IL-15 has innate anti-tumor activity independent of NK and CD8 T cells

IL‐15 can have innate anti‐tumor activity independent of NK and CD8+ T cells and the common gamma chain receptor. The innate immune system is crucial for host defense and immunosurveillance against pathogens and tumor cells. IL‐15 is a pleiotropic cytokine with important effects on cells of the inna...

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Veröffentlicht in:	Journal of leukocyte biology 2010-09, Vol.88 (3), p.529-536
Hauptverfasser:	Davies, Elizabeth, Reid, Sarah, Medina, Maria Fe, Lichty, Brian, Ashkar, Ali A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - immunology Adenoviridae Adenovirus Animals CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell Count Cell Line, Tumor cytokine DNA-Binding Proteins - deficiency DNA-Binding Proteins - metabolism Humans immunity Immunity, Innate - immunology Immunoglobulin gamma-Chains - immunology immunotherapy Interleukin-12 - immunology Interleukin-15 - immunology Killer Cells, Natural - immunology Killer Cells, Natural - pathology Lung - immunology Lung - pathology Macrophages - immunology melanoma Melanoma - immunology Melanoma - pathology Mice Mice, Inbred C57BL mouse model Nitric Oxide - biosynthesis Phenotype Signal Transduction - immunology
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