Inhibition of Rhinovirus by Isatin Thiosemicarbazone Analogues
ISATIN 3-thiosemicarbazone is known to have antiviral activity against certain poxviruses 1,2 . The antiviral spectrum of 1-methylisatin 3-thiosemicarbazone, which reportedly extends to adenoviruses, may be rather broader but is still limited to several groups of DNA viruses 2,3 . It was therefore a...
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| Veröffentlicht in: | Nature (London) 1969-01, Vol.221 (5177), p.286-287 |
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| container_issue | 5177 |
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| container_title | Nature (London) |
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| creator | GLADYCH, J. M. Z HUNT, J. H JACK, D HAFF, R. F BOYLE, J. J STEWART, R. C FERLAUTO, R. J |
| description | ISATIN 3-thiosemicarbazone is known to have antiviral activity against certain poxviruses
1,2
. The antiviral spectrum of 1-methylisatin 3-thiosemicarbazone, which reportedly extends to adenoviruses, may be rather broader but is still limited to several groups of DNA viruses
2,3
. It was therefore an unexpected finding that these compounds are also active against certain rhinoviruses. As a result, related heterocyclic compounds were tested of which several examples are shown here; two (
D
and
E
) were found to have activity against all rhinovirus strains used so far. |
| doi_str_mv | 10.1038/221286b0 |
| format | Article |
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1,2
. The antiviral spectrum of 1-methylisatin 3-thiosemicarbazone, which reportedly extends to adenoviruses, may be rather broader but is still limited to several groups of DNA viruses
2,3
. It was therefore an unexpected finding that these compounds are also active against certain rhinoviruses. As a result, related heterocyclic compounds were tested of which several examples are shown here; two (
D
and
E
) were found to have activity against all rhinovirus strains used so far.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/221286b0</identifier><identifier>PMID: 4303131</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Humanities and Social Sciences ; Indoles - pharmacology ; letter ; multidisciplinary ; Rhinovirus - drug effects ; Rhinovirus - growth & development ; Science ; Science (multidisciplinary) ; Thiosemicarbazones - pharmacology ; Triazines - pharmacology</subject><ispartof>Nature (London), 1969-01, Vol.221 (5177), p.286-287</ispartof><rights>Springer Nature Limited 1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-d356d3761f793576e9e77af77bb3c778ef5805ffde8701e2007dcb479f02ea393</citedby><cites>FETCH-LOGICAL-c335t-d356d3761f793576e9e77af77bb3c778ef5805ffde8701e2007dcb479f02ea393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/221286b0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/221286b0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2726,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4303131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GLADYCH, J. M. Z</creatorcontrib><creatorcontrib>HUNT, J. H</creatorcontrib><creatorcontrib>JACK, D</creatorcontrib><creatorcontrib>HAFF, R. F</creatorcontrib><creatorcontrib>BOYLE, J. J</creatorcontrib><creatorcontrib>STEWART, R. C</creatorcontrib><creatorcontrib>FERLAUTO, R. J</creatorcontrib><title>Inhibition of Rhinovirus by Isatin Thiosemicarbazone Analogues</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>ISATIN 3-thiosemicarbazone is known to have antiviral activity against certain poxviruses
1,2
. The antiviral spectrum of 1-methylisatin 3-thiosemicarbazone, which reportedly extends to adenoviruses, may be rather broader but is still limited to several groups of DNA viruses
2,3
. It was therefore an unexpected finding that these compounds are also active against certain rhinoviruses. As a result, related heterocyclic compounds were tested of which several examples are shown here; two (
D
and
E
) were found to have activity against all rhinovirus strains used so far.</description><subject>Humanities and Social Sciences</subject><subject>Indoles - pharmacology</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Rhinovirus - drug effects</subject><subject>Rhinovirus - growth & development</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Thiosemicarbazones - pharmacology</subject><subject>Triazines - pharmacology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1Lw0AURQdRaq2Cf0DJSnQRfZNJMpONUIofhYIgdR0myZt2SjJTZxKh_nojqV25eot7OI97CbmkcE-BiYcoopFICzgiYxrzNIxTwY_JGCASIQiWnpIz7zcAkFAej8goZsAoo2PyODdrXehWWxNYFbyvtbFf2nU-KHbB3MtWm2C51tZjo0vpCvltDQZTI2u76tCfkxMla48X-zshH89Py9lruHh7mc-mi7BkLGnDiiVpxXhKFc9YwlPMkHOpOC8KVnIuUCUCEqUqFBwoRgC8KouYZwoilCxjE3IzeLfOfvZ_27zRvsS6lgZt53OR9P0F0B68HcDSWe8dqnzrdCPdLqeQ_06V_03Vo1d7Z1c0WB3A_TZ9fjfkvk_MCl2-sZ3rm_v_XNcDa2TbOTy4DsAPN995-A</recordid><startdate>19690118</startdate><enddate>19690118</enddate><creator>GLADYCH, J. M. Z</creator><creator>HUNT, J. H</creator><creator>JACK, D</creator><creator>HAFF, R. F</creator><creator>BOYLE, J. J</creator><creator>STEWART, R. C</creator><creator>FERLAUTO, R. J</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19690118</creationdate><title>Inhibition of Rhinovirus by Isatin Thiosemicarbazone Analogues</title><author>GLADYCH, J. M. Z ; HUNT, J. H ; JACK, D ; HAFF, R. F ; BOYLE, J. J ; STEWART, R. C ; FERLAUTO, R. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-d356d3761f793576e9e77af77bb3c778ef5805ffde8701e2007dcb479f02ea393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Humanities and Social Sciences</topic><topic>Indoles - pharmacology</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Rhinovirus - drug effects</topic><topic>Rhinovirus - growth & development</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Thiosemicarbazones - pharmacology</topic><topic>Triazines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GLADYCH, J. M. Z</creatorcontrib><creatorcontrib>HUNT, J. H</creatorcontrib><creatorcontrib>JACK, D</creatorcontrib><creatorcontrib>HAFF, R. F</creatorcontrib><creatorcontrib>BOYLE, J. J</creatorcontrib><creatorcontrib>STEWART, R. C</creatorcontrib><creatorcontrib>FERLAUTO, R. J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GLADYCH, J. M. Z</au><au>HUNT, J. H</au><au>JACK, D</au><au>HAFF, R. F</au><au>BOYLE, J. J</au><au>STEWART, R. C</au><au>FERLAUTO, R. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Rhinovirus by Isatin Thiosemicarbazone Analogues</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1969-01-18</date><risdate>1969</risdate><volume>221</volume><issue>5177</issue><spage>286</spage><epage>287</epage><pages>286-287</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>ISATIN 3-thiosemicarbazone is known to have antiviral activity against certain poxviruses
1,2
. The antiviral spectrum of 1-methylisatin 3-thiosemicarbazone, which reportedly extends to adenoviruses, may be rather broader but is still limited to several groups of DNA viruses
2,3
. It was therefore an unexpected finding that these compounds are also active against certain rhinoviruses. As a result, related heterocyclic compounds were tested of which several examples are shown here; two (
D
and
E
) were found to have activity against all rhinovirus strains used so far.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>4303131</pmid><doi>10.1038/221286b0</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1969-01, Vol.221 (5177), p.286-287 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Humanities and Social Sciences Indoles - pharmacology letter multidisciplinary Rhinovirus - drug effects Rhinovirus - growth & development Science Science (multidisciplinary) Thiosemicarbazones - pharmacology Triazines - pharmacology |
| title | Inhibition of Rhinovirus by Isatin Thiosemicarbazone Analogues |
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