Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells

Bisphenol A (BPA) has been considered as an endocrine disruptor due to its ability to interact with estrogen receptors (ERs). While G protein-coupled receptor 30 (GPR30) is a novel estrogen receptor, its role in BPA-induced activation of Erk1/2 remains unknown. Human breast cancer cell lines, MCF-7,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Environmental pollution (1987) 2011-01, Vol.159 (1), p.212-218
Hauptverfasser:	Dong, S., Terasaka, S., Kiyama, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation antagonists Applied sciences Benzhydryl Compounds Biological and medical sciences Bisphenol A Blocking Blotting, Western Breast Breast cancer cells breast neoplasms Breast Neoplasms - enzymology Cancer Cell Line, Tumor Control Enzyme Activation - drug effects Erk1/2 Estrogen receptor estrogen receptors Estrogens Exact sciences and technology Female GPR30 Gynecology. Andrology. Obstetrics Human Humans Mammary gland diseases Medical sciences Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Phenols - toxicity Pollution Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Receptors Receptors, Estrogen Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects Signal Transduction - genetics small interfering RNA transcription (genetics) Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!