A chromosome survey of 2,400 normal newborn infants
In order to ascertain the variety and frequency of chromosome abnormalities among normal individuals, a chromosome survey of a large number of newborn infants is in progress. This report describes the results obtained from an abbreviated chromosome analysis of 2,400 phenotypically normal newborn inf...
Gespeichert in:
| Veröffentlicht in: | The Journal of pediatrics 1969-03, Vol.74 (3), p.438-448 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 448 |
|---|---|
| container_issue | 3 |
| container_start_page | 438 |
| container_title | The Journal of pediatrics |
| container_volume | 74 |
| creator | Walzer, Stanley Breau, Germaine Gerald, Park S. |
| description | In order to ascertain the variety and frequency of chromosome abnormalities among normal individuals, a chromosome survey of a large number of newborn infants is in progress. This report describes the results obtained from an abbreviated chromosome analysis of 2,400 phenotypically normal newborn infants. Even though this method provides only a minimal estimate, 13 major chromosome abnormalities were observed. These included 4 instances of sex-chromosome aneuploidy and 9 instances of structural rearrangements. Two instances of the centric fusion type of D/D translocation and 3 instances of an extra, small, metacentric chromosome in addition to a normal karyotype were observed. |
| doi_str_mv | 10.1016/S0022-3476(69)80202-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_85128682</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347669802027</els_id><sourcerecordid>85128682</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-438d0ef51e44109e06e784ed40b262e12486d636dfaddd6e8d4e11e11217081e3</originalsourceid><addsrcrecordid>eNqFkEtLw0AUhQdRaq3-hEJWomD0ziMzk5WU4gsKLtT1kGZucCTJ1Jmk0n9v-sCtcOEuzjn38REypXBLgcq7NwDGUi6UvJL5tQYGLFVHZEwhV6nUnB-T8Z_llJzF-AUAuQAYkVGmpFBKjwmfJeVn8I2PvsEk9mGNm8RXCbsZjEnrQ1PUSYs_Sx_axLVV0XbxnJxURR3x4tAn5OPx4X3-nC5en17ms0VacgldKri2gFVGUYjhKASJSgu0ApZMMqRMaGkll7YqrLUStRVI6VCMKtAU-YRc7ueugv_uMXamcbHEui5a9H00OqNMS80GY7Y3lsHHGLAyq-CaImwMBbOFZXawzJaEkbnZwTJqyE0PC_plg_YvdaAz6Pd7HYcv1w6DiaXDtkTrApadsd79s-EXD2N21g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>85128682</pqid></control><display><type>article</type><title>A chromosome survey of 2,400 normal newborn infants</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Walzer, Stanley ; Breau, Germaine ; Gerald, Park S.</creator><creatorcontrib>Walzer, Stanley ; Breau, Germaine ; Gerald, Park S.</creatorcontrib><description>In order to ascertain the variety and frequency of chromosome abnormalities among normal individuals, a chromosome survey of a large number of newborn infants is in progress. This report describes the results obtained from an abbreviated chromosome analysis of 2,400 phenotypically normal newborn infants. Even though this method provides only a minimal estimate, 13 major chromosome abnormalities were observed. These included 4 instances of sex-chromosome aneuploidy and 9 instances of structural rearrangements. Two instances of the centric fusion type of D/D translocation and 3 instances of an extra, small, metacentric chromosome in addition to a normal karyotype were observed.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(69)80202-7</identifier><identifier>PMID: 5764778</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Asian People ; Black or African American ; Black People ; Chromosome Aberrations - epidemiology ; Chromosome Aberrations - genetics ; Chromosome Disorders ; Chromosomes, Human, 13-15 ; Chromosomes, Human, 6-12 and X ; Family Characteristics ; Female ; Humans ; Infant, Newborn ; Male ; Mass Screening ; Massachusetts ; Maternal Age ; Parity ; Pedigree ; Phenotype ; Sex Chromosome Aberrations - epidemiology ; White People</subject><ispartof>The Journal of pediatrics, 1969-03, Vol.74 (3), p.438-448</ispartof><rights>1969 The C. V. Mosby Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-438d0ef51e44109e06e784ed40b262e12486d636dfaddd6e8d4e11e11217081e3</citedby><cites>FETCH-LOGICAL-c360t-438d0ef51e44109e06e784ed40b262e12486d636dfaddd6e8d4e11e11217081e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347669802027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5764778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walzer, Stanley</creatorcontrib><creatorcontrib>Breau, Germaine</creatorcontrib><creatorcontrib>Gerald, Park S.</creatorcontrib><title>A chromosome survey of 2,400 normal newborn infants</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>In order to ascertain the variety and frequency of chromosome abnormalities among normal individuals, a chromosome survey of a large number of newborn infants is in progress. This report describes the results obtained from an abbreviated chromosome analysis of 2,400 phenotypically normal newborn infants. Even though this method provides only a minimal estimate, 13 major chromosome abnormalities were observed. These included 4 instances of sex-chromosome aneuploidy and 9 instances of structural rearrangements. Two instances of the centric fusion type of D/D translocation and 3 instances of an extra, small, metacentric chromosome in addition to a normal karyotype were observed.</description><subject>Asian People</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Chromosome Aberrations - epidemiology</subject><subject>Chromosome Aberrations - genetics</subject><subject>Chromosome Disorders</subject><subject>Chromosomes, Human, 13-15</subject><subject>Chromosomes, Human, 6-12 and X</subject><subject>Family Characteristics</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Massachusetts</subject><subject>Maternal Age</subject><subject>Parity</subject><subject>Pedigree</subject><subject>Phenotype</subject><subject>Sex Chromosome Aberrations - epidemiology</subject><subject>White People</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AUhQdRaq3-hEJWomD0ziMzk5WU4gsKLtT1kGZucCTJ1Jmk0n9v-sCtcOEuzjn38REypXBLgcq7NwDGUi6UvJL5tQYGLFVHZEwhV6nUnB-T8Z_llJzF-AUAuQAYkVGmpFBKjwmfJeVn8I2PvsEk9mGNm8RXCbsZjEnrQ1PUSYs_Sx_axLVV0XbxnJxURR3x4tAn5OPx4X3-nC5en17ms0VacgldKri2gFVGUYjhKASJSgu0ApZMMqRMaGkll7YqrLUStRVI6VCMKtAU-YRc7ueugv_uMXamcbHEui5a9H00OqNMS80GY7Y3lsHHGLAyq-CaImwMBbOFZXawzJaEkbnZwTJqyE0PC_plg_YvdaAz6Pd7HYcv1w6DiaXDtkTrApadsd79s-EXD2N21g</recordid><startdate>196903</startdate><enddate>196903</enddate><creator>Walzer, Stanley</creator><creator>Breau, Germaine</creator><creator>Gerald, Park S.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196903</creationdate><title>A chromosome survey of 2,400 normal newborn infants</title><author>Walzer, Stanley ; Breau, Germaine ; Gerald, Park S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-438d0ef51e44109e06e784ed40b262e12486d636dfaddd6e8d4e11e11217081e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Asian People</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Chromosome Aberrations - epidemiology</topic><topic>Chromosome Aberrations - genetics</topic><topic>Chromosome Disorders</topic><topic>Chromosomes, Human, 13-15</topic><topic>Chromosomes, Human, 6-12 and X</topic><topic>Family Characteristics</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Massachusetts</topic><topic>Maternal Age</topic><topic>Parity</topic><topic>Pedigree</topic><topic>Phenotype</topic><topic>Sex Chromosome Aberrations - epidemiology</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walzer, Stanley</creatorcontrib><creatorcontrib>Breau, Germaine</creatorcontrib><creatorcontrib>Gerald, Park S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walzer, Stanley</au><au>Breau, Germaine</au><au>Gerald, Park S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A chromosome survey of 2,400 normal newborn infants</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1969-03</date><risdate>1969</risdate><volume>74</volume><issue>3</issue><spage>438</spage><epage>448</epage><pages>438-448</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>In order to ascertain the variety and frequency of chromosome abnormalities among normal individuals, a chromosome survey of a large number of newborn infants is in progress. This report describes the results obtained from an abbreviated chromosome analysis of 2,400 phenotypically normal newborn infants. Even though this method provides only a minimal estimate, 13 major chromosome abnormalities were observed. These included 4 instances of sex-chromosome aneuploidy and 9 instances of structural rearrangements. Two instances of the centric fusion type of D/D translocation and 3 instances of an extra, small, metacentric chromosome in addition to a normal karyotype were observed.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>5764778</pmid><doi>10.1016/S0022-3476(69)80202-7</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 1969-03, Vol.74 (3), p.438-448 |
| issn | 0022-3476 1097-6833 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_85128682 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Asian People Black or African American Black People Chromosome Aberrations - epidemiology Chromosome Aberrations - genetics Chromosome Disorders Chromosomes, Human, 13-15 Chromosomes, Human, 6-12 and X Family Characteristics Female Humans Infant, Newborn Male Mass Screening Massachusetts Maternal Age Parity Pedigree Phenotype Sex Chromosome Aberrations - epidemiology White People |
| title | A chromosome survey of 2,400 normal newborn infants |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T17%3A10%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20chromosome%20survey%20of%202,400%20normal%20newborn%20infants&rft.jtitle=The%20Journal%20of%20pediatrics&rft.au=Walzer,%20Stanley&rft.date=1969-03&rft.volume=74&rft.issue=3&rft.spage=438&rft.epage=448&rft.pages=438-448&rft.issn=0022-3476&rft.eissn=1097-6833&rft_id=info:doi/10.1016/S0022-3476(69)80202-7&rft_dat=%3Cproquest_cross%3E85128682%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=85128682&rft_id=info:pmid/5764778&rft_els_id=S0022347669802027&rfr_iscdi=true |