Chronic Granulocytic Leukaemia: Demonstration of the Philadelphia Chromosome in Cultures of Spleen Cells

Chronic Granulocytic Leukaemia: Demonstration of the Philadelphia Chromosome in Cultures of Spleen Cells

AN abnormal marker chromosome in chronic granulo-cytic leukaemia was described by No well and Hunger ford 1,2 and its occurrence widely confirmed 3–7 . This marker, the Philadelphia chromosome (Ph 1 ), occurs in almost all typical cases of chronic granulocytic leukaemia and appears to be an acquired...

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Veröffentlicht in:Nature (London) 1965-10, Vol.208 (5009), p.497-497
Hauptverfasser: SPIERS, A. S. D, BAIKIE, A. G
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Chromosomes
Culture Techniques
Female
Humanities and Social Sciences
Humans
letter
Leukemia, Myeloid
multidisciplinary
Science
Science (multidisciplinary)
Spleen - cytology
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Beschreibung
Zusammenfassung:AN abnormal marker chromosome in chronic granulo-cytic leukaemia was described by No well and Hunger ford 1,2 and its occurrence widely confirmed 3–7 . This marker, the Philadelphia chromosome (Ph 1 ), occurs in almost all typical cases of chronic granulocytic leukaemia and appears to be an acquired abnormality specific for the disease. The Ph 1 is derived from a chromosome of pair 21 by loss of a variable proportion of the long arms.
ISSN:0028-0836
1476-4687
DOI:10.1038/208497a0