Relationships between vascular calcification, calcium metabolism, bone density, and fractures
Factors involved with calcium metabolism, such as serum calcium and phosphate and calcium intake, have been associated with vascular disease in different populations. We investigated whether this association is mediated via increased vascular calcification by assessing relationships between these fa...
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| Veröffentlicht in: | Journal of bone and mineral research 2010-12, Vol.25 (12), p.2777-2785 |
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| container_title | Journal of bone and mineral research |
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| creator | Wang, Tom KM Bolland, Mark J Pelt, Niels C van Horne, Anne M Mason, Barbara H Ames, Ruth W Grey, Andrew B Ruygrok, Peter N Gamble, Greg D Reid, Ian R |
| description | Factors involved with calcium metabolism, such as serum calcium and phosphate and calcium intake, have been associated with vascular disease in different populations. We investigated whether this association is mediated via increased vascular calcification by assessing relationships between these factors and abdominal aortic calcification (AAC) and coronary artery calcification (CAC). A total of 1471 healthy postmenopausal women participated in a 5‐year randomized, placebo‐controlled trial of calcium 1 g/day, and 323 healthy middle‐aged and older men participated in a 2‐year randomized, placebo‐controlled trial of calcium 600 or 1200 mg/day. AAC was assessed on vertebral morphometric images at baseline and follow‐up. Based on computed tomography, 163 men had CAC assessed, on average, 1.5 years after study completion. In elderly women, AAC was positively related to serum calcium (p |
| doi_str_mv | 10.1002/jbmr.183 |
| format | Article |
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We investigated whether this association is mediated via increased vascular calcification by assessing relationships between these factors and abdominal aortic calcification (AAC) and coronary artery calcification (CAC). A total of 1471 healthy postmenopausal women participated in a 5‐year randomized, placebo‐controlled trial of calcium 1 g/day, and 323 healthy middle‐aged and older men participated in a 2‐year randomized, placebo‐controlled trial of calcium 600 or 1200 mg/day. AAC was assessed on vertebral morphometric images at baseline and follow‐up. Based on computed tomography, 163 men had CAC assessed, on average, 1.5 years after study completion. In elderly women, AAC was positively related to serum calcium (p < .001), phosphate (p = .04), and the calcium‐phosphate product (p = .003), but changes in AAC over time and incidence of cardiovascular events were not related to these variables. In middle‐aged men, AAC and CAC were not consistently related to these variables. Neither dietary calcium intake nor calcium supplementation was associated with changes in the prevalence of AAC over time, and calcium supplementation also was not related to CAC scores in men. After adjusting for age, AAC was not associated with low bone mineral density (BMD) at baseline, changes in BMD over time, or fracture incidence. CAC also was not related to baseline BMD. In summary, serum calcium and phosphate are associated with AAC in older women, but dietary calcium intake and calcium supplementation were not associated with changes in AAC over 2 to 5 years. © 2010 American Society for Bone and Mineral Research.</description><identifier>ISSN: 0884-0431</identifier><identifier>EISSN: 1523-4681</identifier><identifier>DOI: 10.1002/jbmr.183</identifier><identifier>PMID: 20641031</identifier><identifier>CODEN: JBMREJ</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; AORTA ; Aorta, Abdominal - metabolism ; Aorta, Abdominal - pathology ; Biological and medical sciences ; BONE DENSITOMETRY ; Bone Density - physiology ; CALCIFICATION ; Calcinosis - blood ; Calcinosis - complications ; CALCIUM ; Calcium - blood ; Calcium - metabolism ; Calcium, Dietary - metabolism ; Cohort Studies ; Female ; Fractures, Bone - blood ; Fractures, Bone - complications ; Fractures, Bone - physiopathology ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; PHOSPHATE ; Phosphates - blood ; Sex Characteristics ; Skeleton and joints ; Vascular Diseases - blood ; Vascular Diseases - complications ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of bone and mineral research, 2010-12, Vol.25 (12), p.2777-2785</ispartof><rights>Copyright © 2010 American Society for Bone and Mineral Research</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 American Society for Bone and Mineral Research.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4773-8a22f3a0270fb53de51ec060594b7da1e02690c599330afaa75ff9be67870d743</citedby><cites>FETCH-LOGICAL-c4773-8a22f3a0270fb53de51ec060594b7da1e02690c599330afaa75ff9be67870d743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbmr.183$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbmr.183$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23619441$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20641031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Tom KM</creatorcontrib><creatorcontrib>Bolland, Mark J</creatorcontrib><creatorcontrib>Pelt, Niels C van</creatorcontrib><creatorcontrib>Horne, Anne M</creatorcontrib><creatorcontrib>Mason, Barbara H</creatorcontrib><creatorcontrib>Ames, Ruth W</creatorcontrib><creatorcontrib>Grey, Andrew B</creatorcontrib><creatorcontrib>Ruygrok, Peter N</creatorcontrib><creatorcontrib>Gamble, Greg D</creatorcontrib><creatorcontrib>Reid, Ian R</creatorcontrib><title>Relationships between vascular calcification, calcium metabolism, bone density, and fractures</title><title>Journal of bone and mineral research</title><addtitle>J Bone Miner Res</addtitle><description>Factors involved with calcium metabolism, such as serum calcium and phosphate and calcium intake, have been associated with vascular disease in different populations. We investigated whether this association is mediated via increased vascular calcification by assessing relationships between these factors and abdominal aortic calcification (AAC) and coronary artery calcification (CAC). A total of 1471 healthy postmenopausal women participated in a 5‐year randomized, placebo‐controlled trial of calcium 1 g/day, and 323 healthy middle‐aged and older men participated in a 2‐year randomized, placebo‐controlled trial of calcium 600 or 1200 mg/day. AAC was assessed on vertebral morphometric images at baseline and follow‐up. Based on computed tomography, 163 men had CAC assessed, on average, 1.5 years after study completion. In elderly women, AAC was positively related to serum calcium (p < .001), phosphate (p = .04), and the calcium‐phosphate product (p = .003), but changes in AAC over time and incidence of cardiovascular events were not related to these variables. In middle‐aged men, AAC and CAC were not consistently related to these variables. Neither dietary calcium intake nor calcium supplementation was associated with changes in the prevalence of AAC over time, and calcium supplementation also was not related to CAC scores in men. After adjusting for age, AAC was not associated with low bone mineral density (BMD) at baseline, changes in BMD over time, or fracture incidence. CAC also was not related to baseline BMD. In summary, serum calcium and phosphate are associated with AAC in older women, but dietary calcium intake and calcium supplementation were not associated with changes in AAC over 2 to 5 years. © 2010 American Society for Bone and Mineral Research.</description><subject>Aged</subject><subject>AORTA</subject><subject>Aorta, Abdominal - metabolism</subject><subject>Aorta, Abdominal - pathology</subject><subject>Biological and medical sciences</subject><subject>BONE DENSITOMETRY</subject><subject>Bone Density - physiology</subject><subject>CALCIFICATION</subject><subject>Calcinosis - blood</subject><subject>Calcinosis - complications</subject><subject>CALCIUM</subject><subject>Calcium - blood</subject><subject>Calcium - metabolism</subject><subject>Calcium, Dietary - metabolism</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Fractures, Bone - blood</subject><subject>Fractures, Bone - complications</subject><subject>Fractures, Bone - physiopathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>PHOSPHATE</subject><subject>Phosphates - blood</subject><subject>Sex Characteristics</subject><subject>Skeleton and joints</subject><subject>Vascular Diseases - blood</subject><subject>Vascular Diseases - complications</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0884-0431</issn><issn>1523-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V2L1DAUBuAgiju7Cv4CKYjoxXQ9-Wxyqcv6xYqw6KWUND3BDGk7Jq3L_HszzuiCoF6FwJNzyPsS8ojCOQVgLzbdkM6p5nfIikrGa6E0vUtWoLWoQXB6Qk5z3gCAkkrdJycMlKDA6Yp8ucZo5zCN-WvY5qrD-QZxrL7b7JZoU-VsdMEH99OsD9dlqAacbTfFkId11U0jVj2OOcy7dWXHvvLJunlJmB-Qe97GjA-P5xn5_Pry08Xb-urjm3cXL69qJ5qG19oy5rkF1oDvJO9RUnSgQBrRNb2lCEwZcNIYzsF6axvpvelQNbqBvhH8jDw7zN2m6duCeW6HkB3GaEecltxqSYUypkTzX0kZ5WC0LPL5PyXVDdNcl4gLffIH3UxLGsuPi1JKUgrM3A50aco5oW-3KQw27VoK7b7Gdl9jecELfXwcuHQD9r_hr94KeHoEpSgbS-CjC_nWcUWNEHtXH9xNiLj768L2_asP1_vFPwCVaLJi</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Wang, Tom KM</creator><creator>Bolland, Mark J</creator><creator>Pelt, Niels C van</creator><creator>Horne, Anne M</creator><creator>Mason, Barbara H</creator><creator>Ames, Ruth W</creator><creator>Grey, Andrew B</creator><creator>Ruygrok, Peter N</creator><creator>Gamble, Greg D</creator><creator>Reid, Ian R</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201012</creationdate><title>Relationships between vascular calcification, calcium metabolism, bone density, and fractures</title><author>Wang, Tom KM ; Bolland, Mark J ; Pelt, Niels C van ; Horne, Anne M ; Mason, Barbara H ; Ames, Ruth W ; Grey, Andrew B ; Ruygrok, Peter N ; Gamble, Greg D ; Reid, Ian R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4773-8a22f3a0270fb53de51ec060594b7da1e02690c599330afaa75ff9be67870d743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>AORTA</topic><topic>Aorta, Abdominal - metabolism</topic><topic>Aorta, Abdominal - pathology</topic><topic>Biological and medical sciences</topic><topic>BONE DENSITOMETRY</topic><topic>Bone Density - physiology</topic><topic>CALCIFICATION</topic><topic>Calcinosis - blood</topic><topic>Calcinosis - complications</topic><topic>CALCIUM</topic><topic>Calcium - blood</topic><topic>Calcium - metabolism</topic><topic>Calcium, Dietary - metabolism</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Fractures, Bone - blood</topic><topic>Fractures, Bone - complications</topic><topic>Fractures, Bone - physiopathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>PHOSPHATE</topic><topic>Phosphates - blood</topic><topic>Sex Characteristics</topic><topic>Skeleton and joints</topic><topic>Vascular Diseases - blood</topic><topic>Vascular Diseases - complications</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Tom KM</creatorcontrib><creatorcontrib>Bolland, Mark J</creatorcontrib><creatorcontrib>Pelt, Niels C van</creatorcontrib><creatorcontrib>Horne, Anne M</creatorcontrib><creatorcontrib>Mason, Barbara H</creatorcontrib><creatorcontrib>Ames, Ruth W</creatorcontrib><creatorcontrib>Grey, Andrew B</creatorcontrib><creatorcontrib>Ruygrok, Peter N</creatorcontrib><creatorcontrib>Gamble, Greg D</creatorcontrib><creatorcontrib>Reid, Ian R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of bone and mineral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Tom KM</au><au>Bolland, Mark J</au><au>Pelt, Niels C van</au><au>Horne, Anne M</au><au>Mason, Barbara H</au><au>Ames, Ruth W</au><au>Grey, Andrew B</au><au>Ruygrok, Peter N</au><au>Gamble, Greg D</au><au>Reid, Ian R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationships between vascular calcification, calcium metabolism, bone density, and fractures</atitle><jtitle>Journal of bone and mineral research</jtitle><addtitle>J Bone Miner Res</addtitle><date>2010-12</date><risdate>2010</risdate><volume>25</volume><issue>12</issue><spage>2777</spage><epage>2785</epage><pages>2777-2785</pages><issn>0884-0431</issn><eissn>1523-4681</eissn><coden>JBMREJ</coden><abstract>Factors involved with calcium metabolism, such as serum calcium and phosphate and calcium intake, have been associated with vascular disease in different populations. We investigated whether this association is mediated via increased vascular calcification by assessing relationships between these factors and abdominal aortic calcification (AAC) and coronary artery calcification (CAC). A total of 1471 healthy postmenopausal women participated in a 5‐year randomized, placebo‐controlled trial of calcium 1 g/day, and 323 healthy middle‐aged and older men participated in a 2‐year randomized, placebo‐controlled trial of calcium 600 or 1200 mg/day. AAC was assessed on vertebral morphometric images at baseline and follow‐up. Based on computed tomography, 163 men had CAC assessed, on average, 1.5 years after study completion. In elderly women, AAC was positively related to serum calcium (p < .001), phosphate (p = .04), and the calcium‐phosphate product (p = .003), but changes in AAC over time and incidence of cardiovascular events were not related to these variables. In middle‐aged men, AAC and CAC were not consistently related to these variables. Neither dietary calcium intake nor calcium supplementation was associated with changes in the prevalence of AAC over time, and calcium supplementation also was not related to CAC scores in men. After adjusting for age, AAC was not associated with low bone mineral density (BMD) at baseline, changes in BMD over time, or fracture incidence. CAC also was not related to baseline BMD. In summary, serum calcium and phosphate are associated with AAC in older women, but dietary calcium intake and calcium supplementation were not associated with changes in AAC over 2 to 5 years. © 2010 American Society for Bone and Mineral Research.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20641031</pmid><doi>10.1002/jbmr.183</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aged AORTA Aorta, Abdominal - metabolism Aorta, Abdominal - pathology Biological and medical sciences BONE DENSITOMETRY Bone Density - physiology CALCIFICATION Calcinosis - blood Calcinosis - complications CALCIUM Calcium - blood Calcium - metabolism Calcium, Dietary - metabolism Cohort Studies Female Fractures, Bone - blood Fractures, Bone - complications Fractures, Bone - physiopathology Fundamental and applied biological sciences. Psychology Humans Male PHOSPHATE Phosphates - blood Sex Characteristics Skeleton and joints Vascular Diseases - blood Vascular Diseases - complications Vertebrates: osteoarticular system, musculoskeletal system |
| title | Relationships between vascular calcification, calcium metabolism, bone density, and fractures |
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