Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes [corrected]

Accumulation of pro-nerve growth factor (NGF), the pro form of NGF, has been detected in neurodegenerative diseases. However, the role of proNGF in the diabetic retina and the molecular mechanisms by which proNGF causes retinal neurodegeneration remain unknown. The aim of this study was to elucidate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Diabetologia 2011-03, Vol.54 (3), p.669-680
Hauptverfasser:	Al-Gayyar, M M H, Matragoon, S, Pillai, B A, Ali, T K, Abdelsaid, M A, El-Remessy, A B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - drug effects Blotting, Western Body Weight - drug effects Catechin - pharmacology Cell Line In Situ Nick-End Labeling Male Nerve Degeneration - metabolism Nerve Degeneration - prevention & control Nerve Growth Factor - metabolism Rats Rats, Sprague-Dawley Receptor, Nerve Growth Factor - metabolism Retina - drug effects Retina - metabolism Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism RNA, Small Interfering - genetics Tyrosine - analogs & derivatives Tyrosine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!