Effect of Hexamethonium Chloride on the Ciliary and Contractile Systems of the Ciliate Spirostomum

SYNOPSIS. The effect of hexamethonium chloride, an acetyl‐choline competitor, on the ciliary and myonemal systems of Spirostomum intermedium and S. ambiguum was investigated. Although the drug caused immobilization of the cilia, severe cell damage often ensued indicating an unspecific action. The ge...

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Veröffentlicht in:	The Journal of Protozoology 1965-08, Vol.12 (3), p.340-342
Hauptverfasser:	JONES, ALICK R., JAHN, THEODORE L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ciliophora - drug effects Hexamethonium Compounds - pharmacology In Vitro Techniques
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container_title	The Journal of Protozoology
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creator	JONES, ALICK R. JAHN, THEODORE L.
description	SYNOPSIS. The effect of hexamethonium chloride, an acetyl‐choline competitor, on the ciliary and myonemal systems of Spirostomum intermedium and S. ambiguum was investigated. Although the drug caused immobilization of the cilia, severe cell damage often ensued indicating an unspecific action. The general reaction was usually more severe and the ciliary inhibition less in S. ambiguum than in S. intermedium. It is postulated that the general reaction is the result of either membrane depolarization or binding of hexamethonium at the surface. Fed animals were more susceptible to drug action than starved ones. Raising the external potassium level did not affect the drug action.
doi_str_mv	10.1111/j.1550-7408.1965.tb03224.x
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The effect of hexamethonium chloride, an acetyl‐choline competitor, on the ciliary and myonemal systems of Spirostomum intermedium and S. ambiguum was investigated. Although the drug caused immobilization of the cilia, severe cell damage often ensued indicating an unspecific action. The general reaction was usually more severe and the ciliary inhibition less in S. ambiguum than in S. intermedium. It is postulated that the general reaction is the result of either membrane depolarization or binding of hexamethonium at the surface. Fed animals were more susceptible to drug action than starved ones. 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The effect of hexamethonium chloride, an acetyl‐choline competitor, on the ciliary and myonemal systems of Spirostomum intermedium and S. ambiguum was investigated. Although the drug caused immobilization of the cilia, severe cell damage often ensued indicating an unspecific action. The general reaction was usually more severe and the ciliary inhibition less in S. ambiguum than in S. intermedium. It is postulated that the general reaction is the result of either membrane depolarization or binding of hexamethonium at the surface. Fed animals were more susceptible to drug action than starved ones. 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The effect of hexamethonium chloride, an acetyl‐choline competitor, on the ciliary and myonemal systems of Spirostomum intermedium and S. ambiguum was investigated. Although the drug caused immobilization of the cilia, severe cell damage often ensued indicating an unspecific action. The general reaction was usually more severe and the ciliary inhibition less in S. ambiguum than in S. intermedium. It is postulated that the general reaction is the result of either membrane depolarization or binding of hexamethonium at the surface. Fed animals were more susceptible to drug action than starved ones. Raising the external potassium level did not affect the drug action.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>4955452</pmid><doi>10.1111/j.1550-7408.1965.tb03224.x</doi><tpages>3</tpages></addata></record>
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subjects	Ciliophora - drug effects Hexamethonium Compounds - pharmacology In Vitro Techniques
title	Effect of Hexamethonium Chloride on the Ciliary and Contractile Systems of the Ciliate Spirostomum
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