ANTICOAGULANTS IN "IRREVERSIBLE" ACUTE RENAL FAILURE
6 consecutive cases of oliguric renal failure shown histologically to be due to glomerulonephritis or obstructive lesions in arterioles and glomeruli improved considerably following continuous high-dose infusion of heparin, which was given in addition to steroids and immunosuppressive drugs. The pro...
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| Veröffentlicht in: | The Lancet (British edition) 1968-01, Vol.292 (7583), p.1360-1363 |
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| container_issue | 7583 |
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| container_title | The Lancet (British edition) |
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| creator | Kincaid-Smith, Priscilla Saker, B.M. Fairley, K.F. |
| description | 6 consecutive cases of oliguric renal failure shown histologically to be due to glomerulonephritis or obstructive lesions in arterioles and glomeruli improved considerably following continuous high-dose infusion of heparin, which was given in addition to steroids and immunosuppressive drugs. The prompt improvement in renal function which followed heparin infusion suggests that this method of treatment may have some direct effect on the underlying lesion as has been demonstrated in animals. 2 patients died from diffuse vascular lesions in other organs, but 4 were well at two to nine months after the onset of the renal failure, with blood-urea levels between 23 and 40 mg. per 100 ml. |
| doi_str_mv | 10.1016/S0140-6736(68)92671-8 |
| format | Article |
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The prompt improvement in renal function which followed heparin infusion suggests that this method of treatment may have some direct effect on the underlying lesion as has been demonstrated in animals. 2 patients died from diffuse vascular lesions in other organs, but 4 were well at two to nine months after the onset of the renal failure, with blood-urea levels between 23 and 40 mg. per 100 ml.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(68)92671-8</identifier><identifier>PMID: 4177930</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acute Kidney Injury - drug therapy ; Adolescent ; Adult ; Anticoagulants - therapeutic use ; Arteritis - complications ; Creatinine - blood ; Dipyridamole - therapeutic use ; Female ; Glomerulonephritis - complications ; Glomerulonephritis - drug therapy ; Heparin - therapeutic use ; Humans ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - urine ; Kidney Function Tests ; Male ; Middle Aged ; Phenindione - therapeutic use ; Purpura, Thrombotic Thrombocytopenic - complications</subject><ispartof>The Lancet (British edition), 1968-01, Vol.292 (7583), p.1360-1363</ispartof><rights>1968</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-6e54ef95a77a5f42ea49f0ac9b95bd268b0962626ccdd4890df08548454dac33</citedby><cites>FETCH-LOGICAL-c360t-6e54ef95a77a5f42ea49f0ac9b95bd268b0962626ccdd4890df08548454dac33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0140-6736(68)92671-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4177930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kincaid-Smith, Priscilla</creatorcontrib><creatorcontrib>Saker, B.M.</creatorcontrib><creatorcontrib>Fairley, K.F.</creatorcontrib><title>ANTICOAGULANTS IN "IRREVERSIBLE" ACUTE RENAL FAILURE</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>6 consecutive cases of oliguric renal failure shown histologically to be due to glomerulonephritis or obstructive lesions in arterioles and glomeruli improved considerably following continuous high-dose infusion of heparin, which was given in addition to steroids and immunosuppressive drugs. The prompt improvement in renal function which followed heparin infusion suggests that this method of treatment may have some direct effect on the underlying lesion as has been demonstrated in animals. 2 patients died from diffuse vascular lesions in other organs, but 4 were well at two to nine months after the onset of the renal failure, with blood-urea levels between 23 and 40 mg. per 100 ml.</description><subject>Acute Kidney Injury - drug therapy</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anticoagulants - therapeutic use</subject><subject>Arteritis - complications</subject><subject>Creatinine - blood</subject><subject>Dipyridamole - therapeutic use</subject><subject>Female</subject><subject>Glomerulonephritis - complications</subject><subject>Glomerulonephritis - drug therapy</subject><subject>Heparin - therapeutic use</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - urine</subject><subject>Kidney Function Tests</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phenindione - therapeutic use</subject><subject>Purpura, Thrombotic Thrombocytopenic - complications</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRaq3-hELoQfQQnU328yQxpDUQWkhT8bZsNxuItE3NtoL_3vQDrzKHGXjfmZd5EBpieMKA2fMcMAGf8ZA9MPEoA8axLy5QHxNOfEr4xyXq_1mu0Y1znwBAGNAe6hHMuQyhj0g0LdJ4Fk0WWTfNvXTqjdI8T96TfJ6-ZsnIi-JFkXh5Mo0ybxyl2SJPbtFVpVfO3p37ABXjpIjf_Gw2SeMo803IYOczS4mtJNWca1qRwGoiK9BGLiVdlgETS5As6MqYsiRCQlmBoEQQSkptwnCA7k9nt23ztbdup9a1M3a10hvb7J0SFDglcDDSk9G0jXOtrdS2rde6_VEY1AGWOsJSBxKKCXWEpUS3NzwH7JdrW_5tnel0-stJt92T37VtlTO13Rhb1q01O1U29T8JvzllcyI</recordid><startdate>19680101</startdate><enddate>19680101</enddate><creator>Kincaid-Smith, Priscilla</creator><creator>Saker, B.M.</creator><creator>Fairley, K.F.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19680101</creationdate><title>ANTICOAGULANTS IN "IRREVERSIBLE" ACUTE RENAL FAILURE</title><author>Kincaid-Smith, Priscilla ; Saker, B.M. ; Fairley, K.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-6e54ef95a77a5f42ea49f0ac9b95bd268b0962626ccdd4890df08548454dac33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Acute Kidney Injury - drug therapy</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Anticoagulants - therapeutic use</topic><topic>Arteritis - complications</topic><topic>Creatinine - blood</topic><topic>Dipyridamole - therapeutic use</topic><topic>Female</topic><topic>Glomerulonephritis - complications</topic><topic>Glomerulonephritis - drug therapy</topic><topic>Heparin - therapeutic use</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - urine</topic><topic>Kidney Function Tests</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phenindione - therapeutic use</topic><topic>Purpura, Thrombotic Thrombocytopenic - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kincaid-Smith, Priscilla</creatorcontrib><creatorcontrib>Saker, B.M.</creatorcontrib><creatorcontrib>Fairley, K.F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kincaid-Smith, Priscilla</au><au>Saker, B.M.</au><au>Fairley, K.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ANTICOAGULANTS IN "IRREVERSIBLE" ACUTE RENAL FAILURE</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1968-01-01</date><risdate>1968</risdate><volume>292</volume><issue>7583</issue><spage>1360</spage><epage>1363</epage><pages>1360-1363</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><abstract>6 consecutive cases of oliguric renal failure shown histologically to be due to glomerulonephritis or obstructive lesions in arterioles and glomeruli improved considerably following continuous high-dose infusion of heparin, which was given in addition to steroids and immunosuppressive drugs. The prompt improvement in renal function which followed heparin infusion suggests that this method of treatment may have some direct effect on the underlying lesion as has been demonstrated in animals. 2 patients died from diffuse vascular lesions in other organs, but 4 were well at two to nine months after the onset of the renal failure, with blood-urea levels between 23 and 40 mg. per 100 ml.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>4177930</pmid><doi>10.1016/S0140-6736(68)92671-8</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1968-01, Vol.292 (7583), p.1360-1363 |
| issn | 0140-6736 1474-547X |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Acute Kidney Injury - drug therapy Adolescent Adult Anticoagulants - therapeutic use Arteritis - complications Creatinine - blood Dipyridamole - therapeutic use Female Glomerulonephritis - complications Glomerulonephritis - drug therapy Heparin - therapeutic use Humans Kidney Failure, Chronic - etiology Kidney Failure, Chronic - urine Kidney Function Tests Male Middle Aged Phenindione - therapeutic use Purpura, Thrombotic Thrombocytopenic - complications |
| title | ANTICOAGULANTS IN "IRREVERSIBLE" ACUTE RENAL FAILURE |
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