Soybean Peptide Lunasin Suppresses In Vitro and In Vivo 7,12-Dimethylbenz[a]anthracene-Induced Tumorigenesis
: Lunasin is a novel peptide identified in soybean and other seeds. This study evaluated the anti‐tumorigenic effects of lunasin on 7,12‐dimethylbenz(a)anthracene (DMBA) and 3‐methylcholanthrene‐treated (MCA) fibroblast NIH/3T3 cells. Lunasin significantly inhibited cell proliferation and cancerous...
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| Veröffentlicht in: | Journal of food science 2010-11, Vol.75 (9), p.H311-H316 |
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| creator | Hsieh, Chia-Chien Hernández-Ledesma, Blanca de Lumen, Ben O. |
| description | : Lunasin is a novel peptide identified in soybean and other seeds. This study evaluated the anti‐tumorigenic effects of lunasin on 7,12‐dimethylbenz(a)anthracene (DMBA) and 3‐methylcholanthrene‐treated (MCA) fibroblast NIH/3T3 cells. Lunasin significantly inhibited cell proliferation and cancerous foci formation in these 2 chemical carcinogens‐treated cells. An in vivo SENCAR mouse model induced with DMBA was used to study the mammary cancer preventive properties of dietary lunasin contained in soy protein. Tumor incidence was 67% and 50%, and the tumor generation was 1.88 ± 0.48 and 1.17 ± 0.17, respectively, for the mice fed control diet and experimental diet obtained after AIN‐93G supplementation with lunasin‐enriched soy protein concentrate (containing 0.23% lunasin). However, no effects were observed in mice fed AIN‐93G supplemented with soy protein concentrate (containing 0.15% lunasin). The data provided illustrate the anticancer potential of lunasin both in vitro and in vivo and supports the recommendation of soy protein as a dietary component that may aid in the prevention of mammary cancer.
Practical Application: Daily intake of lunasin‐enriched soy protein is introduced as a promising strategy to prevent chemical carcinogens‐induced mammary tumors. |
| doi_str_mv | 10.1111/j.1750-3841.2010.01861.x |
| format | Article |
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Practical Application: Daily intake of lunasin‐enriched soy protein is introduced as a promising strategy to prevent chemical carcinogens‐induced mammary tumors.</description><identifier>ISSN: 0022-1147</identifier><identifier>EISSN: 1750-3841</identifier><identifier>DOI: 10.1111/j.1750-3841.2010.01861.x</identifier><identifier>PMID: 21535606</identifier><identifier>CODEN: JFDSAZ</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>12-dimethylbenz(a)anthracene ; 3-methylcholanthrene ; 9,10-Dimethyl-1,2-benzanthracene - toxicity ; Animal productions ; Animal, plant, fungal and microbial proteins, edible seaweeds and food yeasts ; Animals ; Antineoplastic Agents, Phytogenic - pharmacology ; Biocompatibility ; Biological and medical sciences ; Biomedical materials ; Cancer ; cancer preventive properties ; Carcinogens - toxicity ; Cell Proliferation ; Diet ; Dietary Proteins - administration & dosage ; Drug Screening Assays, Antitumor ; Female ; Food industries ; Food science ; Functional foods & nutraceuticals ; Fundamental and applied biological sciences. Psychology ; Glycine max - chemistry ; In vivo testing ; In vivo tests ; lunasin ; mammary cancer ; Methylcholanthrene ; Mice ; Mice, Inbred SENCAR ; Neoplasms, Experimental - chemically induced ; Neoplasms, Experimental - drug therapy ; NIH 3T3 Cells ; Peptides ; Peptides - analysis ; Proteins ; Rodents ; Soy products ; soy protein ; Soybean Proteins - chemistry ; Soybean Proteins - pharmacology ; Soybeans ; Surgical implants ; Terrestrial animal productions ; Vertebrates</subject><ispartof>Journal of food science, 2010-11, Vol.75 (9), p.H311-H316</ispartof><rights>2010 Institute of Food Technologists</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Institute of Food Technologists Nov/Dec 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5621-c032f0d18f5b78cbc3b47142bd25be055a70e57667bb6ab5bce3308f1268d6f93</citedby><cites>FETCH-LOGICAL-c5621-c032f0d18f5b78cbc3b47142bd25be055a70e57667bb6ab5bce3308f1268d6f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1750-3841.2010.01861.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1750-3841.2010.01861.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23423566$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21535606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsieh, Chia-Chien</creatorcontrib><creatorcontrib>Hernández-Ledesma, Blanca</creatorcontrib><creatorcontrib>de Lumen, Ben O.</creatorcontrib><title>Soybean Peptide Lunasin Suppresses In Vitro and In Vivo 7,12-Dimethylbenz[a]anthracene-Induced Tumorigenesis</title><title>Journal of food science</title><addtitle>J Food Sci</addtitle><description>: Lunasin is a novel peptide identified in soybean and other seeds. This study evaluated the anti‐tumorigenic effects of lunasin on 7,12‐dimethylbenz(a)anthracene (DMBA) and 3‐methylcholanthrene‐treated (MCA) fibroblast NIH/3T3 cells. Lunasin significantly inhibited cell proliferation and cancerous foci formation in these 2 chemical carcinogens‐treated cells. An in vivo SENCAR mouse model induced with DMBA was used to study the mammary cancer preventive properties of dietary lunasin contained in soy protein. Tumor incidence was 67% and 50%, and the tumor generation was 1.88 ± 0.48 and 1.17 ± 0.17, respectively, for the mice fed control diet and experimental diet obtained after AIN‐93G supplementation with lunasin‐enriched soy protein concentrate (containing 0.23% lunasin). However, no effects were observed in mice fed AIN‐93G supplemented with soy protein concentrate (containing 0.15% lunasin). The data provided illustrate the anticancer potential of lunasin both in vitro and in vivo and supports the recommendation of soy protein as a dietary component that may aid in the prevention of mammary cancer.
Practical Application: Daily intake of lunasin‐enriched soy protein is introduced as a promising strategy to prevent chemical carcinogens‐induced mammary tumors.</description><subject>12-dimethylbenz(a)anthracene</subject><subject>3-methylcholanthrene</subject><subject>9,10-Dimethyl-1,2-benzanthracene - toxicity</subject><subject>Animal productions</subject><subject>Animal, plant, fungal and microbial proteins, edible seaweeds and food yeasts</subject><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biocompatibility</subject><subject>Biological and medical sciences</subject><subject>Biomedical materials</subject><subject>Cancer</subject><subject>cancer preventive properties</subject><subject>Carcinogens - toxicity</subject><subject>Cell Proliferation</subject><subject>Diet</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Female</subject><subject>Food industries</subject><subject>Food science</subject><subject>Functional foods & nutraceuticals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycine max - chemistry</subject><subject>In vivo testing</subject><subject>In vivo tests</subject><subject>lunasin</subject><subject>mammary cancer</subject><subject>Methylcholanthrene</subject><subject>Mice</subject><subject>Mice, Inbred SENCAR</subject><subject>Neoplasms, Experimental - chemically induced</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>NIH 3T3 Cells</subject><subject>Peptides</subject><subject>Peptides - analysis</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Soy products</subject><subject>soy protein</subject><subject>Soybean Proteins - chemistry</subject><subject>Soybean Proteins - pharmacology</subject><subject>Soybeans</subject><subject>Surgical implants</subject><subject>Terrestrial animal productions</subject><subject>Vertebrates</subject><issn>0022-1147</issn><issn>1750-3841</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2P0zAQhiMEYsvCX0AREuJCij_ij16QVl12KZQF1KUcELJsZ8K6pE6wE2j59SSkFIkTvoxn5plXo3mTJMVoivv3bDPFgqGMyhxPCeqrCEuOp7tbyeTYuJ1MECIkwzgXJ8m9GDdoyCm_m5wQzCjjiE-SalXvDWifvoOmdQWky87r6Hy66pomQIwQ04VP164Ndap9MSbf61Q8xSQ7d1tob_aVAf_zk_6sfXsTtAUP2cIXnYUive62dXBf-lJ08X5yp9RVhAeHeJp8uHhxPX-ZLd9eLuZny8wyTnBmESUlKrAsmRHSGktNLnBOTEGYAcSYFgiY4FwYw7VhxgKlSJaYcFnwckZPkyejbhPqbx3EVm1dtFBV2kPdRSXzWS4lQ6gnH_1Dbuou-H45JfFMEMER7SE5QjbUMQYoVRPcVoe9wkgNfqiNGs6uhrOrwQ_12w-160cfHvQ7s4XiOPjHgB54fAB0tLoqg_bWxb8czUkPDtzzkfvhKtj_9wLq1cX5avj2Atko4GILu6OADl8VF1Qw9fHqUr1Zo_n69dV7Jegv1xS04Q</recordid><startdate>201011</startdate><enddate>201011</enddate><creator>Hsieh, Chia-Chien</creator><creator>Hernández-Ledesma, Blanca</creator><creator>de Lumen, Ben O.</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope></search><sort><creationdate>201011</creationdate><title>Soybean Peptide Lunasin Suppresses In Vitro and In Vivo 7,12-Dimethylbenz[a]anthracene-Induced Tumorigenesis</title><author>Hsieh, Chia-Chien ; Hernández-Ledesma, Blanca ; de Lumen, Ben O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5621-c032f0d18f5b78cbc3b47142bd25be055a70e57667bb6ab5bce3308f1268d6f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>12-dimethylbenz(a)anthracene</topic><topic>3-methylcholanthrene</topic><topic>9,10-Dimethyl-1,2-benzanthracene - toxicity</topic><topic>Animal productions</topic><topic>Animal, plant, fungal and microbial proteins, edible seaweeds and food yeasts</topic><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biocompatibility</topic><topic>Biological and medical sciences</topic><topic>Biomedical materials</topic><topic>Cancer</topic><topic>cancer preventive properties</topic><topic>Carcinogens - toxicity</topic><topic>Cell Proliferation</topic><topic>Diet</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Female</topic><topic>Food industries</topic><topic>Food science</topic><topic>Functional foods & nutraceuticals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycine max - chemistry</topic><topic>In vivo testing</topic><topic>In vivo tests</topic><topic>lunasin</topic><topic>mammary cancer</topic><topic>Methylcholanthrene</topic><topic>Mice</topic><topic>Mice, Inbred SENCAR</topic><topic>Neoplasms, Experimental - chemically induced</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>NIH 3T3 Cells</topic><topic>Peptides</topic><topic>Peptides - analysis</topic><topic>Proteins</topic><topic>Rodents</topic><topic>Soy products</topic><topic>soy protein</topic><topic>Soybean Proteins - chemistry</topic><topic>Soybean Proteins - pharmacology</topic><topic>Soybeans</topic><topic>Surgical implants</topic><topic>Terrestrial animal productions</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsieh, Chia-Chien</creatorcontrib><creatorcontrib>Hernández-Ledesma, Blanca</creatorcontrib><creatorcontrib>de Lumen, Ben O.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Journal of food science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsieh, Chia-Chien</au><au>Hernández-Ledesma, Blanca</au><au>de Lumen, Ben O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soybean Peptide Lunasin Suppresses In Vitro and In Vivo 7,12-Dimethylbenz[a]anthracene-Induced Tumorigenesis</atitle><jtitle>Journal of food science</jtitle><addtitle>J Food Sci</addtitle><date>2010-11</date><risdate>2010</risdate><volume>75</volume><issue>9</issue><spage>H311</spage><epage>H316</epage><pages>H311-H316</pages><issn>0022-1147</issn><eissn>1750-3841</eissn><coden>JFDSAZ</coden><abstract>: Lunasin is a novel peptide identified in soybean and other seeds. This study evaluated the anti‐tumorigenic effects of lunasin on 7,12‐dimethylbenz(a)anthracene (DMBA) and 3‐methylcholanthrene‐treated (MCA) fibroblast NIH/3T3 cells. Lunasin significantly inhibited cell proliferation and cancerous foci formation in these 2 chemical carcinogens‐treated cells. An in vivo SENCAR mouse model induced with DMBA was used to study the mammary cancer preventive properties of dietary lunasin contained in soy protein. Tumor incidence was 67% and 50%, and the tumor generation was 1.88 ± 0.48 and 1.17 ± 0.17, respectively, for the mice fed control diet and experimental diet obtained after AIN‐93G supplementation with lunasin‐enriched soy protein concentrate (containing 0.23% lunasin). However, no effects were observed in mice fed AIN‐93G supplemented with soy protein concentrate (containing 0.15% lunasin). The data provided illustrate the anticancer potential of lunasin both in vitro and in vivo and supports the recommendation of soy protein as a dietary component that may aid in the prevention of mammary cancer.
Practical Application: Daily intake of lunasin‐enriched soy protein is introduced as a promising strategy to prevent chemical carcinogens‐induced mammary tumors.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>21535606</pmid><doi>10.1111/j.1750-3841.2010.01861.x</doi><tpages>6</tpages></addata></record> |
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| subjects | 12-dimethylbenz(a)anthracene 3-methylcholanthrene 9,10-Dimethyl-1,2-benzanthracene - toxicity Animal productions Animal, plant, fungal and microbial proteins, edible seaweeds and food yeasts Animals Antineoplastic Agents, Phytogenic - pharmacology Biocompatibility Biological and medical sciences Biomedical materials Cancer cancer preventive properties Carcinogens - toxicity Cell Proliferation Diet Dietary Proteins - administration & dosage Drug Screening Assays, Antitumor Female Food industries Food science Functional foods & nutraceuticals Fundamental and applied biological sciences. Psychology Glycine max - chemistry In vivo testing In vivo tests lunasin mammary cancer Methylcholanthrene Mice Mice, Inbred SENCAR Neoplasms, Experimental - chemically induced Neoplasms, Experimental - drug therapy NIH 3T3 Cells Peptides Peptides - analysis Proteins Rodents Soy products soy protein Soybean Proteins - chemistry Soybean Proteins - pharmacology Soybeans Surgical implants Terrestrial animal productions Vertebrates |
| title | Soybean Peptide Lunasin Suppresses In Vitro and In Vivo 7,12-Dimethylbenz[a]anthracene-Induced Tumorigenesis |
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