Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency

Pten inactivation promotes cell survival in leukemia cells by activating glycolytic metabolism. We found that targeting ribosomal protein S6 kinase 1 (S6K1) in Pten-deficient cells suppressed glycolysis and induced apoptosis. S6K1 knockdown decreased expression of HIF-1α, and HIF-1α was sufficient t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (6), p.2361-2365
Hauptverfasser:	Tandon, Preeti, Gallo, Catherine A, Khatri, Shikha, Barger, Jennifer F, Yepiskoposyan, Hasmik, Plas, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Biological Sciences Bone marrow cells Cancer Cell growth Cell Line, Tumor Cell lines Cells Cellular metabolism Cultured cells Disease Models, Animal Gene expression Gene expression regulation Gene Knockdown Techniques Glycolysis Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Kinases Leukemia Leukemia - enzymology Leukemia - genetics Metabolism Mice Mice, Knockout Neoplasm Proteins - genetics Neoplasm Proteins - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Ribosomal Protein S6 Kinases, 90-kDa - genetics Ribosomal Protein S6 Kinases, 90-kDa - metabolism Rodents Survival analysis Viability
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