Soybean Peptide Lunasin Suppresses In Vitro and In Vivo 7,12-Dimethylbenz[a]anthracene-Induced Tumorigenesis

: Lunasin is a novel peptide identified in soybean and other seeds. This study evaluated the anti‐tumorigenic effects of lunasin on 7,12‐dimethylbenz(a)anthracene (DMBA) and 3‐methylcholanthrene‐treated (MCA) fibroblast NIH/3T3 cells. Lunasin significantly inhibited cell proliferation and cancerous...

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Veröffentlicht in:	Journal of food science 2010-11, Vol.75 (9), p.H311-H316
Hauptverfasser:	Hsieh, Chia-Chien, Hernández-Ledesma, Blanca, de Lumen, Ben O.
Format:	Artikel
Sprache:	eng
Schlagworte:	12-dimethylbenz(a)anthracene 3-methylcholanthrene 9,10-Dimethyl-1,2-benzanthracene - toxicity Animal productions Animal, plant, fungal and microbial proteins, edible seaweeds and food yeasts Animals Antineoplastic Agents, Phytogenic - pharmacology Biocompatibility Biological and medical sciences Biomedical materials Cancer cancer preventive properties Carcinogens - toxicity Cell Proliferation Diet Dietary Proteins - administration & dosage Drug Screening Assays, Antitumor Female Food industries Food science Functional foods & nutraceuticals Fundamental and applied biological sciences. Psychology Glycine max - chemistry In vivo testing In vivo tests lunasin mammary cancer Methylcholanthrene Mice Mice, Inbred SENCAR Neoplasms, Experimental - chemically induced Neoplasms, Experimental - drug therapy NIH 3T3 Cells Peptides Peptides - analysis Proteins Rodents Soy products soy protein Soybean Proteins - chemistry Soybean Proteins - pharmacology Soybeans Surgical implants Terrestrial animal productions Vertebrates
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