Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes
The green alga Chlamydomonas reinhardtii is a convenient model organism for the study of basic biological processes, including DNA repair investigations. This review is focused on the studies of DNA repair pathways in C. reinhardtii. Emphasis is given to the connection of DNA repair with other cellu...
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| Veröffentlicht in: | Current genetics 2008, Vol.53 (1), p.1-22 |
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| creator | Vlcek, Daniel Sevcovicová, Andrea Sviezená, Barbara Gálová, Eliska Miadoková, Eva |
| description | The green alga
Chlamydomonas reinhardtii
is a convenient model organism for the study of basic biological processes, including DNA repair investigations. This review is focused on the studies of DNA repair pathways in
C. reinhardtii.
Emphasis is given to the connection of DNA repair with other cellular functions, namely the regulation of the cell cycle. Comparison with the results of repair investigations that are already available revealed the presence of all basic repair pathways in
C. reinhardtii
as well as special features characteristic of this alga. Among others, the involvement of
UVSE1
gene in recombinational repair and uniparental inheritance of chloroplast genome, the specific role of
TRXH1
gene in strand break repair, the requirement of
PHR1
gene for full activity of
PHR2
gene, or encoding of two excision repair proteins by the single
REX1
gene. Contrary to yeast, mammals and higher plants,
C. reinhardtii
does not appear to contain the ortholog of
RAD6
gene, which plays an important role in DNA translesion synthesis and mutagenesis. Completed genome sequences will be a basis for molecular analyses allowing to explain the differences that have been observed in DNA repair of this alga in comparison with other model organisms. |
| doi_str_mv | 10.1007/s00294-007-0163-9 |
| format | Article |
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Chlamydomonas reinhardtii
is a convenient model organism for the study of basic biological processes, including DNA repair investigations. This review is focused on the studies of DNA repair pathways in
C. reinhardtii.
Emphasis is given to the connection of DNA repair with other cellular functions, namely the regulation of the cell cycle. Comparison with the results of repair investigations that are already available revealed the presence of all basic repair pathways in
C. reinhardtii
as well as special features characteristic of this alga. Among others, the involvement of
UVSE1
gene in recombinational repair and uniparental inheritance of chloroplast genome, the specific role of
TRXH1
gene in strand break repair, the requirement of
PHR1
gene for full activity of
PHR2
gene, or encoding of two excision repair proteins by the single
REX1
gene. Contrary to yeast, mammals and higher plants,
C. reinhardtii
does not appear to contain the ortholog of
RAD6
gene, which plays an important role in DNA translesion synthesis and mutagenesis. Completed genome sequences will be a basis for molecular analyses allowing to explain the differences that have been observed in DNA repair of this alga in comparison with other model organisms.</description><identifier>ISSN: 0172-8083</identifier><identifier>EISSN: 1432-0983</identifier><identifier>DOI: 10.1007/s00294-007-0163-9</identifier><identifier>PMID: 17992532</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Algae ; Algal Proteins - genetics ; Algal Proteins - metabolism ; Animals ; Aquatic plants ; Autotrophic Processes - genetics ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Cell Cycle - genetics ; Chlamydomonas reinhardtii ; Chlamydomonas reinhardtii - genetics ; Chlamydomonas reinhardtii - metabolism ; Chloroplasts - genetics ; Deoxyribodipyrimidine Photo-Lyase - genetics ; Deoxyribodipyrimidine Photo-Lyase - metabolism ; Deoxyribonucleic acid ; DNA ; DNA Damage - genetics ; DNA Repair - genetics ; DNA, Algal - chemistry ; DNA, Algal - genetics ; DNA, Algal - metabolism ; Eukaryotic Cells - metabolism ; Eukaryotic Cells - physiology ; Life Sciences ; Microbial Genetics and Genomics ; Microbiology ; Models, Genetic ; Phototrophic Processes - genetics ; Plant Sciences ; Proteomics ; Review ; Sequence Homology ; Yeasts</subject><ispartof>Current genetics, 2008, Vol.53 (1), p.1-22</ispartof><rights>Springer-Verlag 2007</rights><rights>Springer-Verlag 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p241t-79fda115d0547c472580457054a8729fe2ad17caf0adadb53343a6eac198cb493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00294-007-0163-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00294-007-0163-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17992532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vlcek, Daniel</creatorcontrib><creatorcontrib>Sevcovicová, Andrea</creatorcontrib><creatorcontrib>Sviezená, Barbara</creatorcontrib><creatorcontrib>Gálová, Eliska</creatorcontrib><creatorcontrib>Miadoková, Eva</creatorcontrib><title>Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes</title><title>Current genetics</title><addtitle>Curr Genet</addtitle><addtitle>Curr Genet</addtitle><description>The green alga
Chlamydomonas reinhardtii
is a convenient model organism for the study of basic biological processes, including DNA repair investigations. This review is focused on the studies of DNA repair pathways in
C. reinhardtii.
Emphasis is given to the connection of DNA repair with other cellular functions, namely the regulation of the cell cycle. Comparison with the results of repair investigations that are already available revealed the presence of all basic repair pathways in
C. reinhardtii
as well as special features characteristic of this alga. Among others, the involvement of
UVSE1
gene in recombinational repair and uniparental inheritance of chloroplast genome, the specific role of
TRXH1
gene in strand break repair, the requirement of
PHR1
gene for full activity of
PHR2
gene, or encoding of two excision repair proteins by the single
REX1
gene. Contrary to yeast, mammals and higher plants,
C. reinhardtii
does not appear to contain the ortholog of
RAD6
gene, which plays an important role in DNA translesion synthesis and mutagenesis. Completed genome sequences will be a basis for molecular analyses allowing to explain the differences that have been observed in DNA repair of this alga in comparison with other model organisms.</description><subject>Algae</subject><subject>Algal Proteins - genetics</subject><subject>Algal Proteins - metabolism</subject><subject>Animals</subject><subject>Aquatic plants</subject><subject>Autotrophic Processes - genetics</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell Cycle - genetics</subject><subject>Chlamydomonas reinhardtii</subject><subject>Chlamydomonas reinhardtii - genetics</subject><subject>Chlamydomonas reinhardtii - metabolism</subject><subject>Chloroplasts - genetics</subject><subject>Deoxyribodipyrimidine Photo-Lyase - genetics</subject><subject>Deoxyribodipyrimidine Photo-Lyase - metabolism</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Damage - genetics</subject><subject>DNA Repair - genetics</subject><subject>DNA, Algal - chemistry</subject><subject>DNA, Algal - genetics</subject><subject>DNA, Algal - metabolism</subject><subject>Eukaryotic Cells - metabolism</subject><subject>Eukaryotic Cells - physiology</subject><subject>Life Sciences</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Models, Genetic</subject><subject>Phototrophic Processes - genetics</subject><subject>Plant Sciences</subject><subject>Proteomics</subject><subject>Review</subject><subject>Sequence Homology</subject><subject>Yeasts</subject><issn>0172-8083</issn><issn>1432-0983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1vFDEMhiMEotvCD-CCIg70NNT52iTcqm35kCp6gXOUnWSYlJlkSDJI--_JaouQOHDya_mxLftF6BWBdwRAXhUAqnnXZAdkyzr9BG0IZ7QDrdhTtAEiaadAsTN0XsoDAKFKy-fojEitqWB0g9JunOx8cGlO0RacfYijza6G8B5b3Kf4y8fgY8Vzcn7C5VCqn_GQMq6jx6Wu7oDTgG--XLfexYaMQ8TLmGqya001p2UMPfbrD5sPqfryAj0b7FT8y8d4gb59uP26-9Td3X_8vLu-6xbKSe2kHpwlRDgQXPZcUqGAC9kyqyTVg6fWEdnbAayzbi8Y48xuve2JVv2ea3aBLk9zl5x-rr5UM4fS-2my0ae1GCUI3yoqoJFv_0sSLbmArWrgm3_Ah7Tm2K4wlArO2rePe18_Qut-9s4sOcztdPPn4w2gJ6C0Uvzu898pBMzRVnOy1Rzl0Vaj2W9FkZN9</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Vlcek, Daniel</creator><creator>Sevcovicová, Andrea</creator><creator>Sviezená, Barbara</creator><creator>Gálová, Eliska</creator><creator>Miadoková, Eva</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>2008</creationdate><title>Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes</title><author>Vlcek, Daniel ; Sevcovicová, Andrea ; Sviezená, Barbara ; Gálová, Eliska ; Miadoková, Eva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p241t-79fda115d0547c472580457054a8729fe2ad17caf0adadb53343a6eac198cb493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Algae</topic><topic>Algal Proteins - 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Chlamydomonas reinhardtii
is a convenient model organism for the study of basic biological processes, including DNA repair investigations. This review is focused on the studies of DNA repair pathways in
C. reinhardtii.
Emphasis is given to the connection of DNA repair with other cellular functions, namely the regulation of the cell cycle. Comparison with the results of repair investigations that are already available revealed the presence of all basic repair pathways in
C. reinhardtii
as well as special features characteristic of this alga. Among others, the involvement of
UVSE1
gene in recombinational repair and uniparental inheritance of chloroplast genome, the specific role of
TRXH1
gene in strand break repair, the requirement of
PHR1
gene for full activity of
PHR2
gene, or encoding of two excision repair proteins by the single
REX1
gene. Contrary to yeast, mammals and higher plants,
C. reinhardtii
does not appear to contain the ortholog of
RAD6
gene, which plays an important role in DNA translesion synthesis and mutagenesis. Completed genome sequences will be a basis for molecular analyses allowing to explain the differences that have been observed in DNA repair of this alga in comparison with other model organisms.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>17992532</pmid><doi>10.1007/s00294-007-0163-9</doi><tpages>22</tpages></addata></record> |
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| ispartof | Current genetics, 2008, Vol.53 (1), p.1-22 |
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| subjects | Algae Algal Proteins - genetics Algal Proteins - metabolism Animals Aquatic plants Autotrophic Processes - genetics Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle - genetics Chlamydomonas reinhardtii Chlamydomonas reinhardtii - genetics Chlamydomonas reinhardtii - metabolism Chloroplasts - genetics Deoxyribodipyrimidine Photo-Lyase - genetics Deoxyribodipyrimidine Photo-Lyase - metabolism Deoxyribonucleic acid DNA DNA Damage - genetics DNA Repair - genetics DNA, Algal - chemistry DNA, Algal - genetics DNA, Algal - metabolism Eukaryotic Cells - metabolism Eukaryotic Cells - physiology Life Sciences Microbial Genetics and Genomics Microbiology Models, Genetic Phototrophic Processes - genetics Plant Sciences Proteomics Review Sequence Homology Yeasts |
| title | Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes |
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