PLC regulation: emerging pictures for molecular mechanisms
Phosphoinositide-specific phospholipase C (PLC) enzymes are common signalling components linked to the activation of most cellular receptors. All PLC families are complex, modular, multi-domain proteins and together cover a broad spectrum of regulatory interactions, including direct binding to G pro...
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| Veröffentlicht in: | Trends in biochemical sciences (Amsterdam. Regular ed.) 2011-02, Vol.36 (2), p.88-96 |
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| container_title | Trends in biochemical sciences (Amsterdam. Regular ed.) |
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| creator | Bunney, Tom D. Katan, Matilda |
| description | Phosphoinositide-specific phospholipase C (PLC) enzymes are common signalling components linked to the activation of most cellular receptors. All PLC families are complex, modular, multi-domain proteins and together cover a broad spectrum of regulatory interactions, including direct binding to G protein subunits, small GTPases from Rho and Ras families, receptor and non-receptor tyrosine kinases and lipid components of cellular membranes. Recent structural determinations of PLC components and their complexes with regulatory proteins and direct mechanistic studies, together with earlier work, have provided the foundation to propose molecular mechanisms that stringently regulate PLC activity. |
| doi_str_mv | 10.1016/j.tibs.2010.08.003 |
| format | Article |
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| ispartof | Trends in biochemical sciences (Amsterdam. Regular ed.), 2011-02, Vol.36 (2), p.88-96 |
| issn | 0968-0004 1362-4326 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Collection |
| subjects | Animals Cell Membrane - enzymology cell membranes Enzyme Activation GTP Phosphohydrolases - metabolism GTP-Binding Proteins - metabolism guanosinetriphosphatase Humans Models, Molecular Phosphoinositide Phospholipase C - chemistry Phosphoinositide Phospholipase C - metabolism phospholipase C phosphotransferases (kinases) protein subunits proteins receptors regulatory proteins Signal Transduction tyrosine |
| title | PLC regulation: emerging pictures for molecular mechanisms |
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