Inhibition of human leukocyte pyrimidine deoxynucleoside synthesis by allopurinol and 6-mercaptopurine
Allopurinol and 6-mercaptopurine, two clinically useful purine antagonists, are inhibitors of deoxythymidine phosphorylase and pyrimidine deoxyribosyltransferase from human leukocytes. The inhibition of these enzyme activities is only in the direction of nucleoside synthesis and is not competitive w...
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| Veröffentlicht in: | Biochemical pharmacology 1968-10, Vol.17 (10), p.2185-2191 |
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| container_end_page | 2191 |
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| container_title | Biochemical pharmacology |
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| creator | Gallo, Robert C. Perry, Seymour Breitman, T.R. |
| description | Allopurinol and 6-mercaptopurine, two clinically useful purine antagonists, are inhibitors of deoxythymidine phosphorylase and pyrimidine deoxyribosyltransferase from human leukocytes. The inhibition of these enzyme activities is only in the direction of nucleoside synthesis and is not competitive with either substrate (thymine or deoxyribose-1-phosphate). 6-Mercaptopurine, but not allopurinol, also inhibits uridine phosphorylase. |
| doi_str_mv | 10.1016/0006-2952(68)90193-7 |
| format | Article |
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The inhibition of these enzyme activities is only in the direction of nucleoside synthesis and is not competitive with either substrate (thymine or deoxyribose-1-phosphate). 6-Mercaptopurine, but not allopurinol, also inhibits uridine phosphorylase.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(68)90193-7</identifier><identifier>PMID: 5696884</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Allopurinol - pharmacology ; Deoxyuridine - biosynthesis ; Depression, Chemical ; Humans ; Kinetics ; Leukocytes - enzymology ; Leukocytes - metabolism ; Mercaptopurine - pharmacology ; Nucleosides - biosynthesis ; Nucleosides - metabolism ; Pentosephosphates ; Pyridines - metabolism ; Pyrimidines - biosynthesis ; Thymine ; Transferases - antagonists & inhibitors ; Transferases - metabolism ; Uridine - biosynthesis</subject><ispartof>Biochemical pharmacology, 1968-10, Vol.17 (10), p.2185-2191</ispartof><rights>1968</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-2e8c6843d0140dbd63df9ce3e54073a97217e735f2741c58f1f18a9e04d801233</citedby><cites>FETCH-LOGICAL-c272t-2e8c6843d0140dbd63df9ce3e54073a97217e735f2741c58f1f18a9e04d801233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006295268901937$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5696884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallo, Robert C.</creatorcontrib><creatorcontrib>Perry, Seymour</creatorcontrib><creatorcontrib>Breitman, T.R.</creatorcontrib><title>Inhibition of human leukocyte pyrimidine deoxynucleoside synthesis by allopurinol and 6-mercaptopurine</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>Allopurinol and 6-mercaptopurine, two clinically useful purine antagonists, are inhibitors of deoxythymidine phosphorylase and pyrimidine deoxyribosyltransferase from human leukocytes. 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The inhibition of these enzyme activities is only in the direction of nucleoside synthesis and is not competitive with either substrate (thymine or deoxyribose-1-phosphate). 6-Mercaptopurine, but not allopurinol, also inhibits uridine phosphorylase.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>5696884</pmid><doi>10.1016/0006-2952(68)90193-7</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biochemical pharmacology, 1968-10, Vol.17 (10), p.2185-2191 |
| issn | 0006-2952 1873-2968 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allopurinol - pharmacology Deoxyuridine - biosynthesis Depression, Chemical Humans Kinetics Leukocytes - enzymology Leukocytes - metabolism Mercaptopurine - pharmacology Nucleosides - biosynthesis Nucleosides - metabolism Pentosephosphates Pyridines - metabolism Pyrimidines - biosynthesis Thymine Transferases - antagonists & inhibitors Transferases - metabolism Uridine - biosynthesis |
| title | Inhibition of human leukocyte pyrimidine deoxynucleoside synthesis by allopurinol and 6-mercaptopurine |
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