VARIABLE DRUG SENSITIVITY AND CHROMOSOMAL FEATURES OF A CANCER CLONE
Population analysis was made of a cancer clone derived from a single tumor cell, using a clonal strain of the rat ascites hepatoma, CL-1-AH-66F. The sensitivity to nitrogen mustard N-oxide and chromosomal constitution were studied, after establishing subclonal tumors from the original clone. The res...
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| Veröffentlicht in: | GANN Japanese Journal of Cancer Research 1965/10/31, Vol.56(5), pp.443-460_2 |
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| container_title | GANN Japanese Journal of Cancer Research |
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| creator | ISAKA, Hidehiko |
| description | Population analysis was made of a cancer clone derived from a single tumor cell, using a clonal strain of the rat ascites hepatoma, CL-1-AH-66F. The sensitivity to nitrogen mustard N-oxide and chromosomal constitution were studied, after establishing subclonal tumors from the original clone. The results indicated the following facts: 1) The cancer clone is not a uniform but a complex population of cells with different degree of sensitivity to chemicals. 2) The degree of drug sensitivity, either of the original clone or its subclones, fluctuates spontaneously within a certain range during serial animal passage. 3) No specific correlation is found between the degree of drug sensitivity and chromosomal constitution of the subclonal tumors. 4) Transient change in the modal chromosome number and ploidy shift occurred during animal passage. |
| doi_str_mv | 10.20772/cancersci1959.56.5_443 |
| format | Article |
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The sensitivity to nitrogen mustard N-oxide and chromosomal constitution were studied, after establishing subclonal tumors from the original clone. The results indicated the following facts: 1) The cancer clone is not a uniform but a complex population of cells with different degree of sensitivity to chemicals. 2) The degree of drug sensitivity, either of the original clone or its subclones, fluctuates spontaneously within a certain range during serial animal passage. 3) No specific correlation is found between the degree of drug sensitivity and chromosomal constitution of the subclonal tumors. 4) Transient change in the modal chromosome number and ploidy shift occurred during animal passage.</description><identifier>ISSN: 0016-450X</identifier><identifier>DOI: 10.20772/cancersci1959.56.5_443</identifier><identifier>PMID: 4285078</identifier><language>eng</language><publisher>Japan: The Japanese Cancer Association</publisher><subject>Animals ; Carcinoma, Hepatocellular ; Chromosomes ; Liver Neoplasms ; Neoplasms, Experimental ; Nitrogen Mustard Compounds - pharmacology ; Rats</subject><ispartof>GANN Japanese Journal of Cancer Research, 1965/10/31, Vol.56(5), pp.443-460_2</ispartof><rights>The Japanese Cancer Association</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4285078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ISAKA, Hidehiko</creatorcontrib><title>VARIABLE DRUG SENSITIVITY AND CHROMOSOMAL FEATURES OF A CANCER CLONE</title><title>GANN Japanese Journal of Cancer Research</title><addtitle>GANN Japanese Journal of Cancer Research</addtitle><description>Population analysis was made of a cancer clone derived from a single tumor cell, using a clonal strain of the rat ascites hepatoma, CL-1-AH-66F. 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| ispartof | GANN Japanese Journal of Cancer Research, 1965/10/31, Vol.56(5), pp.443-460_2 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Carcinoma, Hepatocellular Chromosomes Liver Neoplasms Neoplasms, Experimental Nitrogen Mustard Compounds - pharmacology Rats |
| title | VARIABLE DRUG SENSITIVITY AND CHROMOSOMAL FEATURES OF A CANCER CLONE |
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