Comparision of biocompatibility and cytotoxicity of two new root canal sealers
The aim of this study was to investigate the remote organ toxicity and connective tissue reaction of two new root canal sealers (“GuttaFlow ®” and “EndoREZ ®”) and to compare them with zinc oxide eugenol sealer using biochemical and histopathological parameters. A total of 60 white albino Wistar rat...
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| Veröffentlicht in: | Acta histochemica 2010-11, Vol.112 (6), p.567-575 |
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| creator | Gencoglu, Nimet Sener, Göksel Omurtag, Gulden Z. Tozan, Ayfer Uslu, Bahar Arbak, Serap Helvacioglu, Dilek |
| description | The aim of this study was to investigate the remote organ toxicity and connective tissue reaction of two new root canal sealers (“GuttaFlow
®” and “EndoREZ
®”) and to compare them with zinc oxide eugenol sealer using biochemical and histopathological parameters. A total of 60 white albino Wistar rats were used in the study. 0.1
ml of GuttaFlow
®, EndoREZ
® or Kerr Pulp Canal Sealer
® were administered subcutaneously into the mid-dorsal thoracic region of rats (15 in each group). Control rats were given saline only. Rats were decapitated after 24
h, on day 7 and on day 30 of the experiment and tissue samples from lung, liver, kidney and skin were removed for the determination of malondialdehyde (MDA) and glutathione (GSH) levels. In parallel, tissues were also examined histologically. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and creatinine and blood urea nitrogen (BUN), concentrations (BUN) were measured to assess liver and kidney functions, respectively. Tumor necrosis factor (TNF) and lactate dehydrogenase (LDH) were also assayed in serum samples. No statistical differences were found among the control and EndoREZ
®, GuttaFlow
® and Kerr Pulp Canal sealers regarding tissue MDA, GSH levels or serum parameters (
p>0.05) at all time points examined. Both of the new root canal sealers showed good compatibility and acceptable tissue toxicity. |
| doi_str_mv | 10.1016/j.acthis.2009.06.005 |
| format | Article |
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®” and “EndoREZ
®”) and to compare them with zinc oxide eugenol sealer using biochemical and histopathological parameters. A total of 60 white albino Wistar rats were used in the study. 0.1
ml of GuttaFlow
®, EndoREZ
® or Kerr Pulp Canal Sealer
® were administered subcutaneously into the mid-dorsal thoracic region of rats (15 in each group). Control rats were given saline only. Rats were decapitated after 24
h, on day 7 and on day 30 of the experiment and tissue samples from lung, liver, kidney and skin were removed for the determination of malondialdehyde (MDA) and glutathione (GSH) levels. In parallel, tissues were also examined histologically. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and creatinine and blood urea nitrogen (BUN), concentrations (BUN) were measured to assess liver and kidney functions, respectively. Tumor necrosis factor (TNF) and lactate dehydrogenase (LDH) were also assayed in serum samples. No statistical differences were found among the control and EndoREZ
®, GuttaFlow
® and Kerr Pulp Canal sealers regarding tissue MDA, GSH levels or serum parameters (
p>0.05) at all time points examined. Both of the new root canal sealers showed good compatibility and acceptable tissue toxicity.</description><identifier>ISSN: 0065-1281</identifier><identifier>EISSN: 1618-0372</identifier><identifier>DOI: 10.1016/j.acthis.2009.06.005</identifier><identifier>PMID: 19775730</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Biocompatibility ; Canals ; Composite Resins - administration & dosage ; Composite Resins - adverse effects ; Composite Resins - toxicity ; Cytotoxicity ; Dimethylpolysiloxanes - administration & dosage ; Dimethylpolysiloxanes - adverse effects ; Dimethylpolysiloxanes - toxicity ; Drug Combinations ; EndoREZ ; Glutathione - analysis ; Gutta-Percha - adverse effects ; Gutta-Percha - toxicity ; GuttaFlow ; Injections, Subcutaneous ; Kerr pulp canal sealer ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; L-Lactate Dehydrogenase - blood ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Lung - drug effects ; Lung - pathology ; Macrophages - drug effects ; Macrophages - metabolism ; Macrophages - pathology ; Malondialdehyde - analysis ; Rats ; Rats, Wistar ; Root canal ; Root Canal Filling Materials - adverse effects ; Root Canal Filling Materials - toxicity ; Roots ; Samples ; Sealers ; Serums ; Skin - drug effects ; Skin - pathology ; Statistical methods ; Toxicity ; Tumor Necrosis Factor-alpha - analysis ; Zinc Oxide-Eugenol Cement - administration & dosage ; Zinc Oxide-Eugenol Cement - adverse effects ; Zinc Oxide-Eugenol Cement - toxicity</subject><ispartof>Acta histochemica, 2010-11, Vol.112 (6), p.567-575</ispartof><rights>2009 Elsevier GmbH</rights><rights>Copyright © 2009 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-b798cb751bb7787169d2cf80e80984a2c30b8ba0008fcda281a49ba4c54893853</citedby><cites>FETCH-LOGICAL-c393t-b798cb751bb7787169d2cf80e80984a2c30b8ba0008fcda281a49ba4c54893853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0065128109000695$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19775730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gencoglu, Nimet</creatorcontrib><creatorcontrib>Sener, Göksel</creatorcontrib><creatorcontrib>Omurtag, Gulden Z.</creatorcontrib><creatorcontrib>Tozan, Ayfer</creatorcontrib><creatorcontrib>Uslu, Bahar</creatorcontrib><creatorcontrib>Arbak, Serap</creatorcontrib><creatorcontrib>Helvacioglu, Dilek</creatorcontrib><title>Comparision of biocompatibility and cytotoxicity of two new root canal sealers</title><title>Acta histochemica</title><addtitle>Acta Histochem</addtitle><description>The aim of this study was to investigate the remote organ toxicity and connective tissue reaction of two new root canal sealers (“GuttaFlow
®” and “EndoREZ
®”) and to compare them with zinc oxide eugenol sealer using biochemical and histopathological parameters. A total of 60 white albino Wistar rats were used in the study. 0.1
ml of GuttaFlow
®, EndoREZ
® or Kerr Pulp Canal Sealer
® were administered subcutaneously into the mid-dorsal thoracic region of rats (15 in each group). Control rats were given saline only. Rats were decapitated after 24
h, on day 7 and on day 30 of the experiment and tissue samples from lung, liver, kidney and skin were removed for the determination of malondialdehyde (MDA) and glutathione (GSH) levels. In parallel, tissues were also examined histologically. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and creatinine and blood urea nitrogen (BUN), concentrations (BUN) were measured to assess liver and kidney functions, respectively. Tumor necrosis factor (TNF) and lactate dehydrogenase (LDH) were also assayed in serum samples. No statistical differences were found among the control and EndoREZ
®, GuttaFlow
® and Kerr Pulp Canal sealers regarding tissue MDA, GSH levels or serum parameters (
p>0.05) at all time points examined. Both of the new root canal sealers showed good compatibility and acceptable tissue toxicity.</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Canals</subject><subject>Composite Resins - administration & dosage</subject><subject>Composite Resins - adverse effects</subject><subject>Composite Resins - toxicity</subject><subject>Cytotoxicity</subject><subject>Dimethylpolysiloxanes - administration & dosage</subject><subject>Dimethylpolysiloxanes - adverse effects</subject><subject>Dimethylpolysiloxanes - toxicity</subject><subject>Drug Combinations</subject><subject>EndoREZ</subject><subject>Glutathione - analysis</subject><subject>Gutta-Percha - adverse effects</subject><subject>Gutta-Percha - toxicity</subject><subject>GuttaFlow</subject><subject>Injections, Subcutaneous</subject><subject>Kerr pulp canal sealer</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - pathology</subject><subject>Malondialdehyde - analysis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Root canal</subject><subject>Root Canal Filling Materials - adverse effects</subject><subject>Root Canal Filling Materials - toxicity</subject><subject>Roots</subject><subject>Samples</subject><subject>Sealers</subject><subject>Serums</subject><subject>Skin - drug effects</subject><subject>Skin - pathology</subject><subject>Statistical methods</subject><subject>Toxicity</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Zinc Oxide-Eugenol Cement - administration & dosage</subject><subject>Zinc Oxide-Eugenol Cement - adverse effects</subject><subject>Zinc Oxide-Eugenol Cement - toxicity</subject><issn>0065-1281</issn><issn>1618-0372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMozjj6BiLduWo9adom2QgyeINBN7oOSZpihk4zJhl13t6UDrhzdeDw_efyIXSJocCAm5t1IXX8sKEoAXgBTQFQH6E5bjDLgdDyGM0BmjrHJcMzdBbCGhIIpDxFM8wprSmBOXpZus1WehusGzLXZco6PXaiVba3cZ_Joc30PrrofqweGwmK3y4bzHfmnYuZloPss2Bkb3w4Ryed7IO5ONQFen-4f1s-5avXx-fl3SrXhJOYK8qZVrTGSlHKKG54W-qOgWHAWSVLTUAxJdPBrNOtTB_IiitZ6bpinLCaLND1NHfr3efOhCg2NmjT93IwbhcEq3jFaINpIquJ1N6F4E0ntt5upN8LDGIUKdZiEilGkQIakUSm2NVhwU5tTPsXOphLwO0EmPTmlzVeBG3NoE1rvdFRtM7-v-EXJOeGnQ</recordid><startdate>201011</startdate><enddate>201011</enddate><creator>Gencoglu, Nimet</creator><creator>Sener, Göksel</creator><creator>Omurtag, Gulden Z.</creator><creator>Tozan, Ayfer</creator><creator>Uslu, Bahar</creator><creator>Arbak, Serap</creator><creator>Helvacioglu, Dilek</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>201011</creationdate><title>Comparision of biocompatibility and cytotoxicity of two new root canal sealers</title><author>Gencoglu, Nimet ; Sener, Göksel ; Omurtag, Gulden Z. ; Tozan, Ayfer ; Uslu, Bahar ; Arbak, Serap ; Helvacioglu, Dilek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-b798cb751bb7787169d2cf80e80984a2c30b8ba0008fcda281a49ba4c54893853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biocompatibility</topic><topic>Canals</topic><topic>Composite Resins - administration & dosage</topic><topic>Composite Resins - adverse effects</topic><topic>Composite Resins - toxicity</topic><topic>Cytotoxicity</topic><topic>Dimethylpolysiloxanes - administration & dosage</topic><topic>Dimethylpolysiloxanes - adverse effects</topic><topic>Dimethylpolysiloxanes - toxicity</topic><topic>Drug Combinations</topic><topic>EndoREZ</topic><topic>Glutathione - analysis</topic><topic>Gutta-Percha - adverse effects</topic><topic>Gutta-Percha - toxicity</topic><topic>GuttaFlow</topic><topic>Injections, Subcutaneous</topic><topic>Kerr pulp canal sealer</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - pathology</topic><topic>Malondialdehyde - analysis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Root canal</topic><topic>Root Canal Filling Materials - adverse effects</topic><topic>Root Canal Filling Materials - toxicity</topic><topic>Roots</topic><topic>Samples</topic><topic>Sealers</topic><topic>Serums</topic><topic>Skin - drug effects</topic><topic>Skin - pathology</topic><topic>Statistical methods</topic><topic>Toxicity</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Zinc Oxide-Eugenol Cement - administration & dosage</topic><topic>Zinc Oxide-Eugenol Cement - adverse effects</topic><topic>Zinc Oxide-Eugenol Cement - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gencoglu, Nimet</creatorcontrib><creatorcontrib>Sener, Göksel</creatorcontrib><creatorcontrib>Omurtag, Gulden Z.</creatorcontrib><creatorcontrib>Tozan, Ayfer</creatorcontrib><creatorcontrib>Uslu, Bahar</creatorcontrib><creatorcontrib>Arbak, Serap</creatorcontrib><creatorcontrib>Helvacioglu, Dilek</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Acta histochemica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gencoglu, Nimet</au><au>Sener, Göksel</au><au>Omurtag, Gulden Z.</au><au>Tozan, Ayfer</au><au>Uslu, Bahar</au><au>Arbak, Serap</au><au>Helvacioglu, Dilek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparision of biocompatibility and cytotoxicity of two new root canal sealers</atitle><jtitle>Acta histochemica</jtitle><addtitle>Acta Histochem</addtitle><date>2010-11</date><risdate>2010</risdate><volume>112</volume><issue>6</issue><spage>567</spage><epage>575</epage><pages>567-575</pages><issn>0065-1281</issn><eissn>1618-0372</eissn><abstract>The aim of this study was to investigate the remote organ toxicity and connective tissue reaction of two new root canal sealers (“GuttaFlow
®” and “EndoREZ
®”) and to compare them with zinc oxide eugenol sealer using biochemical and histopathological parameters. A total of 60 white albino Wistar rats were used in the study. 0.1
ml of GuttaFlow
®, EndoREZ
® or Kerr Pulp Canal Sealer
® were administered subcutaneously into the mid-dorsal thoracic region of rats (15 in each group). Control rats were given saline only. Rats were decapitated after 24
h, on day 7 and on day 30 of the experiment and tissue samples from lung, liver, kidney and skin were removed for the determination of malondialdehyde (MDA) and glutathione (GSH) levels. In parallel, tissues were also examined histologically. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and creatinine and blood urea nitrogen (BUN), concentrations (BUN) were measured to assess liver and kidney functions, respectively. Tumor necrosis factor (TNF) and lactate dehydrogenase (LDH) were also assayed in serum samples. No statistical differences were found among the control and EndoREZ
®, GuttaFlow
® and Kerr Pulp Canal sealers regarding tissue MDA, GSH levels or serum parameters (
p>0.05) at all time points examined. Both of the new root canal sealers showed good compatibility and acceptable tissue toxicity.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>19775730</pmid><doi>10.1016/j.acthis.2009.06.005</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0065-1281 |
| ispartof | Acta histochemica, 2010-11, Vol.112 (6), p.567-575 |
| issn | 0065-1281 1618-0372 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_849487617 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biocompatibility Canals Composite Resins - administration & dosage Composite Resins - adverse effects Composite Resins - toxicity Cytotoxicity Dimethylpolysiloxanes - administration & dosage Dimethylpolysiloxanes - adverse effects Dimethylpolysiloxanes - toxicity Drug Combinations EndoREZ Glutathione - analysis Gutta-Percha - adverse effects Gutta-Percha - toxicity GuttaFlow Injections, Subcutaneous Kerr pulp canal sealer Kidney - drug effects Kidney - metabolism Kidney - pathology L-Lactate Dehydrogenase - blood Liver - drug effects Liver - metabolism Liver - pathology Lung - drug effects Lung - pathology Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Malondialdehyde - analysis Rats Rats, Wistar Root canal Root Canal Filling Materials - adverse effects Root Canal Filling Materials - toxicity Roots Samples Sealers Serums Skin - drug effects Skin - pathology Statistical methods Toxicity Tumor Necrosis Factor-alpha - analysis Zinc Oxide-Eugenol Cement - administration & dosage Zinc Oxide-Eugenol Cement - adverse effects Zinc Oxide-Eugenol Cement - toxicity |
| title | Comparision of biocompatibility and cytotoxicity of two new root canal sealers |
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