 and 40 kDa molecular mass as model-compound via sonication method or via vibration method for 3 and 24 h. In vitro release studies showed an initial burst release followed by an extended release of model-compounds. The lower the molecular mass of the FITC-dextrans, the higher was the amount of incorporated and released model compounds. Vibration seems to be a proper method for the incorporation of hydrophilic and macromolecular drugs in poly(acrylic acid)-cysteine nanoparticles.</description><subject>Acrylic Resins - chemistry</subject><subject>Biological and medical sciences</subject><subject>cross-linking</subject><subject>Dextrans - administration & dosage</subject><subject>Drug Carriers - chemistry</subject><subject>Fluorescein-5-isothiocyanate - administration & dosage</subject><subject>Fluorescein-5-isothiocyanate - analogs & derivatives</subject><subject>General pharmacology</subject><subject>ionic gelation</subject><subject>Medical sciences</subject><subject>mucoadhesion</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>poly(acrylic acid)</subject><subject>Sulfhydryl Compounds - chemistry</subject><subject>thiomers</subject><issn>0265-2048</issn><issn>1464-5246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90cFu1DAQBmALgei28ABckC8UOATGjhM7ohdUoEWqxAUuXKKJPWFTOXGwk6K8fbPaBYSQ9mRL_v6RZ4axZwLeCDDwFmRZSFDrVUqhAfIHbCNUqbJCqvIh2-zesxWYE3aa0i0AFJWRj9mJMJUqDYgN-_6B7siHsadh4qHlAw5hxDh1dvY4EXdx_sEd-e6O4sLTkibqE28wkeNh4NO2Czvn-Bj88gptXHxnOdrOvX7CHrXoEz09nGfs26ePXy-vs5svV58v399kVpXllAlVOasLl-u20QIdCadcY2ThqsqV0DhhUCM1oAswDipBjc7btiptJUUhivyMvdzXHWP4OVOa6r5LlrzHgcKcalMIrbSSZpXnR6UEKQB0uUKxhzaGlCK19Ri7HuNSC6h3o6__G_2aeX4oPjc9ub-Jw6xX8OIAMFn0bcTBdumPk0Kta6t27mLvuqENscdfIXpXT7j4EH-H8mP_ePdPfEvop63FSPVtmOOwruJIF_exi7DM</recordid><startdate>200905</startdate><enddate>200905</enddate><creator>Thaurer, Michael H.</creator><creator>Deutel, Britta</creator><creator>Schlocker, Wolfgang</creator><creator>Bernkop-Schnürch, Andreas</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Informa</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200905</creationdate><title>Development of nanoparticulate drug delivery systems based on thiolated poly(acrylic acid)</title><author>Thaurer, Michael H. ; Deutel, Britta ; Schlocker, Wolfgang ; Bernkop-Schnürch, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-149dc75d37fb71ade1d4db825d99d60bd18a7aeb07508d091eb73ff96c9215153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acrylic Resins - chemistry</topic><topic>Biological and medical sciences</topic><topic>cross-linking</topic><topic>Dextrans - administration & dosage</topic><topic>Drug Carriers - chemistry</topic><topic>Fluorescein-5-isothiocyanate - administration & dosage</topic><topic>Fluorescein-5-isothiocyanate - analogs & derivatives</topic><topic>General pharmacology</topic><topic>ionic gelation</topic><topic>Medical sciences</topic><topic>mucoadhesion</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - ultrastructure</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>poly(acrylic acid)</topic><topic>Sulfhydryl Compounds - chemistry</topic><topic>thiomers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thaurer, Michael H.</creatorcontrib><creatorcontrib>Deutel, Britta</creatorcontrib><creatorcontrib>Schlocker, Wolfgang</creatorcontrib><creatorcontrib>Bernkop-Schnürch, Andreas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of microencapsulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thaurer, Michael H.</au><au>Deutel, Britta</au><au>Schlocker, Wolfgang</au><au>Bernkop-Schnürch, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of nanoparticulate drug delivery systems based on thiolated poly(acrylic acid)</atitle><jtitle>Journal of microencapsulation</jtitle><addtitle>J Microencapsul</addtitle><date>2009-05</date><risdate>2009</risdate><volume>26</volume><issue>3</issue><spage>187</spage><epage>194</epage><pages>187-194</pages><issn>0265-2048</issn><eissn>1464-5246</eissn><coden>JOMIEF</coden><abstract>In this study the preparation and stabilization of poly(acrylic acid)-cysteine nanoparticles and incorporation of a fluorescence marked model-compound was investigated. Nanoparticles were prepared by ionic gelation of a poly(acrylic acid)-cysteine conjugate with calcium chloride. Poly(acrylic acid)-cysteine nanoparticles display high cohesive properties due to a cross-linking process via calcium bridges in the core and the pervasive formation of disulphide bonds and were 139 ± 34 nm in size. Nanoparticles were loaded with FITC-dextrans (flourescein isothiocyanate-dextrans) of 4, 20 and 40 kDa molecular mass as model-compound via sonication method or via vibration method for 3 and 24 h. In vitro release studies showed an initial burst release followed by an extended release of model-compounds. The lower the molecular mass of the FITC-dextrans, the higher was the amount of incorporated and released model compounds. Vibration seems to be a proper method for the incorporation of hydrophilic and macromolecular drugs in poly(acrylic acid)-cysteine nanoparticles.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>18946801</pmid><doi>10.1080/02652040802217003</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Acrylic Resins - chemistry Biological and medical sciences cross-linking Dextrans - administration & dosage Drug Carriers - chemistry Fluorescein-5-isothiocyanate - administration & dosage Fluorescein-5-isothiocyanate - analogs & derivatives General pharmacology ionic gelation Medical sciences mucoadhesion Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments poly(acrylic acid) Sulfhydryl Compounds - chemistry thiomers |
| title | Development of nanoparticulate drug delivery systems based on thiolated poly(acrylic acid) |
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