$A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo‐controlled trial$

A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo‐controlled trial

Fibroblast growth factor 2 (FGF‐2) is a potent mitogen for mesenchymal cells, and a local application of recombinant human FGF‐2 (rhFGF‐2) in a gelatin hydrogel has been reported to accelerate bone union in our animal studies and preparatory dose‐escalation trial on patients with surgical osteotomy....

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Veröffentlicht in:	Journal of bone and mineral research 2010-12, Vol.25 (12), p.2735-2743
Hauptverfasser:	Kawaguchi, Hiroshi, Oka, Hiroyuki, Jingushi, Seiya, Izumi, Toshihiro, Fukunaga, Masao, Sato, Katsumi, Matsushita, Takashi, Nakamura, Kozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies - blood Biological and medical sciences CLINICAL TRIAL Diabetes Complications - blood Female FIBROBLAST GROWTH FACTOR Fibroblast Growth Factor 2 - administration & dosage Fibroblast Growth Factor 2 - adverse effects Fibroblast Growth Factor 2 - blood Fibroblast Growth Factor 2 - therapeutic use FRACTURE HEALING Fundamental and applied biological sciences. Psychology Humans Kaplan-Meier Estimate Male Middle Aged Multivariate Analysis Placebos Radiography Recombinant Proteins - administration & dosage Recombinant Proteins - adverse effects Recombinant Proteins - blood Recombinant Proteins - therapeutic use Skeleton and joints Tibial Fractures - blood Tibial Fractures - complications Tibial Fractures - diagnostic imaging Tibial Fractures - drug therapy Vertebrates: osteoarticular system, musculoskeletal system
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