Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38
SN-38, the active metabolite of irinotecan, poses a challenge in terms of drug delivery due to its low solubility and labile lactone ring. The aim of this study was to develop a SN-38 nanoparticulate delivery system to evaluate the in vivo blood profile and biodistribution properties of nanoparticle...
Gespeichert in:
| Veröffentlicht in: | International journal of pharmaceutics 2011-03, Vol.406 (1), p.122-127 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 127 |
|---|---|
| container_issue | 1 |
| container_start_page | 122 |
| container_title | International journal of pharmaceutics |
| container_volume | 406 |
| creator | Ebrahimnejad, Pedram Dinarvand, Rassoul Jafari, Mahmoud Reza Tabasi, Seyed Abolghasem Sajadi Atyabi, Fatemeh |
| description | SN-38, the active metabolite of irinotecan, poses a challenge in terms of drug delivery due to its low solubility and labile lactone ring. The aim of this study was to develop a SN-38 nanoparticulate delivery system to evaluate the
in vivo blood profile and biodistribution properties of nanoparticles (NPs).
Poly lactide-co-glycolide (PLGA) NPs that were covalently bound to polyethylene glycol-folate (PEG-FOL) were prepared, and their
in vivo biodistribution in rats was investigated. Either the SN-38 solution or SN-38 NP suspension was administered intravenously into the tail vein at a dose of 2
mg SN-38 eq./kg. As expected, SN-38 NPs showed a higher plasma concentration
in vivo when compared with free SN-38 during a 24
h period. Compared with the SN-38 solution, both folate targeted and non-targeted NPs exhibited superior drug concentration in body organs such as the liver, spleen, and lung at 1 and 8
h post-administration. |
| doi_str_mv | 10.1016/j.ijpharm.2010.12.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_851747007</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378517310009634</els_id><sourcerecordid>851747007</sourcerecordid><originalsourceid>FETCH-LOGICAL-c484t-b36231fc8366ce85df782c0d6eef7bcbe4d5a8b69cdb7a9c7b4122d030e45bb63</originalsourceid><addsrcrecordid>eNqF0Mtu1DAUBmALgei08AhANqgbMviS2J4VqkZQkEYtUuna8uUYPEriYCdI9OnrKAMsWVk6_s5FP0KvCN4STPj74zYcxx869VuKlxrdYkqfoA2RgtWsEfwp2mAmZN0Swc7Qec5HjDGnhD1HZ5QQ2TLebtCwLzO0nSCFBz2FOLyrTBejq8YUfeig0oOrTIgu5CkFMy9k-RshTQFyFX2V5-S1haovyAdw1dfD9VU16CGOuiDbrezupmbyBXrmdZfh5em9QPefPn7bf64Pt9df9leH2jaymWrDOGXEW8k4tyBb54WkFjsO4IWxBhrXamn4zjoj9M4K0xBKHWYYmtYYzi7Q5Tq3nPpzhjypPmQLXacHiHNWsqTSCIxFke0qbYo5J_BqTKHX6bciWC1Jq6M6Ja2WpBWhqiRd-l6fNsymB_e360-0Bbw9AZ2t7nzSgw35n2NSUCqWQW9W53VU-nsq5v6ubGoxJrTBu0V8WAWUxH4FSCrbAIMFFxLYSbkY_nPsI-zSqaw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>851747007</pqid></control><display><type>article</type><title>Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ebrahimnejad, Pedram ; Dinarvand, Rassoul ; Jafari, Mahmoud Reza ; Tabasi, Seyed Abolghasem Sajadi ; Atyabi, Fatemeh</creator><creatorcontrib>Ebrahimnejad, Pedram ; Dinarvand, Rassoul ; Jafari, Mahmoud Reza ; Tabasi, Seyed Abolghasem Sajadi ; Atyabi, Fatemeh</creatorcontrib><description>SN-38, the active metabolite of irinotecan, poses a challenge in terms of drug delivery due to its low solubility and labile lactone ring. The aim of this study was to develop a SN-38 nanoparticulate delivery system to evaluate the
in vivo blood profile and biodistribution properties of nanoparticles (NPs).
Poly lactide-co-glycolide (PLGA) NPs that were covalently bound to polyethylene glycol-folate (PEG-FOL) were prepared, and their
in vivo biodistribution in rats was investigated. Either the SN-38 solution or SN-38 NP suspension was administered intravenously into the tail vein at a dose of 2
mg SN-38 eq./kg. As expected, SN-38 NPs showed a higher plasma concentration
in vivo when compared with free SN-38 during a 24
h period. Compared with the SN-38 solution, both folate targeted and non-targeted NPs exhibited superior drug concentration in body organs such as the liver, spleen, and lung at 1 and 8
h post-administration.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2010.12.022</identifier><identifier>PMID: 21185365</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - blood ; Biodistribution ; Biological and medical sciences ; blood ; Camptothecin - administration & dosage ; Camptothecin - analogs & derivatives ; Camptothecin - blood ; Chemistry, Pharmaceutical ; Drug Carriers - chemical synthesis ; Drug Carriers - chemistry ; drugs ; Folate targeting ; folic acid ; Folic Acid - analogs & derivatives ; Folic Acid - chemistry ; General pharmacology ; Injections, Intravenous ; intravenous injection ; Lactic Acid - chemistry ; liver ; Medical sciences ; metabolites ; Molecular Structure ; Nanoparticle ; nanoparticles ; Nanoparticles - chemistry ; Nanotechnology ; Pegylation ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; PLGA ; polyethylene ; Polyethylene Glycols - chemistry ; Polyglycolic Acid - chemistry ; Rats ; Rats, Wistar ; SN-38 ; solubility ; spleen ; Surface Properties ; tail ; Tissue Distribution</subject><ispartof>International journal of pharmaceutics, 2011-03, Vol.406 (1), p.122-127</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-b36231fc8366ce85df782c0d6eef7bcbe4d5a8b69cdb7a9c7b4122d030e45bb63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517310009634$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23872272$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21185365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ebrahimnejad, Pedram</creatorcontrib><creatorcontrib>Dinarvand, Rassoul</creatorcontrib><creatorcontrib>Jafari, Mahmoud Reza</creatorcontrib><creatorcontrib>Tabasi, Seyed Abolghasem Sajadi</creatorcontrib><creatorcontrib>Atyabi, Fatemeh</creatorcontrib><title>Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>SN-38, the active metabolite of irinotecan, poses a challenge in terms of drug delivery due to its low solubility and labile lactone ring. The aim of this study was to develop a SN-38 nanoparticulate delivery system to evaluate the
in vivo blood profile and biodistribution properties of nanoparticles (NPs).
Poly lactide-co-glycolide (PLGA) NPs that were covalently bound to polyethylene glycol-folate (PEG-FOL) were prepared, and their
in vivo biodistribution in rats was investigated. Either the SN-38 solution or SN-38 NP suspension was administered intravenously into the tail vein at a dose of 2
mg SN-38 eq./kg. As expected, SN-38 NPs showed a higher plasma concentration
in vivo when compared with free SN-38 during a 24
h period. Compared with the SN-38 solution, both folate targeted and non-targeted NPs exhibited superior drug concentration in body organs such as the liver, spleen, and lung at 1 and 8
h post-administration.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - blood</subject><subject>Biodistribution</subject><subject>Biological and medical sciences</subject><subject>blood</subject><subject>Camptothecin - administration & dosage</subject><subject>Camptothecin - analogs & derivatives</subject><subject>Camptothecin - blood</subject><subject>Chemistry, Pharmaceutical</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>drugs</subject><subject>Folate targeting</subject><subject>folic acid</subject><subject>Folic Acid - analogs & derivatives</subject><subject>Folic Acid - chemistry</subject><subject>General pharmacology</subject><subject>Injections, Intravenous</subject><subject>intravenous injection</subject><subject>Lactic Acid - chemistry</subject><subject>liver</subject><subject>Medical sciences</subject><subject>metabolites</subject><subject>Molecular Structure</subject><subject>Nanoparticle</subject><subject>nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanotechnology</subject><subject>Pegylation</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>PLGA</subject><subject>polyethylene</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>SN-38</subject><subject>solubility</subject><subject>spleen</subject><subject>Surface Properties</subject><subject>tail</subject><subject>Tissue Distribution</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Mtu1DAUBmALgei08AhANqgbMviS2J4VqkZQkEYtUuna8uUYPEriYCdI9OnrKAMsWVk6_s5FP0KvCN4STPj74zYcxx869VuKlxrdYkqfoA2RgtWsEfwp2mAmZN0Swc7Qec5HjDGnhD1HZ5QQ2TLebtCwLzO0nSCFBz2FOLyrTBejq8YUfeig0oOrTIgu5CkFMy9k-RshTQFyFX2V5-S1haovyAdw1dfD9VU16CGOuiDbrezupmbyBXrmdZfh5em9QPefPn7bf64Pt9df9leH2jaymWrDOGXEW8k4tyBb54WkFjsO4IWxBhrXamn4zjoj9M4K0xBKHWYYmtYYzi7Q5Tq3nPpzhjypPmQLXacHiHNWsqTSCIxFke0qbYo5J_BqTKHX6bciWC1Jq6M6Ja2WpBWhqiRd-l6fNsymB_e360-0Bbw9AZ2t7nzSgw35n2NSUCqWQW9W53VU-nsq5v6ubGoxJrTBu0V8WAWUxH4FSCrbAIMFFxLYSbkY_nPsI-zSqaw</recordid><startdate>20110315</startdate><enddate>20110315</enddate><creator>Ebrahimnejad, Pedram</creator><creator>Dinarvand, Rassoul</creator><creator>Jafari, Mahmoud Reza</creator><creator>Tabasi, Seyed Abolghasem Sajadi</creator><creator>Atyabi, Fatemeh</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110315</creationdate><title>Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38</title><author>Ebrahimnejad, Pedram ; Dinarvand, Rassoul ; Jafari, Mahmoud Reza ; Tabasi, Seyed Abolghasem Sajadi ; Atyabi, Fatemeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-b36231fc8366ce85df782c0d6eef7bcbe4d5a8b69cdb7a9c7b4122d030e45bb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - administration & dosage</topic><topic>Antineoplastic Agents, Phytogenic - blood</topic><topic>Biodistribution</topic><topic>Biological and medical sciences</topic><topic>blood</topic><topic>Camptothecin - administration & dosage</topic><topic>Camptothecin - analogs & derivatives</topic><topic>Camptothecin - blood</topic><topic>Chemistry, Pharmaceutical</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Drug Carriers - chemistry</topic><topic>drugs</topic><topic>Folate targeting</topic><topic>folic acid</topic><topic>Folic Acid - analogs & derivatives</topic><topic>Folic Acid - chemistry</topic><topic>General pharmacology</topic><topic>Injections, Intravenous</topic><topic>intravenous injection</topic><topic>Lactic Acid - chemistry</topic><topic>liver</topic><topic>Medical sciences</topic><topic>metabolites</topic><topic>Molecular Structure</topic><topic>Nanoparticle</topic><topic>nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanotechnology</topic><topic>Pegylation</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>PLGA</topic><topic>polyethylene</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>SN-38</topic><topic>solubility</topic><topic>spleen</topic><topic>Surface Properties</topic><topic>tail</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ebrahimnejad, Pedram</creatorcontrib><creatorcontrib>Dinarvand, Rassoul</creatorcontrib><creatorcontrib>Jafari, Mahmoud Reza</creatorcontrib><creatorcontrib>Tabasi, Seyed Abolghasem Sajadi</creatorcontrib><creatorcontrib>Atyabi, Fatemeh</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ebrahimnejad, Pedram</au><au>Dinarvand, Rassoul</au><au>Jafari, Mahmoud Reza</au><au>Tabasi, Seyed Abolghasem Sajadi</au><au>Atyabi, Fatemeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2011-03-15</date><risdate>2011</risdate><volume>406</volume><issue>1</issue><spage>122</spage><epage>127</epage><pages>122-127</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>SN-38, the active metabolite of irinotecan, poses a challenge in terms of drug delivery due to its low solubility and labile lactone ring. The aim of this study was to develop a SN-38 nanoparticulate delivery system to evaluate the
in vivo blood profile and biodistribution properties of nanoparticles (NPs).
Poly lactide-co-glycolide (PLGA) NPs that were covalently bound to polyethylene glycol-folate (PEG-FOL) were prepared, and their
in vivo biodistribution in rats was investigated. Either the SN-38 solution or SN-38 NP suspension was administered intravenously into the tail vein at a dose of 2
mg SN-38 eq./kg. As expected, SN-38 NPs showed a higher plasma concentration
in vivo when compared with free SN-38 during a 24
h period. Compared with the SN-38 solution, both folate targeted and non-targeted NPs exhibited superior drug concentration in body organs such as the liver, spleen, and lung at 1 and 8
h post-administration.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21185365</pmid><doi>10.1016/j.ijpharm.2010.12.022</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2011-03, Vol.406 (1), p.122-127 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_851747007 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - blood Biodistribution Biological and medical sciences blood Camptothecin - administration & dosage Camptothecin - analogs & derivatives Camptothecin - blood Chemistry, Pharmaceutical Drug Carriers - chemical synthesis Drug Carriers - chemistry drugs Folate targeting folic acid Folic Acid - analogs & derivatives Folic Acid - chemistry General pharmacology Injections, Intravenous intravenous injection Lactic Acid - chemistry liver Medical sciences metabolites Molecular Structure Nanoparticle nanoparticles Nanoparticles - chemistry Nanotechnology Pegylation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLGA polyethylene Polyethylene Glycols - chemistry Polyglycolic Acid - chemistry Rats Rats, Wistar SN-38 solubility spleen Surface Properties tail Tissue Distribution |
| title | Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T20%3A16%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characterization,%20blood%20profile%20and%20biodistribution%20properties%20of%20surface%20modified%20PLGA%20nanoparticles%20of%20SN-38&rft.jtitle=International%20journal%20of%20pharmaceutics&rft.au=Ebrahimnejad,%20Pedram&rft.date=2011-03-15&rft.volume=406&rft.issue=1&rft.spage=122&rft.epage=127&rft.pages=122-127&rft.issn=0378-5173&rft.eissn=1873-3476&rft.coden=IJPHDE&rft_id=info:doi/10.1016/j.ijpharm.2010.12.022&rft_dat=%3Cproquest_cross%3E851747007%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=851747007&rft_id=info:pmid/21185365&rft_els_id=S0378517310009634&rfr_iscdi=true |