Inhibition of human leukocyte pyrimidine deoxynucleoside synthesis by allopurinol and 6-mercaptopurine

Allopurinol and 6-mercaptopurine, two clinically useful purine antagonists, are inhibitors of deoxythymidine phosphorylase and pyrimidine deoxyribosyltransferase from human leukocytes. The inhibition of these enzyme activities is only in the direction of nucleoside synthesis and is not competitive w...

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Veröffentlicht in:	Biochemical pharmacology 1968-10, Vol.17 (10), p.2185-2191
Hauptverfasser:	Gallo, Robert C., Perry, Seymour, Breitman, T.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopurinol - pharmacology Deoxyuridine - biosynthesis Depression, Chemical Humans Kinetics Leukocytes - enzymology Leukocytes - metabolism Mercaptopurine - pharmacology Nucleosides - biosynthesis Nucleosides - metabolism Pentosephosphates Pyridines - metabolism Pyrimidines - biosynthesis Thymine Transferases - antagonists & inhibitors Transferases - metabolism Uridine - biosynthesis
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