Fetal liver iron overload: the role of MR imaging
Objective To assess the potential role of MR imaging in the diagnosis of fetal liver iron overload. Methods We reviewed seven cases of abnormal liver signal in fetuses referred to MR imaging in a context of suspected congenital infection ( n = 2), digestive tract anomalies ( n = 3) and hydrops fet...
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| Veröffentlicht in: | European radiology 2011-02, Vol.21 (2), p.295-300 |
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| creator | Cassart, Marie Avni, Freddy Efraim Guibaud, Laurent Molho, Marc D’Haene, Nicky Paupe, Alain |
| description | Objective
To assess the potential role of MR imaging in the diagnosis of fetal liver iron overload.
Methods
We reviewed seven cases of abnormal liver signal in fetuses referred to MR imaging in a context of suspected congenital infection (
n
= 2), digestive tract anomalies (
n
= 3) and hydrops fetalis (
n
= 2). The average GA of the fetuses was 31 weeks. The antenatal diagnoses were compared with histological data (
n
= 6) and postnatal work-up (
n
= 1).
Results
Magnetic resonance imaging demonstrated unexpected abnormal fetal liver signal suggestive of iron overload in all cases. The iron overload was confirmed on postnatal biopsy (
n
= 2) and fetopathology (
n
= 4). The final diagnosis was hepatic hemosiderosis (haemolytic anaemia (
n
= 2) and syndromal anomalies (
n
= 2)) and congenital haemochromatosis (
n
= 3). In all cases, the liver appeared normal on US.
Conclusions
Magnetic resonance is the only imaging technique able to demonstrate liver iron overload in utero. Yet, the study outlines the fundamental role of MR imaging in cases of congenital haemochromatosis. The antenatal diagnosis of such a condition may prompt ante—(in the case of recurrence) or neonatal treatment, which might improve the prognosis. |
| doi_str_mv | 10.1007/s00330-010-1920-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_850564052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>850564052</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-79d03a3cfd1511dd12cf63a6f2ff65f1f5b44b8326d0b8973a23be7f9a4efa0a3</originalsourceid><addsrcrecordid>eNp1kFFLwzAQx4Mobk4_gC9SfPGpepekaeObDKfCRBB9DmmbzI6umUkr-O3N2FQQfLo77nf_u_sTcopwiQD5VQBgDFJASFFSSMUeGSNnNEUo-D4Zg2RFmkvJR-QohCUASOT5IRlRKCgC8jHBmel1m7TNh_FJ412XuJi1TtfXSf9mEu9akzibPD4nzUovmm5xTA6sboM52cUJeZ3dvkzv0_nT3cP0Zp5WLIc-rq2BaVbZGjPEukZaWcG0sNRakVm0Wcl5WTAqaigLmTNNWWlyKzU3VoNmE3Kx1V179z6Y0KtVEyrTtrozbgiqyCATHDIayfM_5NINvovHqYJLQVnGZIRwC1XeheCNVWsfP_KfCkFt3FRbNxVs6uimEnHmbCc8lCtT_0x82xcBugVCbHUL4383_6_6BcNqfRw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>849623539</pqid></control><display><type>article</type><title>Fetal liver iron overload: the role of MR imaging</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Cassart, Marie ; Avni, Freddy Efraim ; Guibaud, Laurent ; Molho, Marc ; D’Haene, Nicky ; Paupe, Alain</creator><creatorcontrib>Cassart, Marie ; Avni, Freddy Efraim ; Guibaud, Laurent ; Molho, Marc ; D’Haene, Nicky ; Paupe, Alain</creatorcontrib><description>Objective
To assess the potential role of MR imaging in the diagnosis of fetal liver iron overload.
Methods
We reviewed seven cases of abnormal liver signal in fetuses referred to MR imaging in a context of suspected congenital infection (
n
= 2), digestive tract anomalies (
n
= 3) and hydrops fetalis (
n
= 2). The average GA of the fetuses was 31 weeks. The antenatal diagnoses were compared with histological data (
n
= 6) and postnatal work-up (
n
= 1).
Results
Magnetic resonance imaging demonstrated unexpected abnormal fetal liver signal suggestive of iron overload in all cases. The iron overload was confirmed on postnatal biopsy (
n
= 2) and fetopathology (
n
= 4). The final diagnosis was hepatic hemosiderosis (haemolytic anaemia (
n
= 2) and syndromal anomalies (
n
= 2)) and congenital haemochromatosis (
n
= 3). In all cases, the liver appeared normal on US.
Conclusions
Magnetic resonance is the only imaging technique able to demonstrate liver iron overload in utero. Yet, the study outlines the fundamental role of MR imaging in cases of congenital haemochromatosis. The antenatal diagnosis of such a condition may prompt ante—(in the case of recurrence) or neonatal treatment, which might improve the prognosis.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-010-1920-6</identifier><identifier>PMID: 20821014</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Abdomen ; Anemia ; Biopsy ; Diagnostic Radiology ; Esophagus ; Female ; Fetal Diseases - diagnosis ; Fetuses ; Histology ; Humans ; Imaging ; Infections ; Internal Medicine ; Interventional Radiology ; Iron ; Iron Overload - diagnosis ; Liver ; Magnetic Resonance ; Magnetic resonance imaging ; Male ; Medicine ; Medicine & Public Health ; Neuroradiology ; Peritonitis ; Prenatal Diagnosis - methods ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Ultrasonic imaging ; Ultrasound</subject><ispartof>European radiology, 2011-02, Vol.21 (2), p.295-300</ispartof><rights>European Society of Radiology 2010</rights><rights>European Society of Radiology 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-79d03a3cfd1511dd12cf63a6f2ff65f1f5b44b8326d0b8973a23be7f9a4efa0a3</citedby><cites>FETCH-LOGICAL-c370t-79d03a3cfd1511dd12cf63a6f2ff65f1f5b44b8326d0b8973a23be7f9a4efa0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-010-1920-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-010-1920-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20821014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cassart, Marie</creatorcontrib><creatorcontrib>Avni, Freddy Efraim</creatorcontrib><creatorcontrib>Guibaud, Laurent</creatorcontrib><creatorcontrib>Molho, Marc</creatorcontrib><creatorcontrib>D’Haene, Nicky</creatorcontrib><creatorcontrib>Paupe, Alain</creatorcontrib><title>Fetal liver iron overload: the role of MR imaging</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective
To assess the potential role of MR imaging in the diagnosis of fetal liver iron overload.
Methods
We reviewed seven cases of abnormal liver signal in fetuses referred to MR imaging in a context of suspected congenital infection (
n
= 2), digestive tract anomalies (
n
= 3) and hydrops fetalis (
n
= 2). The average GA of the fetuses was 31 weeks. The antenatal diagnoses were compared with histological data (
n
= 6) and postnatal work-up (
n
= 1).
Results
Magnetic resonance imaging demonstrated unexpected abnormal fetal liver signal suggestive of iron overload in all cases. The iron overload was confirmed on postnatal biopsy (
n
= 2) and fetopathology (
n
= 4). The final diagnosis was hepatic hemosiderosis (haemolytic anaemia (
n
= 2) and syndromal anomalies (
n
= 2)) and congenital haemochromatosis (
n
= 3). In all cases, the liver appeared normal on US.
Conclusions
Magnetic resonance is the only imaging technique able to demonstrate liver iron overload in utero. Yet, the study outlines the fundamental role of MR imaging in cases of congenital haemochromatosis. The antenatal diagnosis of such a condition may prompt ante—(in the case of recurrence) or neonatal treatment, which might improve the prognosis.</description><subject>Abdomen</subject><subject>Anemia</subject><subject>Biopsy</subject><subject>Diagnostic Radiology</subject><subject>Esophagus</subject><subject>Female</subject><subject>Fetal Diseases - diagnosis</subject><subject>Fetuses</subject><subject>Histology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Iron</subject><subject>Iron Overload - diagnosis</subject><subject>Liver</subject><subject>Magnetic Resonance</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroradiology</subject><subject>Peritonitis</subject><subject>Prenatal Diagnosis - methods</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kFFLwzAQx4Mobk4_gC9SfPGpepekaeObDKfCRBB9DmmbzI6umUkr-O3N2FQQfLo77nf_u_sTcopwiQD5VQBgDFJASFFSSMUeGSNnNEUo-D4Zg2RFmkvJR-QohCUASOT5IRlRKCgC8jHBmel1m7TNh_FJ412XuJi1TtfXSf9mEu9akzibPD4nzUovmm5xTA6sboM52cUJeZ3dvkzv0_nT3cP0Zp5WLIc-rq2BaVbZGjPEukZaWcG0sNRakVm0Wcl5WTAqaigLmTNNWWlyKzU3VoNmE3Kx1V179z6Y0KtVEyrTtrozbgiqyCATHDIayfM_5NINvovHqYJLQVnGZIRwC1XeheCNVWsfP_KfCkFt3FRbNxVs6uimEnHmbCc8lCtT_0x82xcBugVCbHUL4383_6_6BcNqfRw</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Cassart, Marie</creator><creator>Avni, Freddy Efraim</creator><creator>Guibaud, Laurent</creator><creator>Molho, Marc</creator><creator>D’Haene, Nicky</creator><creator>Paupe, Alain</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Fetal liver iron overload: the role of MR imaging</title><author>Cassart, Marie ; Avni, Freddy Efraim ; Guibaud, Laurent ; Molho, Marc ; D’Haene, Nicky ; Paupe, Alain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-79d03a3cfd1511dd12cf63a6f2ff65f1f5b44b8326d0b8973a23be7f9a4efa0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdomen</topic><topic>Anemia</topic><topic>Biopsy</topic><topic>Diagnostic Radiology</topic><topic>Esophagus</topic><topic>Female</topic><topic>Fetal Diseases - diagnosis</topic><topic>Fetuses</topic><topic>Histology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Infections</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Iron</topic><topic>Iron Overload - diagnosis</topic><topic>Liver</topic><topic>Magnetic Resonance</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroradiology</topic><topic>Peritonitis</topic><topic>Prenatal Diagnosis - methods</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cassart, Marie</creatorcontrib><creatorcontrib>Avni, Freddy Efraim</creatorcontrib><creatorcontrib>Guibaud, Laurent</creatorcontrib><creatorcontrib>Molho, Marc</creatorcontrib><creatorcontrib>D’Haene, Nicky</creatorcontrib><creatorcontrib>Paupe, Alain</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cassart, Marie</au><au>Avni, Freddy Efraim</au><au>Guibaud, Laurent</au><au>Molho, Marc</au><au>D’Haene, Nicky</au><au>Paupe, Alain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal liver iron overload: the role of MR imaging</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>21</volume><issue>2</issue><spage>295</spage><epage>300</epage><pages>295-300</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective
To assess the potential role of MR imaging in the diagnosis of fetal liver iron overload.
Methods
We reviewed seven cases of abnormal liver signal in fetuses referred to MR imaging in a context of suspected congenital infection (
n
= 2), digestive tract anomalies (
n
= 3) and hydrops fetalis (
n
= 2). The average GA of the fetuses was 31 weeks. The antenatal diagnoses were compared with histological data (
n
= 6) and postnatal work-up (
n
= 1).
Results
Magnetic resonance imaging demonstrated unexpected abnormal fetal liver signal suggestive of iron overload in all cases. The iron overload was confirmed on postnatal biopsy (
n
= 2) and fetopathology (
n
= 4). The final diagnosis was hepatic hemosiderosis (haemolytic anaemia (
n
= 2) and syndromal anomalies (
n
= 2)) and congenital haemochromatosis (
n
= 3). In all cases, the liver appeared normal on US.
Conclusions
Magnetic resonance is the only imaging technique able to demonstrate liver iron overload in utero. Yet, the study outlines the fundamental role of MR imaging in cases of congenital haemochromatosis. The antenatal diagnosis of such a condition may prompt ante—(in the case of recurrence) or neonatal treatment, which might improve the prognosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20821014</pmid><doi>10.1007/s00330-010-1920-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2011-02, Vol.21 (2), p.295-300 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_850564052 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abdomen Anemia Biopsy Diagnostic Radiology Esophagus Female Fetal Diseases - diagnosis Fetuses Histology Humans Imaging Infections Internal Medicine Interventional Radiology Iron Iron Overload - diagnosis Liver Magnetic Resonance Magnetic resonance imaging Male Medicine Medicine & Public Health Neuroradiology Peritonitis Prenatal Diagnosis - methods Radiology Reproducibility of Results Sensitivity and Specificity Ultrasonic imaging Ultrasound |
| title | Fetal liver iron overload: the role of MR imaging |
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