Distinct classes of human stem cells that differ in proliferative and self-renewal potential

The composition of the human hematopoietic stem cell compartment is poorly understood due to the absence of experimental tools with which to characterize the developmental program of individual stem cells. We report here that human stem cells differ markedly in their repopulation capacity and self-r...

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Veröffentlicht in:	Nature immunology 2001, Vol.2 (1), p.75-82
Hauptverfasser:	Guenechea, Guillermo, Gan, Olga I., Dorrell, Craig, Dick, John E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biomedical and Life Sciences Biomedicine Bone marrow Cell Division Colony-Forming Units Assay DNA Primers - genetics Fetal Blood - cytology Green Fluorescent Proteins Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - classification Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Heterogeneity Humans Immunology Infant, Newborn Infectious Diseases Life span Luminescent Proteins - genetics Mice Mice, Inbred NOD Mice, SCID Repopulation Stem cells Time Factors Transduction, Genetic Transplantation Transplantation, Heterologous
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