Lipid-like Diblock Copolymer as an Additive for Improving the Blood Compatibility of Poly(lactide-co-glycolide)
To optimize the blood biocompatibility of poly(lactide-coglycolide) (PLGA), lipid-like diblock copolymer poly(DL-lactide)-block-poly(2-methacryloyloxyethyl phosphorylcholine) (PLA-b-PMPC) was employed as a surface-modifying additive. The blends of PLGA and PLA-b-PMPC coated poly(ethylene terephthala...
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| Veröffentlicht in: | Journal of bioactive and compatible polymers 2010-11, Vol.25 (6), p.654-668 |
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| container_title | Journal of bioactive and compatible polymers |
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| creator | Hu, Xiaofen Liu, Gongyan Ji, Jian Fan, Dezeng Yan, Xinhao |
| description | To optimize the blood biocompatibility of poly(lactide-coglycolide) (PLGA), lipid-like diblock copolymer poly(DL-lactide)-block-poly(2-methacryloyloxyethyl phosphorylcholine) (PLA-b-PMPC) was employed as a surface-modifying additive. The blends of PLGA and PLA-b-PMPC coated poly(ethylene terephthalate) membranes were prepared by dip-coating. ATR-FTIR spectroscopy showed the incorporation of phosphorylcoline groups in the blends and contact angle results indicated that the hydrophilicity of the blends improved with increasing PLA-b-PMPC content. The plasma recalcification time of polymer coating was prolonged and the amount of adherent platelets on coating surface was decreased by introducing PLA-b-PMPC. The adhesion of polymer coating on the gold electrode of quartz crystal microbalance was monitored and PLGA containing PLA-b-PMPC additives showed excellent polymer—metal adhesion. These results show that the blends of PLGA and lipid-like PLA-b-PMPC could be used as high performance biodegradable polymer coatings for blood contact medical devices. |
| doi_str_mv | 10.1177/0883911510384836 |
| format | Article |
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The blends of PLGA and PLA-b-PMPC coated poly(ethylene terephthalate) membranes were prepared by dip-coating. ATR-FTIR spectroscopy showed the incorporation of phosphorylcoline groups in the blends and contact angle results indicated that the hydrophilicity of the blends improved with increasing PLA-b-PMPC content. The plasma recalcification time of polymer coating was prolonged and the amount of adherent platelets on coating surface was decreased by introducing PLA-b-PMPC. The adhesion of polymer coating on the gold electrode of quartz crystal microbalance was monitored and PLGA containing PLA-b-PMPC additives showed excellent polymer—metal adhesion. These results show that the blends of PLGA and lipid-like PLA-b-PMPC could be used as high performance biodegradable polymer coatings for blood contact medical devices.</description><identifier>ISSN: 0883-9115</identifier><identifier>EISSN: 1530-8030</identifier><identifier>DOI: 10.1177/0883911510384836</identifier><identifier>CODEN: JBCPEV</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Applied sciences ; Biological and medical sciences ; Exact sciences and technology ; Exchange resins and membranes ; Forms of application and semi-finished materials ; Medical sciences ; Organic polymers ; Physicochemistry of polymers ; Polymer industry, paints, wood ; Polymers with particular properties ; Preparation, kinetics, thermodynamics, mechanism and catalysts ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology of polymers ; Technology. Biomaterials. 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The blends of PLGA and PLA-b-PMPC coated poly(ethylene terephthalate) membranes were prepared by dip-coating. ATR-FTIR spectroscopy showed the incorporation of phosphorylcoline groups in the blends and contact angle results indicated that the hydrophilicity of the blends improved with increasing PLA-b-PMPC content. The plasma recalcification time of polymer coating was prolonged and the amount of adherent platelets on coating surface was decreased by introducing PLA-b-PMPC. The adhesion of polymer coating on the gold electrode of quartz crystal microbalance was monitored and PLGA containing PLA-b-PMPC additives showed excellent polymer—metal adhesion. These results show that the blends of PLGA and lipid-like PLA-b-PMPC could be used as high performance biodegradable polymer coatings for blood contact medical devices.</description><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Exact sciences and technology</subject><subject>Exchange resins and membranes</subject><subject>Forms of application and semi-finished materials</subject><subject>Medical sciences</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>Polymer industry, paints, wood</subject><subject>Polymers with particular properties</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology of polymers</subject><subject>Technology. Biomaterials. 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Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology of polymers</topic><topic>Technology. Biomaterials. Equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Xiaofen</creatorcontrib><creatorcontrib>Liu, Gongyan</creatorcontrib><creatorcontrib>Ji, Jian</creatorcontrib><creatorcontrib>Fan, Dezeng</creatorcontrib><creatorcontrib>Yan, Xinhao</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of bioactive and compatible polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Xiaofen</au><au>Liu, Gongyan</au><au>Ji, Jian</au><au>Fan, Dezeng</au><au>Yan, Xinhao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid-like Diblock Copolymer as an Additive for Improving the Blood Compatibility of Poly(lactide-co-glycolide)</atitle><jtitle>Journal of bioactive and compatible polymers</jtitle><date>2010-11-01</date><risdate>2010</risdate><volume>25</volume><issue>6</issue><spage>654</spage><epage>668</epage><pages>654-668</pages><issn>0883-9115</issn><eissn>1530-8030</eissn><coden>JBCPEV</coden><abstract>To optimize the blood biocompatibility of poly(lactide-coglycolide) (PLGA), lipid-like diblock copolymer poly(DL-lactide)-block-poly(2-methacryloyloxyethyl phosphorylcholine) (PLA-b-PMPC) was employed as a surface-modifying additive. The blends of PLGA and PLA-b-PMPC coated poly(ethylene terephthalate) membranes were prepared by dip-coating. ATR-FTIR spectroscopy showed the incorporation of phosphorylcoline groups in the blends and contact angle results indicated that the hydrophilicity of the blends improved with increasing PLA-b-PMPC content. The plasma recalcification time of polymer coating was prolonged and the amount of adherent platelets on coating surface was decreased by introducing PLA-b-PMPC. The adhesion of polymer coating on the gold electrode of quartz crystal microbalance was monitored and PLGA containing PLA-b-PMPC additives showed excellent polymer—metal adhesion. These results show that the blends of PLGA and lipid-like PLA-b-PMPC could be used as high performance biodegradable polymer coatings for blood contact medical devices.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><doi>10.1177/0883911510384836</doi><tpages>15</tpages></addata></record> |
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| subjects | Applied sciences Biological and medical sciences Exact sciences and technology Exchange resins and membranes Forms of application and semi-finished materials Medical sciences Organic polymers Physicochemistry of polymers Polymer industry, paints, wood Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology of polymers Technology. Biomaterials. Equipments |
| title | Lipid-like Diblock Copolymer as an Additive for Improving the Blood Compatibility of Poly(lactide-co-glycolide) |
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