Cilostazol protects mice against endotoxin shock and attenuates LPS-induced cytokine expression in RAW 264.7 macrophages via MAPK inhibition and NF-κB inactivation: Not involved in cAMP mechanisms

Cilostazol, a phosphodiesterase 3 inhibitor, is a platelet aggregation inhibitor and vasodilator that is useful for treating intermittent claudication. Experimental studies have shown that cilostazol has potent anti-inflammatory effects. In the present study, we examined the effect of cilostazol on...

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Veröffentlicht in:	International immunopharmacology 2010-09, Vol.10 (9), p.1077-1085
Hauptverfasser:	Park, Won Sun, Jung, Won-Kyo, Lee, Da-Young, Moon, Chisook, Yea, Sung Su, Park, Sae-Gwang, Seo, Su-Kil, Park, Cheol, Choi, Yung Hyun, Kim, Gi-Young, Choi, Jung Sik, Choi, Il-Whan
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial diseases Bacterial sepsis Biological and medical sciences Cilostazol Cyclic AMP Cytokines Human bacterial diseases Infectious diseases Medical sciences Mitogen-activated protein kinases Nuclear factor-κB Pharmacology. Drug treatments Septic shock
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