APRIL and TALL-1 and receptors BCMA and TACI: system for regulating humoral immunity
We report that the tumor neurosis factor homolog APRIL (a proliferation-inducing ligand) stimulates in vitro proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells in vivo . APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmemb...
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| Veröffentlicht in: | Nature immunology 2000-09, Vol.1 (3), p.252-256 |
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| creator | Theill, Lars E Yu, Gang Boone, Tom Delaney, John Hawkins, Nessa Kelley, Michael Ramakrishnan, Meena McCabe, Susan Qiu, Wan-rong Kornuc, Masayo Xia, Xing-Zhong Guo, Jane Stolina, Marina Boyle, William J Sarosi, Ildiko Hsu, Hailing Senaldi, Giorgio |
| description | We report that the tumor neurosis factor homolog APRIL (a proliferation-inducing ligand) stimulates
in vitro
proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells
in vivo
. APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-1 (also called BLyS or BAFF) for receptor binding. Soluble BCMA and TACI specifically prevent binding of APRIL and block APRIL-stimulated proliferation of primary B cells. BCMA-Fc also inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that APRIL and/or TALL-1 signaling via BCMA and/or TACI are required for generation of humoral immunity. Thus, APRIL–TALL-1 and BCMA-TACI form a two ligands–two receptors pathway involved in stimulation of B and T cell function. |
| doi_str_mv | 10.1038/79802 |
| format | Article |
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in vitro
proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells
in vivo
. APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-1 (also called BLyS or BAFF) for receptor binding. Soluble BCMA and TACI specifically prevent binding of APRIL and block APRIL-stimulated proliferation of primary B cells. BCMA-Fc also inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that APRIL and/or TALL-1 signaling via BCMA and/or TACI are required for generation of humoral immunity. Thus, APRIL–TALL-1 and BCMA-TACI form a two ligands–two receptors pathway involved in stimulation of B and T cell function.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/79802</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>APRIL protein ; BCMA protein ; Biomedicine ; Immunology ; Infectious Diseases ; TACI protein ; TALL-1 protein</subject><ispartof>Nature immunology, 2000-09, Vol.1 (3), p.252-256</ispartof><rights>Nature America Inc. 2000</rights><rights>COPYRIGHT 2000 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3792-2cc87de6336dcfc397ea00f872a134356960bb2d911fe82542627050c0a0e1a83</citedby><cites>FETCH-LOGICAL-c3792-2cc87de6336dcfc397ea00f872a134356960bb2d911fe82542627050c0a0e1a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids></links><search><creatorcontrib>Theill, Lars E</creatorcontrib><creatorcontrib>Yu, Gang</creatorcontrib><creatorcontrib>Boone, Tom</creatorcontrib><creatorcontrib>Delaney, John</creatorcontrib><creatorcontrib>Hawkins, Nessa</creatorcontrib><creatorcontrib>Kelley, Michael</creatorcontrib><creatorcontrib>Ramakrishnan, Meena</creatorcontrib><creatorcontrib>McCabe, Susan</creatorcontrib><creatorcontrib>Qiu, Wan-rong</creatorcontrib><creatorcontrib>Kornuc, Masayo</creatorcontrib><creatorcontrib>Xia, Xing-Zhong</creatorcontrib><creatorcontrib>Guo, Jane</creatorcontrib><creatorcontrib>Stolina, Marina</creatorcontrib><creatorcontrib>Boyle, William J</creatorcontrib><creatorcontrib>Sarosi, Ildiko</creatorcontrib><creatorcontrib>Hsu, Hailing</creatorcontrib><creatorcontrib>Senaldi, Giorgio</creatorcontrib><title>APRIL and TALL-1 and receptors BCMA and TACI: system for regulating humoral immunity</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><description>We report that the tumor neurosis factor homolog APRIL (a proliferation-inducing ligand) stimulates
in vitro
proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells
in vivo
. APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-1 (also called BLyS or BAFF) for receptor binding. Soluble BCMA and TACI specifically prevent binding of APRIL and block APRIL-stimulated proliferation of primary B cells. BCMA-Fc also inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that APRIL and/or TALL-1 signaling via BCMA and/or TACI are required for generation of humoral immunity. Thus, APRIL–TALL-1 and BCMA-TACI form a two ligands–two receptors pathway involved in stimulation of B and T cell function.</description><subject>APRIL protein</subject><subject>BCMA protein</subject><subject>Biomedicine</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>TACI protein</subject><subject>TALL-1 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Immunol</stitle><date>2000-09-01</date><risdate>2000</risdate><volume>1</volume><issue>3</issue><spage>252</spage><epage>256</epage><pages>252-256</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>We report that the tumor neurosis factor homolog APRIL (a proliferation-inducing ligand) stimulates
in vitro
proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells
in vivo
. APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-1 (also called BLyS or BAFF) for receptor binding. Soluble BCMA and TACI specifically prevent binding of APRIL and block APRIL-stimulated proliferation of primary B cells. BCMA-Fc also inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that APRIL and/or TALL-1 signaling via BCMA and/or TACI are required for generation of humoral immunity. Thus, APRIL–TALL-1 and BCMA-TACI form a two ligands–two receptors pathway involved in stimulation of B and T cell function.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><doi>10.1038/79802</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_851461502 |
| source | Nature; Alma/SFX Local Collection |
| subjects | APRIL protein BCMA protein Biomedicine Immunology Infectious Diseases TACI protein TALL-1 protein |
| title | APRIL and TALL-1 and receptors BCMA and TACI: system for regulating humoral immunity |
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