Repeated toluene exposure modifies the acetylation pattern of histones H3 and H4 in the rat brain

▶ Repeated toluene inhalation modifies histones H3–H4 acetylation in the rat brain. ▶ These epigenetic modifications are histone and brain area-specific. ▶ Reward associated areas suffer toluene-induced epigenetic modifications. ▶ In contrast H3–H4 acetylation is not modified by toluene in Central A...

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Veröffentlicht in:	Neuroscience letters 2011-02, Vol.489 (3), p.142-147
Hauptverfasser:	Sánchez-Serrano, S.L., Cruz, S.L., Lamas, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylation - drug effects Administration, Inhalation Amygdala - drug effects Amygdala - enzymology Animals Antibodies Biological and medical sciences Brain Cocaine Drug abuse Drug addiction Enzymes Epigenesis, Genetic - drug effects Epigenetics Ethanol Fundamental and applied biological sciences. Psychology Gene expression Histone acetylation Histone Acetyltransferases - metabolism Histone deacetylase Histone Deacetylases - metabolism Histone H3 Histones Histones - metabolism Inhalation Male Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - enzymology Rats Rats, Wistar Reinforcement Solvents Toluene Toluene - administration & dosage Toluene - toxicity Ventral Tegmental Area - drug effects Ventral Tegmental Area - enzymology Vertebrates: nervous system and sense organs Volatiles
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