Late effect of pancreatic duct ligation on beta cell function
The effect of pancreatic duct ligation on endocrine function of the pancreas has been studied in the dog for a period of more than seven months. Endocrine insufficiencies were observed in ten of the fifteen dogs (67 per cent) between forty-five and 222 days after ductal ligation as assessed by fasti...
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| Veröffentlicht in: | The American journal of surgery 1969, Vol.117 (1), p.33-39 |
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| container_title | The American journal of surgery |
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| creator | Idezuki, Yasuo Goetz, Frederick C. Lillehei, Richard C. |
| description | The effect of pancreatic duct ligation on endocrine function of the pancreas has been studied in the dog for a period of more than seven months. Endocrine insufficiencies were observed in ten of the fifteen dogs (67 per cent) between forty-five and 222 days after ductal ligation as assessed by fasting blood sugar levels, circulating plasma insulin levels, and intravenous glucose tolerance tests. It has been suggested that severe fibrotic degeneration of the exocrine tissue could lead to secondary endocrine dysfunction. The use of a pancreas with free drainage of the pancreatic secretion as an endocrine transplant for the treatment of diabetes mellitus is therefore recommended. |
| doi_str_mv | 10.1016/0002-9610(69)90282-7 |
| format | Article |
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Endocrine insufficiencies were observed in ten of the fifteen dogs (67 per cent) between forty-five and 222 days after ductal ligation as assessed by fasting blood sugar levels, circulating plasma insulin levels, and intravenous glucose tolerance tests. It has been suggested that severe fibrotic degeneration of the exocrine tissue could lead to secondary endocrine dysfunction. 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Endocrine insufficiencies were observed in ten of the fifteen dogs (67 per cent) between forty-five and 222 days after ductal ligation as assessed by fasting blood sugar levels, circulating plasma insulin levels, and intravenous glucose tolerance tests. It has been suggested that severe fibrotic degeneration of the exocrine tissue could lead to secondary endocrine dysfunction. The use of a pancreas with free drainage of the pancreatic secretion as an endocrine transplant for the treatment of diabetes mellitus is therefore recommended.</description><subject>Animals</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes Mellitus - surgery</subject><subject>Dogs</subject><subject>Glucose Tolerance Test</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Islets of Langerhans - cytology</subject><subject>Islets of Langerhans - physiology</subject><subject>Islets of Langerhans - physiopathology</subject><subject>Pancreas Transplantation</subject><subject>Pancreatic Ducts - physiology</subject><subject>Pancreatic Ducts - surgery</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6Ej1UkyZpkoOCiF-w4EXPIU0mEum2a9IK_ntTd9mjMDDMzDtfD0KnBF8RTOprjHFVqprgi1pdKlzJqhR7aE6kUCWRku6j-U5yiI5S-swhIYzO0IxJWbEKz9HN0gxQgPdgh6L3xdp0NoIZgi3cmFNt-MhB3xXZGhhMYaFtCz92dsoeowNv2gQnW79A748Pb_fP5fL16eX-bllaWouhtA3mnDTWV41ieTX3kjBGFDgAWQvOOCWS145gxUTjqMVGSAkUg3dWAacLdL6Zu4791whp0KuQpktMB_2YtOSEMsqqLGQboY19ShG8XsewMvFHE6wnanpCoickulb6j5oWue1sO39sVuB2TVtMuX67qUN-8jtA1MkG6Cy4EDM47frw_4Jf8_J6KA</recordid><startdate>1969</startdate><enddate>1969</enddate><creator>Idezuki, Yasuo</creator><creator>Goetz, Frederick C.</creator><creator>Lillehei, Richard C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1969</creationdate><title>Late effect of pancreatic duct ligation on beta cell function</title><author>Idezuki, Yasuo ; Goetz, Frederick C. ; Lillehei, Richard C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-cb0551bcf2b944885f814419edee86754531856d10947bd3c0a788e30efdc9e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Animals</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes Mellitus - surgery</topic><topic>Dogs</topic><topic>Glucose Tolerance Test</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Islets of Langerhans - cytology</topic><topic>Islets of Langerhans - physiology</topic><topic>Islets of Langerhans - physiopathology</topic><topic>Pancreas Transplantation</topic><topic>Pancreatic Ducts - physiology</topic><topic>Pancreatic Ducts - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Idezuki, Yasuo</creatorcontrib><creatorcontrib>Goetz, Frederick C.</creatorcontrib><creatorcontrib>Lillehei, Richard C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Idezuki, Yasuo</au><au>Goetz, Frederick C.</au><au>Lillehei, Richard C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Late effect of pancreatic duct ligation on beta cell function</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1969</date><risdate>1969</risdate><volume>117</volume><issue>1</issue><spage>33</spage><epage>39</epage><pages>33-39</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>The effect of pancreatic duct ligation on endocrine function of the pancreas has been studied in the dog for a period of more than seven months. 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| ispartof | The American journal of surgery, 1969, Vol.117 (1), p.33-39 |
| issn | 0002-9610 1879-1883 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Blood Glucose - analysis Diabetes Mellitus - surgery Dogs Glucose Tolerance Test Insulin - blood Insulin - metabolism Insulin Secretion Islets of Langerhans - cytology Islets of Langerhans - physiology Islets of Langerhans - physiopathology Pancreas Transplantation Pancreatic Ducts - physiology Pancreatic Ducts - surgery |
| title | Late effect of pancreatic duct ligation on beta cell function |
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