A dystrophy-like myopathy in thyroidectomized rabbits
The histopathological and enzyme histochemical changes in the muscles of thyroidectomized rabbits are described. Between 4 and 18 months after thyroidectomy, the muscles were found to show changes reminiscent of muscular dystrophy, e.g. marked variation in fibre diameter, rounding of fibres, central...
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| Veröffentlicht in: | Journal of the neurological sciences 1968-03, Vol.6 (2), p.301-314 |
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| container_title | Journal of the neurological sciences |
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| creator | Den Hartog Jager, W.A. Meijer, A.E.F.H. de Jong, J.M.B.V. |
| description | The histopathological and enzyme histochemical changes in the muscles of thyroidectomized rabbits are described.
Between 4 and 18 months after thyroidectomy, the muscles were found to show changes reminiscent of muscular dystrophy,
e.g. marked variation in fibre diameter, rounding of fibres, central migration of nuclei, vesicular nuclei with prominent nucleoli, sarcoplasmic masses and, in the later stages, a marked increase in connective tissue and a moderate increase in adipose tissue. Enzyme histochemical changes were also significant, both with oxidative and with glycogenolytic enzymes.
Sarcoplasmic masses have been produced experimentally in the muscles of thyroidectomized rabbits. |
| doi_str_mv | 10.1016/0022-510X(68)90098-1 |
| format | Article |
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Between 4 and 18 months after thyroidectomy, the muscles were found to show changes reminiscent of muscular dystrophy,
e.g. marked variation in fibre diameter, rounding of fibres, central migration of nuclei, vesicular nuclei with prominent nucleoli, sarcoplasmic masses and, in the later stages, a marked increase in connective tissue and a moderate increase in adipose tissue. Enzyme histochemical changes were also significant, both with oxidative and with glycogenolytic enzymes.
Sarcoplasmic masses have been produced experimentally in the muscles of thyroidectomized rabbits.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(68)90098-1</identifier><identifier>PMID: 4179112</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adenosine Triphosphatases ; Animals ; Cell Nucleus ; Glucosyltransferases - analysis ; Glycerolphosphate Dehydrogenase - analysis ; Glycogen ; Histocytochemistry ; L-Lactate Dehydrogenase - analysis ; Mitochondria, Muscle - enzymology ; Muscles - enzymology ; Muscles - pathology ; Muscular Diseases - pathology ; Muscular Dystrophies - pathology ; Myofibrils - enzymology ; NAD ; NADP ; Oxidoreductases - analysis ; Rabbits ; Staining and Labeling ; Succinate Dehydrogenase - analysis ; Thyroid Gland - physiopathology ; Thyroidectomy</subject><ispartof>Journal of the neurological sciences, 1968-03, Vol.6 (2), p.301-314</ispartof><rights>1968</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-4d0e2252fd89cb82d38e15d759b0a21e4a4a1be19f6bc9f4f7bd9d678f6937cb3</citedby><cites>FETCH-LOGICAL-c357t-4d0e2252fd89cb82d38e15d759b0a21e4a4a1be19f6bc9f4f7bd9d678f6937cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-510X(68)90098-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4179112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Den Hartog Jager, W.A.</creatorcontrib><creatorcontrib>Meijer, A.E.F.H.</creatorcontrib><creatorcontrib>de Jong, J.M.B.V.</creatorcontrib><title>A dystrophy-like myopathy in thyroidectomized rabbits</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>The histopathological and enzyme histochemical changes in the muscles of thyroidectomized rabbits are described.
Between 4 and 18 months after thyroidectomy, the muscles were found to show changes reminiscent of muscular dystrophy,
e.g. marked variation in fibre diameter, rounding of fibres, central migration of nuclei, vesicular nuclei with prominent nucleoli, sarcoplasmic masses and, in the later stages, a marked increase in connective tissue and a moderate increase in adipose tissue. Enzyme histochemical changes were also significant, both with oxidative and with glycogenolytic enzymes.
Sarcoplasmic masses have been produced experimentally in the muscles of thyroidectomized rabbits.</description><subject>Adenosine Triphosphatases</subject><subject>Animals</subject><subject>Cell Nucleus</subject><subject>Glucosyltransferases - analysis</subject><subject>Glycerolphosphate Dehydrogenase - analysis</subject><subject>Glycogen</subject><subject>Histocytochemistry</subject><subject>L-Lactate Dehydrogenase - analysis</subject><subject>Mitochondria, Muscle - enzymology</subject><subject>Muscles - enzymology</subject><subject>Muscles - pathology</subject><subject>Muscular Diseases - pathology</subject><subject>Muscular Dystrophies - pathology</subject><subject>Myofibrils - enzymology</subject><subject>NAD</subject><subject>NADP</subject><subject>Oxidoreductases - analysis</subject><subject>Rabbits</subject><subject>Staining and Labeling</subject><subject>Succinate Dehydrogenase - analysis</subject><subject>Thyroid Gland - physiopathology</subject><subject>Thyroidectomy</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LwzAYx4Moc06_gUJPoodqkjZtchHG8A0GXhS8hbw8ZdF2qUkr1E9v58aOnp7D_-Xh_0PonOAbgklxizGlKSP4_arg1wJjwVNygKaElzxlnGeHaLq3HKOTGD8wxgXnYoImOSkFIXSK2DyxQ-yCb1dDWrtPSJrBt6pbDYlbJ-MJ3lkwnW_cD9gkKK1dF0_RUaXqCGe7O0NvD_evi6d0-fL4vJgvU5Oxsktzi4FSRivLhdGc2owDYbZkQmNFCeQqV0QDEVWhjajyqtRW2KLkVSGy0uhshi63vW3wXz3ETjYuGqhrtQbfR8kZZtm4fDTmW6MJPsYAlWyDa1QYJMFyQ0tuUMgNCllw-UdLkjF2sevvdQN2H9rhGfW7rQ7jyG8HQUbjYG3AujBCkda7_x_8Ah6Nebk</recordid><startdate>196803</startdate><enddate>196803</enddate><creator>Den Hartog Jager, W.A.</creator><creator>Meijer, A.E.F.H.</creator><creator>de Jong, J.M.B.V.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196803</creationdate><title>A dystrophy-like myopathy in thyroidectomized rabbits</title><author>Den Hartog Jager, W.A. ; Meijer, A.E.F.H. ; de Jong, J.M.B.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-4d0e2252fd89cb82d38e15d759b0a21e4a4a1be19f6bc9f4f7bd9d678f6937cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Adenosine Triphosphatases</topic><topic>Animals</topic><topic>Cell Nucleus</topic><topic>Glucosyltransferases - analysis</topic><topic>Glycerolphosphate Dehydrogenase - analysis</topic><topic>Glycogen</topic><topic>Histocytochemistry</topic><topic>L-Lactate Dehydrogenase - analysis</topic><topic>Mitochondria, Muscle - enzymology</topic><topic>Muscles - enzymology</topic><topic>Muscles - pathology</topic><topic>Muscular Diseases - pathology</topic><topic>Muscular Dystrophies - pathology</topic><topic>Myofibrils - enzymology</topic><topic>NAD</topic><topic>NADP</topic><topic>Oxidoreductases - analysis</topic><topic>Rabbits</topic><topic>Staining and Labeling</topic><topic>Succinate Dehydrogenase - analysis</topic><topic>Thyroid Gland - physiopathology</topic><topic>Thyroidectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Den Hartog Jager, W.A.</creatorcontrib><creatorcontrib>Meijer, A.E.F.H.</creatorcontrib><creatorcontrib>de Jong, J.M.B.V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Den Hartog Jager, W.A.</au><au>Meijer, A.E.F.H.</au><au>de Jong, J.M.B.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A dystrophy-like myopathy in thyroidectomized rabbits</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1968-03</date><risdate>1968</risdate><volume>6</volume><issue>2</issue><spage>301</spage><epage>314</epage><pages>301-314</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>The histopathological and enzyme histochemical changes in the muscles of thyroidectomized rabbits are described.
Between 4 and 18 months after thyroidectomy, the muscles were found to show changes reminiscent of muscular dystrophy,
e.g. marked variation in fibre diameter, rounding of fibres, central migration of nuclei, vesicular nuclei with prominent nucleoli, sarcoplasmic masses and, in the later stages, a marked increase in connective tissue and a moderate increase in adipose tissue. Enzyme histochemical changes were also significant, both with oxidative and with glycogenolytic enzymes.
Sarcoplasmic masses have been produced experimentally in the muscles of thyroidectomized rabbits.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>4179112</pmid><doi>10.1016/0022-510X(68)90098-1</doi><tpages>14</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 1968-03, Vol.6 (2), p.301-314 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenosine Triphosphatases Animals Cell Nucleus Glucosyltransferases - analysis Glycerolphosphate Dehydrogenase - analysis Glycogen Histocytochemistry L-Lactate Dehydrogenase - analysis Mitochondria, Muscle - enzymology Muscles - enzymology Muscles - pathology Muscular Diseases - pathology Muscular Dystrophies - pathology Myofibrils - enzymology NAD NADP Oxidoreductases - analysis Rabbits Staining and Labeling Succinate Dehydrogenase - analysis Thyroid Gland - physiopathology Thyroidectomy |
| title | A dystrophy-like myopathy in thyroidectomized rabbits |
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