Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats

The purpose of this study was to evaluate the effects of sclerostin inhibition by treatment with a sclerostin antibody (Scl‐AbII) on bone formation, bone mass, and bone strength in an aged, gonad‐intact male rat model. Sixteen‐month‐old male Sprague‐Dawley rats were injected subcutaneously with vehi...

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Veröffentlicht in:	Journal of bone and mineral research 2010-12, Vol.25 (12), p.2647-2656
Hauptverfasser:	Li, Xiaodong, Warmington, Kelly S, Niu, Qing‐Tian, Asuncion, Franklin J, Barrero, Mauricio, Grisanti, Mario, Dwyer, Denise, Stouch, Brian, Thway, Theingi M, Stolina, Marina, Ominsky, Michael S, Kostenuik, Paul J, Simonet, William S, Paszty, Chris, Ke, Hua Zhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon AGING Aging - metabolism Animals Antibodies, Monoclonal - immunology Biological and medical sciences BIOMECHANICS Bone and Bones - anatomy & histology Bone and Bones - cytology Bone and Bones - diagnostic imaging Bone and Bones - metabolism Bone Density - physiology Bone Morphogenetic Proteins - antagonists & inhibitors Bone Morphogenetic Proteins - metabolism Collagen Type I - metabolism Fundamental and applied biological sciences. Psychology Genetic Markers HISTOMORPHOMETRY Male MALE OSTEOPOROSIS Organ Size Osteocalcin - blood Osteogenesis Rats Rats, Sprague-Dawley SCLEROSTIN ANTIBODY Serotonin - blood Skeleton and joints Tomography, X-Ray Computed Vertebrates: osteoarticular system, musculoskeletal system
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