Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38

SN-38, the active metabolite of irinotecan, poses a challenge in terms of drug delivery due to its low solubility and labile lactone ring. The aim of this study was to develop a SN-38 nanoparticulate delivery system to evaluate the in vivo blood profile and biodistribution properties of nanoparticle...

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Veröffentlicht in:	International journal of pharmaceutics 2011-03, Vol.406 (1), p.122-127
Hauptverfasser:	Ebrahimnejad, Pedram, Dinarvand, Rassoul, Jafari, Mahmoud Reza, Tabasi, Seyed Abolghasem Sajadi, Atyabi, Fatemeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - blood Biodistribution Biological and medical sciences blood Camptothecin - administration & dosage Camptothecin - analogs & derivatives Camptothecin - blood Chemistry, Pharmaceutical Drug Carriers - chemical synthesis Drug Carriers - chemistry drugs Folate targeting folic acid Folic Acid - analogs & derivatives Folic Acid - chemistry General pharmacology Injections, Intravenous intravenous injection Lactic Acid - chemistry liver Medical sciences metabolites Molecular Structure Nanoparticle nanoparticles Nanoparticles - chemistry Nanotechnology Pegylation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLGA polyethylene Polyethylene Glycols - chemistry Polyglycolic Acid - chemistry Rats Rats, Wistar SN-38 solubility spleen Surface Properties tail Tissue Distribution
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