Sodium Current in Ventricular Myocardial Fibers
Membrane currents were measured in thin bundles of dog ventricular myocardium under voltage-clamp conditions. A rather large initial inward current which had an equilibrium potential at about + 55 millivolts could be recorded. When the external sodium concentration was reduced, the equilibrium poten...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1969-01, Vol.163 (3865), p.397-399 |
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| container_issue | 3865 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Reuter, Harald Beeler, George W. |
| description | Membrane currents were measured in thin bundles of dog ventricular myocardium under voltage-clamp conditions. A rather large initial inward current which had an equilibrium potential at about + 55 millivolts could be recorded. When the external sodium concentration was reduced, the equilibrium potential for this current was shifted by the amount predicted theoretically for a current carried solely by sodium ions. The size of the sodium inward current (I$_{Na}$) was largely dependent on the preceding membrane potential. The I$_{Na}$ was completely inactivated if the membrane potential was as low as - 45 millivolts. Sodium ions are the main carrier of charge during the rapid depolarization phase of the action potential. |
| doi_str_mv | 10.1126/science.163.3865.397 |
| format | Article |
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A rather large initial inward current which had an equilibrium potential at about + 55 millivolts could be recorded. When the external sodium concentration was reduced, the equilibrium potential for this current was shifted by the amount predicted theoretically for a current carried solely by sodium ions. The size of the sodium inward current (I$_{Na}$) was largely dependent on the preceding membrane potential. The I$_{Na}$ was completely inactivated if the membrane potential was as low as - 45 millivolts. Sodium ions are the main carrier of charge during the rapid depolarization phase of the action potential.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.163.3865.397</identifier><identifier>PMID: 5762778</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Action Potentials ; Animals ; Depolarization ; Dogs ; Electric current ; Electric potential ; Heart ; Heart - physiology ; Heart Ventricles ; In Vitro Techniques ; Ion currents ; Ions ; Membrane potential ; Membrane Potentials ; Myocardium ; P branes ; Papillary Muscles - physiology ; Sodium ; Sodium - physiology ; String theory</subject><ispartof>Science (American Association for the Advancement of Science), 1969-01, Vol.163 (3865), p.397-399</ispartof><rights>Copyright 1969 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-fcd978abb03abb4cdbdcaefef0e3819f0eb6d52cd4f1b5fae74c3e2403ca1c333</citedby><cites>FETCH-LOGICAL-c419t-fcd978abb03abb4cdbdcaefef0e3819f0eb6d52cd4f1b5fae74c3e2403ca1c333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1725027$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1725027$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5762778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reuter, Harald</creatorcontrib><creatorcontrib>Beeler, George W.</creatorcontrib><title>Sodium Current in Ventricular Myocardial Fibers</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Membrane currents were measured in thin bundles of dog ventricular myocardium under voltage-clamp conditions. A rather large initial inward current which had an equilibrium potential at about + 55 millivolts could be recorded. When the external sodium concentration was reduced, the equilibrium potential for this current was shifted by the amount predicted theoretically for a current carried solely by sodium ions. The size of the sodium inward current (I$_{Na}$) was largely dependent on the preceding membrane potential. The I$_{Na}$ was completely inactivated if the membrane potential was as low as - 45 millivolts. Sodium ions are the main carrier of charge during the rapid depolarization phase of the action potential.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>Depolarization</subject><subject>Dogs</subject><subject>Electric current</subject><subject>Electric potential</subject><subject>Heart</subject><subject>Heart - physiology</subject><subject>Heart Ventricles</subject><subject>In Vitro Techniques</subject><subject>Ion currents</subject><subject>Ions</subject><subject>Membrane potential</subject><subject>Membrane Potentials</subject><subject>Myocardium</subject><subject>P branes</subject><subject>Papillary Muscles - physiology</subject><subject>Sodium</subject><subject>Sodium - physiology</subject><subject>String theory</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDlPwzAcxS0EKqXwDYqUiS2pjzhORlRRQCpi4FgtH_9IrnIUOxn67XGVCJb3hncMP4TWBGeE0GITjIPOQEYKlrGy4BmrxAVaElzxtKKYXaIlxqxISyz4NboJ4YBxzCq2QAsuCipEuUSbj966sU22o_fQDYnrku_o3pmxUT55O_VGeetUk-ycBh9u0VWtmgB3s6_Q1-7pc_uS7t-fX7eP-9TkpBrS2thKlEprzKLkxmprFNRQY2AlqaLpwnJqbF4TzWsFIjcMaI6ZUcQwxlboYfo9-v5nhDDI1gUDTaM66McgS04o5UUei_lUNL4PwUMtj961yp8kwfLMSc6cZOQkz5xk5BRn9_P_qFuwf6MZTMzXU34IQ-__PwXlmAr2CzszcFA</recordid><startdate>19690124</startdate><enddate>19690124</enddate><creator>Reuter, Harald</creator><creator>Beeler, George W.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19690124</creationdate><title>Sodium Current in Ventricular Myocardial Fibers</title><author>Reuter, Harald ; Beeler, George W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-fcd978abb03abb4cdbdcaefef0e3819f0eb6d52cd4f1b5fae74c3e2403ca1c333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>Depolarization</topic><topic>Dogs</topic><topic>Electric current</topic><topic>Electric potential</topic><topic>Heart</topic><topic>Heart - physiology</topic><topic>Heart Ventricles</topic><topic>In Vitro Techniques</topic><topic>Ion currents</topic><topic>Ions</topic><topic>Membrane potential</topic><topic>Membrane Potentials</topic><topic>Myocardium</topic><topic>P branes</topic><topic>Papillary Muscles - physiology</topic><topic>Sodium</topic><topic>Sodium - physiology</topic><topic>String theory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reuter, Harald</creatorcontrib><creatorcontrib>Beeler, George W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reuter, Harald</au><au>Beeler, George W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sodium Current in Ventricular Myocardial Fibers</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1969-01-24</date><risdate>1969</risdate><volume>163</volume><issue>3865</issue><spage>397</spage><epage>399</epage><pages>397-399</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Membrane currents were measured in thin bundles of dog ventricular myocardium under voltage-clamp conditions. A rather large initial inward current which had an equilibrium potential at about + 55 millivolts could be recorded. When the external sodium concentration was reduced, the equilibrium potential for this current was shifted by the amount predicted theoretically for a current carried solely by sodium ions. The size of the sodium inward current (I$_{Na}$) was largely dependent on the preceding membrane potential. The I$_{Na}$ was completely inactivated if the membrane potential was as low as - 45 millivolts. Sodium ions are the main carrier of charge during the rapid depolarization phase of the action potential.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>5762778</pmid><doi>10.1126/science.163.3865.397</doi><tpages>3</tpages></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 1969-01, Vol.163 (3865), p.397-399 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_85122564 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Action Potentials Animals Depolarization Dogs Electric current Electric potential Heart Heart - physiology Heart Ventricles In Vitro Techniques Ion currents Ions Membrane potential Membrane Potentials Myocardium P branes Papillary Muscles - physiology Sodium Sodium - physiology String theory |
| title | Sodium Current in Ventricular Myocardial Fibers |
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